tag:blogger.com,1999:blog-1518112385956949782024-03-18T17:34:25.853-04:00Deans' stroke musings<big><b>Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only <big>27,536</big> posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.<b><big>DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER. </big></b></b></big>
oc1deanhttp://www.blogger.com/profile/02302555382262295577noreply@blogger.comBlogger27537125tag:blogger.com,1999:blog-151811238595694978.post-88761686636204749912024-03-18T17:33:00.002-04:002024-03-18T17:33:50.356-04:00A longevity expert shares 3 tips for a nutritious anti-aging breakfast<h3 style="text-align: left;">How long before your competent? doctor gets the dietician to incorporate this into your hospital diet? <span> NEVER? Then you don't have a functioning stroke doctor. I don't know what you have but it's not a stroke doctor you want to have.</span> <br /></h3><h3><u><a href="https://www.msn.com/en-us/health/nutrition/a-longevity-expert-shares-3-tips-for-a-nutritious-anti-aging-breakfast/ar-AA1hi5Tg?ocid=msedgdhp&pc=SMTS&cvid=5ebc3662813b430a928ed700a113a8ea&ei=18" target="_blank">A longevity expert shares 3 tips for a nutritious anti-aging breakfast</a></u></h3><div style="text-align: left;"><div class="article-list-slot" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;"><ul class="summary-list" style="padding-inline-start: 20px;"><li data-t="{"n":"blueLinks"}" style="font-size: 18px; line-height: 28px; margin: 10px 0px;"><strong>Longevity expert Valter Longo developed the longevity diet, which is essentially "vegan plus fish."</strong></li><li data-t="{"n":"blueLinks"}" style="font-size: 18px; line-height: 28px; margin: 10px 0px;">Here, he offers tips on putting together a longevity-boosting breakfast.</li><li data-t="{"n":"blueLinks"}" style="font-size: 18px; line-height: 28px; margin: 10px 0px;">He recommends including lots of food groups and getting creative with ingredients.</li></ul></div><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">An expert in longevity told Insider his three tips for making healthy, enjoyable<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.insider.com/dash-diet-breakfast-ideas-to-help-you-get-healthier-2020-1" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">breakfasts</a><span> </span>with anti-aging benefits.</p><p class="continue-read-break" data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; opacity: 1; orphans: 2; position: static; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">Valter Longo is a professor in gerontology and director of the USC Longevity Institute who developed the longevity diet — a diet that he says is essentially "<a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.insider.com/guides/health/diet-nutrition/vegan-diet" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">vegan</a><span> </span>plus fish." The longevity diet is rich in legumes, whole grains, nuts, and seeds, and relatively low in protein. The diet's principles are based on<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.verywellhealth.com/the-longevity-diet-plan-overview-2223476" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">Longo's own research</a><span> </span>on populations around the world that live especially long lives.</p><div class="article-slideshow-slot slot-placeholder" data-doc-id="AA1hhZ7o" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; orphans: 2; padding-bottom: 36px; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;"><div class="article-slideshow-slot"><div class="slideshow embedded aligned" style="color: var(--neutral-foreground-rest); 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display: flex; flex-direction: column; gap: 4px; padding: 0px;"><span class="title embedded" style="color: var(--neutral-foreground-rest); font-size: 14px; font-weight: 600; line-height: 16px;">A doctor who wrote a book on the Mediterranean diet shares his 4 favorite snacks</span><span class="copyright" style="color: var(--neutral-foreground-hint); font-size: 12px; font-weight: 400; line-height: 16px;">©Dr. Simon Poole</span></div></div><div class="collapsed" style="mask-image: linear-gradient(rgb(0, 0, 0) 50%, transparent); max-height: 120px; overflow: hidden;"><span class="body embedded" style="color: var(--neutral-foreground-rest); font-size: 14px; font-weight: 400; line-height: 16px;"><ul class="summary-list"><li>The Mediterranean diet is widely considered the healthiest way to eat.</li><li>Dr. Simon Poole, a dietary expert, shared his favorite Mediterranean snack ideas with Insider.</li><li>He said to try simple foods such as olives, skin-on nuts, and chocolate (but make sure it's dark).</li></ul><p>The<span> </span><a href="https://www.insider.com/mediterranean-diet-ranked-as-best-diet-of-year-6th-time-2023-01" rel="" style="color: var(--accent-foreground-rest); text-decoration: none;">Mediterranean diet</a><span> </span>is widely considered the healthiest way to eat.</p><p>It prioritizes eating vegetables, legumes, seafood, and<span> </span><a href="https://www.insider.com/guides/health/diet-nutrition/olive-oil-benefits" style="color: var(--accent-foreground-rest); text-decoration: none;">olive oil</a><span> </span>with minimal amounts of<span> </span><a href="https://www.insider.com/eating-ultra-processed-foods-ovarian-brain-cancer-risk-2022-2" style="color: var(--accent-foreground-rest); text-decoration: none;">processed and fried foods</a>, red meat, refined grains, sugar, and saturated fat.</p><p>Dr. Simon Poole, a dietary expert based in the UK, told Insider that there was a "very<span> </span><a href="https://www.insider.com/guides/health/diet-nutrition/mediterranean-diet" rel="" style="color: var(--accent-foreground-rest); text-decoration: none;">considerable amount of really good, high quality scientific research</a><span> </span>to show that it reduces the risks of really so many chronic diseases, from<span> </span><a href="https://www.insider.com/mediterranean-diet-lower-heart-disease-risk-women-study-2023-3#:~:text=It%20encourages%20minimal%20consumption%20of,fiber%2C%20and%20limits%20refined%20carbs." style="color: var(--accent-foreground-rest); text-decoration: none;">heart disease</a><span> </span>and stroke through to many cancers and even Alzheimer's disease."</p><p>It's also associated with<span> </span><a href="https://www.insider.com/longevity-researcher-harvard-david-sinclair-53-biological-age-decade-younger-2023-3" rel="" style="color: var(--accent-foreground-rest); text-decoration: none;">longevity</a>, better mental health, and maintaining a healthy weight, so it can improve quality of life in many areas as well, Poole said.</p><p>He shared four of his favorite Mediterranean diet snack ideas with Insider, following on from his favorite<span> </span><a href="https://www.insider.com/mediterranean-diet-breakfast-recipes-2023-6" style="color: var(--accent-foreground-rest); text-decoration: none;">breakfasts</a>,<span> </span><a href="https://www.insider.com/mediterranean-diet-lunch-recipes-2023-6" style="color: var(--accent-foreground-rest); text-decoration: none;">lunches</a>, and<span> </span><a href="https://www.insider.com/mediterranean-diet-dinner-recipes-2023-7" style="color: var(--accent-foreground-rest); text-decoration: none;">dinners</a>.</p></span></div><button class="see-more-btn" hidden="true" name="see-more" style="align-items: center; background: transparent; border: none; color: #3091dc; cursor: pointer; display: flex; font-size: 14px; justify-content: flex-start; margin-top: 0px; padding: 0px; text-align: center;" type="button"><span>See more</span><span><svg height="16" viewbox="0 0 16 16" width="16" xmlns="http://www.w3.org/2000/svg"><path d="M4.96 5a1 1 0 00-.82 1.57l2.63 3.79c.6.85 1.86.85 2.46 0l2.63-3.79A1 1 0 0011.04 5H4.96z"></path></svg></span></button></div></div></div><p class="" data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">It also includes periods of fasting, and encourages as much walking as possible to mimic the habits of<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.insider.com/ways-exercise-can-help-live-longer-longevity-2023-9" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">centenarians living traditionally</a><span> </span>active lifestyles.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">Here are Longo's tips for making nutritious breakfasts to help<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.insider.com/quick-life-hacks-increase-longevity-2023-8" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">improve longevity</a>.</p><h2 class="article-sub-heading" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Eb Garamond"; font-size: 30px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 500; letter-spacing: normal; line-height: 38px; margin-bottom: 24px; margin-top: 48px; orphans: 2; position: relative; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">Eat a breakfast that contains multiple food groups</h2><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">First of all, "you have to have breakfast," Longo said.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">A healthy breakfast on the longevity diet might contain<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.insider.com/grains-with-the-most-nutrition-2017-4" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">whole grains</a>, nuts, and fruit.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">Longo himself likes to have friselle, a whole-grain bread from Italy, with a nut spread containing almond and cocoa, as well as an apple.</p><div class="intra-article-module" data-t="{"n":"intraArticle","t":13}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; orphans: 2; position: relative; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; width: 682px; word-spacing: 0px; z-index: 97;"><div class="articlePageIntraArticleFullWidth left-image-intra-ad"><div class="intra-article-relatedcontent" style="min-height: 475px;"><div class="video-clear-div" style="clear: both; display: block;"></div><p class="related-video-divider-top video-title" data-test-id="video-embed-title" style="-webkit-box-orient: vertical; -webkit-line-clamp: 2; border-top: 1px solid rgba(0, 0, 0, 0.09); display: -webkit-box; margin-block-end: 8px; overflow: hidden; padding-top: 8px;"><img src="https://assets.msn.com/staticsb/statics/latest/icons-wc/icons/VideoBlue.svg" style="background-image: linear-gradient(white, white); background-position: center center; background-repeat: no-repeat; background-size: 8px 8px; margin-inline-end: 8px;" /><span class="related-video-title-bold" style="font-weight: 600;">Related video</span>:<span> </span>Top 5 Foods That Seniors Should Incorporate Into Their Diet<span> </span>(Saving Advice)</p><div class="video-wrapper " style="height: 383.625px; position: relative; width: 682px;"><div class=" videocard1PP video-embed-common related-video-divider-bottom videocardRelatedVideo" style="aspect-ratio: 16 / 9; box-sizing: content-box !important; height: 383.625px; margin-bottom: 32px; position: relative; width: 682px;"><div class=" content-video-container large-title " data-t="{"n":"ContentVideoPlayer","t":61,"c.i":"BB1jmMt3","c.l":false,"c.t":61,"c.v":"foodanddrink","c.c":"newstrends","c.b":"Saving Advice","c.bi":"AAX9Ee3","ext":{"videoId":"BB1jmMt3","videoCs":"AAX9Ee3","eventType":31,"timeElasped":8,"videoFormatCode":1006,"title":"Top 5 Foods That Seniors Should Incorporate Into Their Diet","videoDuration":72,"fr":"en-us_health","playType":"embed","playerTech":"MSNPlayer","size":"682x384","isContinuous":false,"isMuted":true,"playDuration":8,"inline":true,"videoPlayerType":"BingMM","perf":{}},"m.c":false,"c.hl":"Top 5 Foods That Seniors Should Incorporate Into Their Diet"}" style="aspect-ratio: 16 / 9; 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box-sizing: inherit; height: 383.625px; left: 0px; position: absolute; top: 0px; width: 682px;" tabindex="-1"></video><div aria-atomic="true" aria-live="off" class="vjs-text-track-display" style="box-sizing: inherit; inset: 0px 0px 5.6em; margin-bottom: 1.2em; pointer-events: none; position: absolute;"><div style="box-sizing: inherit; inset: 0px; margin: 10.2273px; position: absolute;"><div class="vjs-text-track-cue vjs-text-track-cue-en-us" lang="en-us" style="background-color: rgba(0, 0, 0, 0); box-sizing: inherit; direction: ltr; font: 17.06px sans-serif; height: 19.6364px; inset: 321.534px 0px 0px; position: absolute; text-align: center; unicode-bidi: plaintext; white-space: pre-line; width: 661.545px; writing-mode: horizontal-tb;"><div style="background-color: black; box-sizing: inherit; color: white; display: inline; font-family: sans-serif; inset: 0px; position: relative; unicode-bidi: plaintext; writing-mode: horizontal-tb;">leafy greens, spinach, kale, Swiss Chard and other leafy greens</div></div></div></div><div class="vjs-control-bar endSlate-controlbar" dir="ltr" style="background: linear-gradient(rgba(0, 0, 0, 0) 0%, rgba(0, 0, 0, 0.8) 75.47%, rgba(0, 0, 0, 0.8) 100%); 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cursor: pointer; display: flex; flex: 0 0 100%; height: 1.5em; margin: 0px; min-width: 4em; padding: 0px 8px; position: relative; text-align: center; top: 10px; touch-action: none; width: 4em; z-index: 10;"><div aria-label="Progress Bar" aria-valuemax="100" aria-valuemin="0" aria-valuenow="11.31" aria-valuetext="0:08 of 1:12" class="vjs-progress-holder vjs-slider vjs-slider-horizontal" role="slider" style="background-color: rgba(255, 255, 255, 0.4); box-sizing: inherit; cursor: pointer; flex: 1 1 auto; height: 0.5em; margin: 0px 10px; padding: 0px; position: relative; transition: all 0.2s ease 0s; user-select: none;" tabindex="0"><div class="vjs-load-progress" style="background: rgba(255, 255, 255, 0.6); border-radius: 3px; box-sizing: inherit; display: block; height: 5px; margin: 0px; padding: 0px; position: absolute; width: 269.182px;"><span class="vjs-control-text" style="border: 0px; box-sizing: inherit; clip: rect(0px, 0px, 0px, 0px); height: 1px; overflow: hidden; padding: 0px; position: absolute; 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appearance: none; background: 0px 0px; border: none; box-sizing: inherit; color: inherit; cursor: pointer; display: inline-block; flex: 0 0 auto; font-size: inherit; height: calc(100% - 1.5em - 10px); line-height: inherit; margin: 0px; padding: 0px; position: relative; text-align: center; text-decoration: none; text-transform: none; top: 5px; transition: none 0s ease 0s; user-select: none; width: 4em;" title="Seek Back" type="button"><img src="https://assets.msn.com/staticsb/statics/latest/views/icons/video/videoSeekBack.svg" style="box-sizing: inherit;" /></button><button aria-disabled="false" class="vjs-control vjs-button vjs-seek-forward-button" data-t="{"n":"SeekForward","t":61,"a":"click","b":59,"ext":{"videoCs":"BB1jmMt3","videoFormatCode":1006,"title":"Top 5 Foods That Seniors Should Incorporate Into Their Diet","videoDuration":72,"playerInstanceId":"","playType":"pb","playerTech":"HTML5","pluginVersion":"HTML5","size":"0x0","videoPlayerType":"mp4:progressive","playerType":"HTML5","videoUrl":"https://prod-streaming-video-msn-com.akamaized.net/4b00739e-65f3-4662-b04b-9dce380101bd/59415ea8-2263-4e6d-8a78-bd4b91db2264.mp4"}}" style="-webkit-tap-highlight-color: transparent; appearance: none; background: 0px 0px; border: none; box-sizing: inherit; color: inherit; cursor: pointer; display: inline-block; flex: 0 0 auto; font-size: inherit; height: calc(100% - 1.5em - 10px); line-height: inherit; margin: 0px; padding: 0px; position: relative; text-align: center; text-decoration: none; text-transform: none; top: 5px; transition: none 0s ease 0s; user-select: none; width: 4em;" title="Seek Forward" type="button"><img src="https://assets.msn.com/staticsb/statics/latest/views/icons/video/videoSeekForward.svg" style="box-sizing: inherit;" /></button><div class="vjs-current-time vjs-time-control vjs-control" style="-webkit-tap-highlight-color: transparent; box-sizing: inherit; display: block; flex: 0 0 auto; font-size: 1.5em; height: calc(100% - 1.5em - 10px); line-height: 3em; margin: 0px; min-width: 2em; padding: 0px 0.4em; position: relative; text-align: center; top: 5px; width: auto;"><span class="vjs-control-text" role="presentation" style="border: 0px; box-sizing: inherit; 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background: rgba(0, 0, 0, 0.6); border-radius: 4px; bottom: 0px; display: flex; flex-direction: row; font-size: 12px; font-weight: 600; height: 20px; line-height: 16px; margin: 12px; padding: 2px 8px 2px 4px; position: absolute; width: 54px;"><span style="height: 12px; margin: 4px 6px; width: 12px;"><svg fill="none" height="12" viewbox="0 0 12 12" width="12" xmlns="http://www.w3.org/2000/svg"><path d="M6 0C9.31371 0 12 2.68629 12 6C12 9.31371 9.31371 12 6 12C2.68629 12 0 9.31371 0 6C0 2.68629 2.68629 0 6 0ZM6 1C3.23858 1 1 3.23858 1 6C1 8.76142 3.23858 11 6 11C8.76142 11 11 8.76142 11 6C11 3.23858 8.76142 1 6 1ZM5.50153 3C5.74699 3 5.95114 3.17688 5.99347 3.41012L6.00153 3.5V6H7.5C7.77614 6 8 6.22386 8 6.5C8 6.74546 7.82312 6.94961 7.58988 6.99194L7.5 7H5.50153C5.25607 7 5.05192 6.82312 5.00958 6.58988L5.00153 6.5V3.5C5.00153 3.22386 5.22538 3 5.50153 3Z" fill="white"></path></svg></span>0:56</div></div></div></a></li></ul></div></div></div><div class="video-clear-div" style="clear: both; display: block;"></div></div></div></div><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">Almond butter is one of the<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.insider.com/which-type-of-nut-butter-is-best-2019-2" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">healthiest nut butters</a><span> </span>as long as it doesn't contain added sugar, dietitian Allison Childress previously told Insider, because it contains vitamins and minerals such as vitamin E, magnesium, and calcium.</p><h2 class="article-sub-heading" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Eb Garamond"; font-size: 30px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 500; letter-spacing: normal; line-height: 38px; margin-bottom: 24px; margin-top: 48px; orphans: 2; position: relative; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">Make sure you eat things you enjoy</h2><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">You shouldn't put pressure on yourself to eat things that you won't enjoy just because they are good for you; Longo said that whatever you eat should "be a version of what you like based on the general rules" of the longevity diet, not necessarily what he would eat.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">For example, Longo's fig, nut, and<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.valterlongo.com/recipes-of-longevity/#tab-id-36" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">cornmeal "cookies,"</a><span> </span>or<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.insider.com/tiktok-trend-baked-oats-helped-me-lose-fat-gain-muscle-2021-3" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">baked oats</a><span> </span>with fruit and nuts, could be good options.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">Dietitian Danielle Smith previously told Insider that there's no point trying to force yourself to eat something if it doesn't make you feel good or you just don't like it, as this will make it harder to maintain the switch to a healthy diet over time. It's much better to "focus on other<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.insider.com/dash-diet-mistakes-to-avoid-2023-8" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">nutrient dense foods</a>" that you do like, she said.</p><h2 class="article-sub-heading" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Eb Garamond"; font-size: 30px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 500; letter-spacing: normal; line-height: 38px; margin-bottom: 24px; margin-top: 48px; orphans: 2; position: relative; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">Don't be afraid of making changes to get more nutrients in your breakfast</h2><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">In the same vein, Longo makes changes to his breakfasts to get more nutrients in without sacrificing taste.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">He makes his morning cup of tea with two tea bags: one green tea bag and one black. This is because "the green doesn't taste as good as the black," he said, but he can still reap the nutritional benefits of the green tea.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;"><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.insider.com/guides/health/diet-nutrition/green-tea-benefits" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">Green tea</a><span> </span>has been linked to better brain function and heart health, lower cholesterol, improved bone strength, and even anti-aging skin effects.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">Insider previously reported on<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.insider.com/unhealthy-breakfast-foods-2018-9" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">healthy alternatives</a><span> </span>to popular breakfast items that you can easily switch out to make your favorite breakfast more nutritious</p></div>oc1deanhttp://www.blogger.com/profile/02302555382262295577noreply@blogger.com0tag:blogger.com,1999:blog-151811238595694978.post-36538248466432160822024-03-18T16:10:00.001-04:002024-03-18T16:10:32.524-04:00St. John's Rehab(Toronto, Ontario) Recognized as a Leading Practice for Optimizing Virtual Care in Outpatient Rehab<h3 style="text-align: left;"><span style="color: red;"><span style="font-size: x-large;">You do realize survivors want recovery NOT 'CARE'?</span></span> Or does this hospital not know that survivors want 100% recovery? Are they that fucking stupid? And their board of directors is OK with such incompetence? 12 references to 'care'; NOT a single reference to recovery!</h3><h1 style="text-align: left;"><span style="color: red;"><b><b><span style="color: black;">Oops, I'm not playing by the polite rules of </span><span style="color: red;"><b><span style="color: black;">Dale Carnegie,</span> 'How to Win Friends and Influence People'. </b></span></b></b></span></h1>
<h1 style="text-align: left;">
<b>Telling supposedly smart stroke medical persons they know nothing about stroke survivors is a no-no even if it is true. <br /></b></h1><h1 style="text-align: left;"><b>Politeness
will never solve anything in stroke. Yes, I'm a bomb thrower and proud
of it. Someday a stroke 'leader' will try to ream me out for making them look bad by being truthful, I
look forward to that day. </b></h1><h3 style="text-align: left;"></h3><h3 style="text-align: left;"><a href="https://sunnybrook.ca/media/item.asp?c=1&i=3682&f=st-johns-rehab-leading-practice-recognition" target="_blank"><u>St. John's Rehab(Toronto, Ontario) Recognized as a Leading Practice for Optimizing Virtual Care in Outpatient Rehab</u></a></h3><h1></h1>
<p class="news_author_date">March 18, 2024</p>
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<p>In the face of the global pandemic, the Outpatient (OP)
department at St. John’s Rehab took bold steps to ensure continuity in
patient <b><span style="color: #ff00fe;">care</span></b> by implementing virtual <b><span style="color: #ff00fe;">care</span></b> for stroke patients. As the
world slowly returned to in-person appointments, the department didn't
just abandon virtual <b><span style="color: #ff00fe;">care</span></b>; instead, they embarked on a ground-breaking
journey to make virtual <b><span style="color: #ff00fe;">care</span></b> a permanent fixture in their toolkit,
leading to their recent recognition as a <b>Leading Practice for Optimizing Virtual Care in Outpatient Rehab </b>by <a href="https://healthstandards.org/?utm_term=health%20standards%20organization&utm_campaign=JR+-+Brand+Name+%26+Competitors+%5B2017%5D&utm_source=adwords&utm_medium=ppc&hsa_acc=5818132641&hsa_cam=763851743&hsa_grp=48068984061&hsa_ad=247217746540&hsa_src=g&hsa_tgt=kwd-381460046767&hsa_kw=health%20standards%20organization&hsa_mt=p&hsa_net=adwords&hsa_ver=3&gad_source=1&gclid=CjwKCAiAivGuBhBEEiwAWiFmYWpgQa6CnY7Ib5oh2_EDolxrEtf05eBZu0tmvvgulIdEalogkZMAXRoCDMsQAvD_BwE" target="_blank">Health Standards Organization</a>.</p>
<p>The initiative was founded on the principles of patient-centeredness,
appropriateness, goal-based <b><span style="color: #ff00fe;">care</span></b>, efficacy, efficiency, and best
practices for virtual <b><span style="color: #ff00fe;">care</span></b>. Drawing from resources like the Canadian
Stroke Best Practices Recommendations for Virtual <b><span style="color: #ff00fe;">Care</span></b> (2020) and the
Toronto Rehab Telerehab Toolkit V1 (2020), the OP team created an
infrastructure that not only bridged the immediate challenges posed by
the pandemic but also enhanced the way outpatient rehabilitation is
delivered.</p>
<p>A steering committee was formed, comprising the OP patient <b><span style="color: #ff00fe;">care</span></b>
manager, project manager, OT/PT/SLP professional practice leaders, a
patient partner, and a Toronto Stroke Network (TSN) representative. This
committee conducted an extensive review of best practices, available
resources, and an environmental scan, with feedback sought from current
patients and clinicians through online surveys and follow-up meetings.
The neuro team mapped the current and future states of the program,
identifying 14 improvement opportunities that were prioritized using an
effort-impact matrix.</p>
<p>These improvement opportunities were then distributed among four
interprofessional working groups, ensuring a holistic approach with
patient representation. Patient engagement was a key focus, aligning
with Health Quality Ontario’s Patient Engagement Framework.</p>
<p>Post-implementation, the impact on clinicians was significant.
Surveys and structured research interviews revealed increased knowledge
and satisfaction with VC tools, leading to a greater willingness to
provide VC. Clinicians noted the potential of VC in addressing
transportation challenges, involving family/caregivers in therapy
sessions, and extending geographical reach to patients residing farther
from the hospital.</p>
<p>Patients echoed these sentiments, highlighting the flexibility in
scheduling, improved patient-oriented <b><span style="color: #ff00fe;">care</span></b>, and the unique advantage of
assessments within their home environment. VC became a catalyst for
earlier access, enhanced patient-centeredness, interprofessional
collaboration, and effective discharge planning.</p>
<p>The success of this initiative aligns seamlessly with St. John’s
Rehab’s Strategic plan under the "Innovating Our Work" section. With
virtual <b><span style="color: #ff00fe;">care</span></b> infrastructure in place, St. John’s Rehab’s OP team has set
a new standard for outpatient rehabilitation, ensuring that the
benefits of virtual <b><span style="color: #ff00fe;">care</span></b> are maximized to deliver efficient,
patient-centered, and holistic rehabilitation services.</p></div><h3 style="text-align: left;"></h3><h3 style="text-align: left;"><br /></h3>oc1deanhttp://www.blogger.com/profile/02302555382262295577noreply@blogger.com0tag:blogger.com,1999:blog-151811238595694978.post-71239296396524851972024-03-18T15:49:00.001-04:002024-03-18T15:49:48.638-04:00Who Is at Risk of Caffeine Intoxication?<h3 style="text-align: left;"><span style="color: red;"><span style="font-size: large;">So go ask your competent? doctor </span><span style="font-size: x-large;">EXACTLY</span><span style="font-size: large;"> how many cups of coffee do you need to prevent Parkinsons and dementia. Or should you be doing decaf since caffeine does not seem to be the good thing!<br /></span></span></h3><h3 style="text-align: left;">This
will not change my mind.</h3><h3 style="text-align: left;"></h3><h3 style="text-align: left;"> I'm doing a 12 cup pot of coffee a day to lessen my chance of dementia and Parkinsons. Tell me <span style="color: red;">EXACTLY</span> how much coffee to drink for that and I'll change.</h3><h3 style="text-align: left;">I think I'm in this category: I never get the jitters or flushed skin.<br /></h3><h3><a href="http://oc1dean.blogspot.com/2017/05/genetics-determine-how-much-coffee-you.html"><u>Genetics determine how much coffee you can drink before it goes wrong</u></a></h3><h3 style="text-align: left;"> </h3><h3 style="text-align: left;"></h3><h3 style="text-align: left;"></h3><h3 style="text-align: left;"><a href="http://www.oc1dean.blogspot.com/2014/08/how-coffee-protects-against-parkinsons.html"><u>How coffee protects against Parkinson’s</u></a> Aug. 2014 </h3><h3 style="text-align: left;"><a href="http://oc1dean.blogspot.com/2013/02/5-most-surprising-reasons-to-drink.html" target="_blank"><u>Coffee May Lower Your Risk of Dementia</u></a> Feb. 2013 </h3><h3 style="text-align: left;">And this:
<a href="http://oc1dean.blogspot.com/2018/12/coffees-phenylindanes-fight-alzheimers.html"><u>Coffee's Phenylindanes Fight Alzheimer's Plaque </u></a>December 2018</h3><h3 style="text-align: left;"></h3><h3><a href="http://oc1dean.blogspot.com/2018/12/how-coffee-may-protect-brain-health-new.html"><u>How Coffee May Protect Brain Health: A New Study Suggests The Benefits Aren't Just From Caffeine</u></a> December 2018</h3><h3><a href="http://oc1dean.blogspot.com/2018/04/caffeine-causes-widespread-brain.html"><u>Caffeine causes widespread brain entropy (and that's a good thing)</u></a><u> </u></h3><h3>April 2018 <br /></h3><h3><a href="http://oc1dean.blogspot.com/2020/08/this-many-coffees-is-bad-for-your-heart.html"><u>This Many Coffees(6) Is Bad For Your Heart Health</u></a> August 2020<span style="color: red;">(I'm ignoring this one)</span><br /></h3><h3><a href="http://oc1dean.blogspot.com/2018/07/study-more-coffee-you-drink-longer-you.html"><u>Study: The More Coffee You Drink, the Longer You Live</u></a> July 2018 </h3><h3>The latest here: </h3><h3 style="text-align: left;"> </h3><h3 class="mpt-content-headline" style="text-align: left;"><u><a href="https://www.medpagetoday.com/popmedicine/cultureclinic/109185?xid=nl_medpageexclusive_2024-03-18&eun=g424561d0r&utm_source=Sailthru&utm_medium=email&utm_campaign=MPTExclusives_031824&utm_term=NL_Gen_Int_Medpage_Exclusives_Active" target="_blank">Who Is at Risk of Caffeine Intoxication?</a></u></h3><div class="mpt-content-headline" style="text-align: left;"><h3 class="mpt-content-deck" style="text-align: left;">People may not realize they may be consuming far more than the recommended daily amount</h3>
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<a href="https://www.medpagetoday.com/people/md4797/michael-depeau-wilson">Michael DePeau-Wilson</a>, Enterprise & Investigative Writer, MedPage Today <span class="mpt-content-date" content="March 14, 2024" itemprop="datePublished">
March 14, 2024
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<p><em>Welcome to Culture Clinic, </em>MedPage Today<em>'s collaboration with Northwell Health to offer a healthcare professional's take on the latest viral medical topics.</em></p>
<p>While caffeine -- usually in a cup of coffee or two -- is a
regular part of most people's daily routine, at high levels of
consumption it can have toxic effects, known as "caffeine intoxication,"
experts said.</p>
<p>A safe amount of caffeine for the average person tops out at roughly 400 mg per day -- about 4 to 5 cups of coffee, <a href="https://www.fda.gov/consumers/consumer-updates/spilling-beans-how-much-caffeine-too-much#::text=For%20healthy%20adults%2C%20the%20FDA,it%20(break%20it%20down)." target="_blank" title="Opens in a new tab or window">according to the FDA<span class="screen-readers-only">opens in a new tab or window</span></a>. However, the toxic effects of caffeine kick in with rapid consumption of about 1,200 mg -- about 12 cups of coffee.</p>
<div class="ad-slot ad box-ad rendered-ad-slot" data-pos="body" data-refreshable-ad="true" data-slot="box2" id="adSlot1"></div><p>Guy Mintz, MD, of Northwell Health Sandra Atlas Bass Heart Hospital in Manhasset, New York, told <em>MedPage Today</em>
that caffeine intoxication has a range of symptoms, from jitteriness,
elevated heart rate, and increased in blood pressure, all the way up to
palpitations, nausea, or vomiting, and even seizures.</p>
<p>"Caffeine intake of 400 mg or less per day is deemed safe and
acceptable," Mintz said. "Once you start to get above 400, people can
have various side effects, which would include all of these things,
[and] ... potential seizure."</p>
<p>Mintz noted that every individual will have a different tolerance
level, and that adolescents are especially susceptible to the risks of
caffeine intoxication because they likely have a lower tolerance
threshold for overall caffeine consumption. He recommended that younger
caffeine drinkers should consume no more than 200 mg per day.</p>
<p>Still, most people don't realize that they may be consuming more than the recommended amount of caffeine each day.</p>
<p>While people say they limit their intake to a few cups of morning or
afternoon coffee, "It's not just about coffee," Mintz said. People
unknowingly consume caffeine from other sources, such as energy drinks.
"It all adds up."</p>
<div class="ad-slot ad box-ad rendered-ad-slot" data-pos="body" data-refreshable-ad="true" data-slot="box4" id="adSlot2"></div><p>Other
sources of caffeine include that cup of tea at dinnertime or a Red Bull
to stave off the mid-afternoon lull, he said. All of those sources of
caffeine can accumulate in a person's system leading to potential
intoxication. In fact, he noted that caffeine from a single drink can
stay in a person's system for up to 9 hours.</p>
<p>In addition, these other kinds of drinks frequently contain far more caffeine than a typical cup of coffee, he warned.</p>
<p>Recently, drinks with high levels of caffeine have even been <a href="https://www.medpagetoday.com/popmedicine/cultureclinic/107188" target="_blank" title="Opens in a new tab or window">cited in wrongful death lawsuits<span class="screen-readers-only">opens in a new tab or window</span></a>
brought by people with preexisting conditions, such as long QT syndrome
type 1, that made them more susceptible to caffeine's adverse effects.
Some <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986491/" target="_blank" title="Opens in a new tab or window">research exists backing up these claims<span class="screen-readers-only">opens in a new tab or window</span></a> that caffeine can lead to death.</p>
<p>Adding to the risk of caffeine intoxication, many people <a href="https://www.ncausa.org/newsroom/nca-releases-atlas-of-american-coffee" target="_blank" title="Opens in a new tab or window">tend to consume caffeinated drinks almost every day<span class="screen-readers-only">opens in a new tab or window</span></a>, which can lead to chronic intoxication, according to Nicole Clark, MD, a neurologist at St. Peter's Health in Helena, Montana.</p>
<p>"If you have chronic intoxication you can become very dependent, just
like on any other chemical, and that causes its own set of problems,"
Clark told <em>MedPage Today.</em></p>
<div class="ad-slot ad flex-ad rendered-ad-slot" data-pos="bodytext" data-refreshable-ad="false" data-site="MedpageTextlinks" data-slot="text5" id="adSlot3"></div><p>People
tend to feel the side effects of caffeine withdrawal -- headaches,
excessive tiredness, and even feelings of depression -- after missing
just one day of their normal caffeine intake.</p>
<p>Both Clark and Mintz recommended that physicians discuss the risk of
caffeine intoxication with their patients, similar to questions
regarding alcohol consumption, during annual wellness check-ups.</p>
<p>While caffeine tolerance will be unique to each individual, Mintz said, the risk of intoxication exists for everyone.</p>
<p>"It's unclear [at] what level someone will progress to extreme
toxicity, where you're at increased risk of seizure activity," Mintz
said, "but along the way there's a lot of side effects."</p></div></div></div>oc1deanhttp://www.blogger.com/profile/02302555382262295577noreply@blogger.com0tag:blogger.com,1999:blog-151811238595694978.post-24345514261904766332024-03-18T10:18:00.001-04:002024-03-18T10:18:15.611-04:00Quality of Life After Intravenous Thrombolysis for Acute Ischemic Stroke: Results From the AcT Randomized Controlled Trial<h3 style="text-align: left;"> So everything here was a complete failure! No report or measurement of 100% recovery for anyone! In every stroke survivors opinion, anything less than 100% recovery is failure! <span style="color: red;"><span style="font-size: x-large;">GET THERE!</span></span></h3><h3 style="text-align: left;"><a href="http://oc1dean.blogspot.com/2016/10/whats-measured-improves-so-said.html"><u>“What's measured, improves.” So said management legend and author Peter F. Drucker </u></a></h3><h3 style="text-align: left;"><span style="color: red;"><span style="font-size: x-large;"> </span></span></h3><h3 class="citation__title" style="text-align: left;"><a href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.044690" target="_blank"><u>Quality of Life After Intravenous Thrombolysis for Acute Ischemic Stroke: Results From the AcT Randomized Controlled Trial</u></a></h3><div class="citation__title" style="text-align: left;"><h1 class="citation__title"><span class="citation__title-icon"><br /></span></h1><div class="loa-wrapper hidden-xs"> <div class="accordion" id="sb-1"> <div class="accordion-tabbed loa-accordion"> <div class="accordion-tabbed__tab-mobile accordion__closed "><span></span><a class="author-name accordion-tabbed__control visible-x" data-db-target-for="a1" data-id="a1" href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.044690#" title="Tolulope T. Sajobi"><span>Tolulope T. Sajobi</span><i aria-hidden="true" class="icon-Email"></i></a>, </div> <div class="accordion-tabbed__tab-mobile "><span></span><a class="author-name accordion-tabbed__control visible-x" data-db-target-for="a2" data-id="a2" href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.044690#" title="Olayinka I. Arimoro"><span>Olayinka I. Arimoro</span></a>, </div> <div class="accordion-tabbed__tab-mobile "><span></span><a class="author-name accordion-tabbed__control visible-x" data-db-target-for="a3" data-id="a3" href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.044690#" title="Ayoola Ademola"><span>Ayoola Ademola</span></a>, </div> <div class="accordion-tabbed__tab-mobile "><span></span><a class="author-name accordion-tabbed__control visible-x" data-db-target-for="a4" data-id="a4" href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.044690#" title="Nishita Singh"><span>Nishita Singh</span></a>, </div> <div class="accordion-tabbed__tab-mobile "><span></span><a class="author-name accordion-tabbed__control visible-x" data-db-target-for="a5" data-id="a5" href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.044690#" title="Fouzi Bala"><span>Fouzi Bala</span></a>, </div> <div class="accordion-tabbed__tab-mobile "><span></span><a class="author-name accordion-tabbed__control visible-x" data-db-target-for="a6" data-id="a6" href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.044690#" title="Mohammed A. Almekhlafi"><span>Mohammed A. Almekhlafi</span></a>, </div> <div class="accordion-tabbed__tab-mobile "><span></span><a class="author-name accordion-tabbed__control visible-x" data-db-target-for="a7" data-id="a7" href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.044690#" title="Yan Deschaintre"><span>Yan Deschaintre</span></a>, </div> <div class="accordion-tabbed__tab-mobile "><span></span><a class="author-name accordion-tabbed__control visible-x" data-db-target-for="a8" data-id="a8" href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.044690#" title="Shelagh B. Coutts"><span>Shelagh B. Coutts</span></a>, </div> <div class="accordion-tabbed__tab-mobile "><span></span><a class="author-name accordion-tabbed__control visible-x" data-db-target-for="a9" data-id="a9" href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.044690#" title="Sibi Thirunavukkarasu"><span>Sibi Thirunavukkarasu</span></a>, </div> <div class="accordion-tabbed__tab-mobile "><span></span><a class="author-name accordion-tabbed__control visible-x" data-db-target-for="a10" data-id="a10" href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.044690#" title="Houman Khosravani"><span>Houman Khosravani</span></a>, </div> <a aria-expanded="false" class="read-more"> <span class="ellipsis">…</span> See all authors <i class=" icon-section_arrow_d "></i></a></div> </div> </div> <div class="epub-section"><span class="epub-section__item"><span class="epub-section__state">Originally published</span><span class="epub-section__date">26 Jan 2024</span></span><span class="epub-section__item"><a class="epub-section__doi__text" href="https://doi.org/10.1161/STROKEAHA.123.044690">https://doi.org/10.1161/STROKEAHA.123.044690</a></span><span class="epub-section__item">Stroke. 2024;55:524–531</span></div><div class="article__body show-references"><div class="hlFld-Abstract"><a name="abstract"></a><div class="sectionInfo abstractSectionHeading"><h2 class="article-section__title section__title to-section" id="d55650645e1">Abstract</h2></div><div class="abstractSection abstractInFull"><div class="anchor-spacer" id="acd1e1027"></div><h3 class="article-section__title" id="d1e1027">BACKGROUND:</h3><p>Recent
evidence from thrombolysis trials indicates the noninferiority of
intravenous tenecteplase to intravenous alteplase with respect to good
functional outcomes in patients with acute stroke. We examined whether
the health-related quality of life (HRQOL) of patients with acute stroke
differs by the type of thrombolysis treatment received. In addition, we
examined the association between the modified Rankin Scale score 0 to 1
and HRQOL and patient-reported return to prebaseline stroke functioning
at 90 days.</p><div class="anchor-spacer" id="acd1e1034"></div><h3 class="article-section__title" id="d1e1034">METHODS:</h3><p>Data
were from all patients included in the AcT trial (Alteplase Compared to
Tenecteplase), a pragmatic, registry-linked randomized trial comparing
tenecteplase with alteplase. HRQOL at 90-day post-randomization was
assessed using the 5-item EuroQOL questionnaire (EQ5D), which consists
of 5 items and a visual analog scale (VAS). EQ5D index values were
estimated from the EQ5D items using the time tradeoff approach based on
Canadian norms. Tobit regression and quantile regression models were
used to evaluate the adjusted effect of tenecteplase versus alteplase
treatment on the EQ5D index values and VAS score, respectively. The
association between return to prebaseline stroke functioning and the
modified Rankin Scale score 0 to 1 and HRQOL was quantified using
correlation coefficient (<i>r</i>) with 95% CI.</p><div class="anchor-spacer" id="acd1e1045"></div><h3 class="article-section__title" id="d1e1045">RESULTS:</h3><p>Of
1577 included in the intention-to-treat analysis patients, 1503 (95.3%)
had complete data on the EQ5D. Of this, 769 (51.2%) were administered
tenecteplase and 717 (47.7%) were female. The mean EQ5D VAS score and
EQ5D index values were not significantly higher for those who received
intravenous tenecteplase compared with those who received intravenous
alteplase (<i>P</i>=0.10). Older age (<i>P</i><0.01), more severe stroke assessed using the National Institutes of Health Stroke Scale (<i>P</i><0.01), and longer stroke onset-to-needle time (<i>P</i>=0.004) were associated with lower EQ5D index and VAS scores. There was a strong association (<i>r</i>,
0.85 [95% CI, 0.81–0.89]) between patient-reported return to
prebaseline functioning and modified Rankin Scale score 0 to 1
Similarly, there was a moderate association between return to
prebaseline functioning and EQ5D index (<i>r</i>, 0.45 [95% CI, 0.40–0.49]) and EQ5D VAS scores (<i>r</i>, 0.42 [95% CI, 0.37–0.46]).</p><div class="anchor-spacer" id="acd1e1075"></div><h3 class="article-section__title" id="d1e1075">CONCLUSIONS:</h3><p>Although
there is no differential effect of thrombolysis type on
patient-reported global HRQOL and EQ 5D-5L index values in patients with
acute stroke, sex- and age-related differences in HRQOL were noted in
this study.</p><div class="anchor-spacer" id="acd1e1082"></div><h3 class="article-section__title" id="d1e1082">REGISTRATION:</h3><p>URL: <a class="references__uri" href="https://www.clinicaltrials.gov">https://www.clinicaltrials.gov</a>; Unique identifier: NCT03889249.</p></div><div class="abstractSection abstractInFull"><p></p><figure class="article__inlineFigure" id="fig0"><img alt="" class="figure__image" data-lg-src="/cms/asset/4a4ccfe1-6c88-4e63-8cb4-97d95be4d6e7/strokeaha.123.044690.fig04.jpg" src="https://www.ahajournals.org/cms/asset/7c22f079-27f4-4445-854a-9e60ff64e2ff/strokeaha.123.044690.fig04.jpg" /><div class="figure-links"><ul class="rlist--inline"><li><a href="https://www.ahajournals.org/cms/asset/ad9b0edd-4509-44da-ab37-3102b2da6c2f/strokeaha.123.044690.fig04.jpg">Download figure</a></li><li><a class="ppt-figure-link" href="https://www.ahajournals.org/action/downloadFigures?id=fig0&doi=10.1161%2FSTROKEAHA.123.044690">Download PowerPoint</a></li></ul></div></figure></div></div></div></div>oc1deanhttp://www.blogger.com/profile/02302555382262295577noreply@blogger.com0tag:blogger.com,1999:blog-151811238595694978.post-17389343296524554242024-03-17T18:39:00.003-04:002024-03-18T16:51:22.607-04:00I've studied 100-year-olds and longevity habits for 20 years: What I eat every day<h3 style="text-align: left;"> You do expect your
competent? doctor has the nutritionist create diet protocols for both the hospital meals and when you get home? Or don't you have a functioning stroke doctor?<br /></h3><h3><u><a href="https://www.msn.com/en-us/health/nutrition/i-ve-studied-100-year-olds-and-longevity-habits-for-20-years-what-i-eat-every-day/ar-BB1k0qzm?ocid=msedgdhp&pc=SMTS&cvid=7e44b47a5f06402b84f51ac45a1e823e&ei=127" target="_blank">I've studied 100-year-olds and longevity habits for 20 years: What I eat every day</a></u></h3><div style="text-align: left;"><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">When it comes to extending your lifespan, it's crucial to<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.cnbc.com/2024/01/06/harvard-expert-4-simple-ways-to-eat-for-longevity-in-2024.html?&doc=107388192" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">be cognizant about the foods</a><span> </span>you put in your body.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">Dan Buettner has made it his life's work to research the world's longest-living people. The 63-year-old coined the term "<a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.cnbc.com/2023/09/26/loma-linda-ca-what-the-only-blue-zone-in-the-us-does-for-longevity.html?&doc=107388192" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">blue zones</a>," which refers to the places around the globe where residents' lifespans exceed the average life expectancy.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">His research covered a variety of factors, including diet. But what does Buettner himself eat after a lifetime of learning about longevity?</p><p class="continue-read-break" data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; opacity: 1; orphans: 2; position: static; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">"I've spent 20 years studying the longest-lived people, and I know what they do as populations to live a long time," he tells CNBC Make It. "But I'm not one of these<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.bloomberg.com/news/articles/2023-05-22/bryan-johnson-s-anti-aging-blood-transfusion-involves-dad-and-son?leadSource=uverify%20wall" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">obsessed Silicon Valley millionaires</a><span> </span>who is sacrificing their enjoyment of daily living to see if we can tack some years on the end."</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">These are the diet decisions that Buettner, who recently released a<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://bluezoneskitchen.com/" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">line of frozen meals</a><span> </span>based on popular blue zone recipes, makes every day to stay healthy as he ages.</p><h4 style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; letter-spacing: normal; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">1. Eating within a 10- to 12-hour window</h4><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">"I know that the longest-lived people are eating most of their calories in about a 10- or 12-hour window," Buettner says. "And so I usually have just two meals a day." (<b><span style="color: red;">Well I do two meals a day, mainly so I can socialize at night with friends at live music, allowing me some alcohol.)</span></b><br /></p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">Buettner has his first meal each day around 11 a.m. and his second meal at about 7 p.m.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">"Miami nightlife kind of forces me out," the Florida resident says. "It's not exactly blue zone that way, so I tend to have breakfast at about 11."</p><h4 style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; letter-spacing: normal; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">2. Having beans for breakfast and dinner</h4><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">From his research, Buettner has learned that<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.bluezones.com/2016/06/10-things-about-beans/" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">people who eat a cup of beans a day</a><span> </span>tend to live about four years longer than those who don't.<b><span style="color: red;">(I'm not good at this.)</span></b></p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">"I always get my beans and try [to include them in] both meals," he says. "I start my day with Sardinian minestrone, which has three kinds of beans and about five kinds of vegetables."</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">He also adds capsaicin-rich red pepper flakes, which can help to<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.webmd.com/diet/health-benefits-capsaicin" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">increase metabolism</a>. Buettner tosses in some oregano and rosemary to help<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491497/" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">lower inflammation</a><span> </span>and get<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804097/" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">more antioxidants</a>.</p><h4 style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; letter-spacing: normal; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">3. Going out to eat often</h4><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">Though Buettner acknowledges that going out for dinner nearly every night doesn't align with a longevity diet, it's a part of his life that he doesn't feel a need to change.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">"It's hard to eat really healthy when you go out, no matter where you go," he says. "I try to eat plant-based."</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">When looking at a restaurant menu, he tends to gravitate toward the side dishes. A few of his favorite side dishes include:</p><div class="article-list-slot" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;"><ul style="padding-inline-start: 20px;"><li data-t="{"n":"blueLinks"}" style="font-size: 18px; line-height: 28px; margin: 10px 0px;">Cannellini beans</li><li data-t="{"n":"blueLinks"}" style="font-size: 18px; line-height: 28px; margin: 10px 0px;">Spinach</li><li data-t="{"n":"blueLinks"}" style="font-size: 18px; line-height: 28px; margin: 10px 0px;">Roasted potatoes</li></ul></div><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">He also enjoys going to Indian restaurants where he's able to find a lot of plant-based options like red or green curry tofu and chickpeas.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">"These are as satisfying as eating meat, but without any of the saturated fats," Buettner says.</p><h4 style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; letter-spacing: normal; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">4. 'Don't eat meat at all'</h4><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">"I'm about 98% plant based," he says. "I don't eat meat at all. And people in blue zones did eat a little bit of meat." <b><span style="color: red;">(I'm not good at this.)</span></b><br /></p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">While the average American eats about<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.forbes.com/sites/michelinemaynard/2018/01/02/veggies-may-be-healthier-but-in-2018-americans-will-eat-a-record-amount-of-meat/?sh=b8bc53b19b92" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">220 pounds</a><span> </span>of meat per year, blue zone residents only eat around 20 pounds of meat annually. Though he refrains from eating meat himself, Buettner says it's fine in moderation.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">"I think a longevity diet probably has room for meat once a week or so without too much harm," he says.</p></div>oc1deanhttp://www.blogger.com/profile/02302555382262295577noreply@blogger.com0tag:blogger.com,1999:blog-151811238595694978.post-52925737567734159652024-03-17T18:25:00.002-04:002024-03-17T18:25:55.457-04:00People with Alzheimer’s disease tend to be deficient in these 5 nutrients that ‘help keep brains in top condition at all ages,’ researchers say<h3 style="text-align: left;">Don't do anything with this until your competent? doctor has the nutritionist create protocol amounts for these, after testing your levels.</h3><h3 style="text-align: left;">------------------------------------------------------------------------------------ <br /></h3><h3 style="text-align: left;"><span class="ILfuVd" lang="en"><span class="hgKElc">Vitamin E toxicity is rare, but <b>occasionally high doses cause a risk of bleeding, as well as muscle weakness, fatigue, nausea, and diarrhea</b>. The greatest risk from vitamin E toxicity is bleeding. </span></span></h3><h3 style="text-align: left;"><span class="ILfuVd" lang="en"><span class="hgKElc">------------------------------------------------------------------------------------- <br /></span></span></h3><h3 data-hveid="CCQQAQ" style="text-align: left;"><div aria-controls="_-mf3ZcmPIYfaptQPtO620AI_43" aria-expanded="true" class="dnXCYb" role="button" tabindex="0"><div class="JlqpRe"><span class="JCzEY ZwRhJd"><span class="CSkcDe">What are the side effects of too much lutein?</span></span></div></div></h3><h3 id="-mf3ZcmPIYfaptQPtO620AI__18" style="text-align: left;"><div class="wDYxhc" data-md="61" style="clear: none;"><div aria-level="3" class="LGOjhe" data-attrid="wa:/description" data-hveid="CBwQAA" role="heading"><span class="ILfuVd" lang="en"><span class="hgKElc">Serious
eye symptoms such as sudden vision loss, blurred vision, tunnel vision,
eye pain or swelling, or seeing halos around lights; Serious heart
symptoms include fast, irregular, or pounding heartbeats; fluttering in
the chest; shortness of breath; sudden dizziness, lightheartedness, or
passing out.</span></span></div></div></h3><h3 style="text-align: left;"><span class="ILfuVd" lang="en"><span class="hgKElc">------------------------------------------------------------------------------------- </span></span></h3><h3 style="text-align: left;"><span class="ILfuVd" lang="en"><span class="hgKElc"> </span></span><span class="ILfuVd" lang="en"><span class="hgKElc">Luckily for those taking a zeaxanthin-based eye vitamin, <b>there are no known toxic side effects</b>
of taking too much zeaxanthin. People with healthier vision may not
need to take higher amounts of this nutrient vs. people with poor eye
health</span></span></h3><h3 style="text-align: left;"><span class="ILfuVd" lang="en"><span class="hgKElc">------------------------------------------------------------------------------------- </span></span></h3><h3 style="text-align: left;"><span class="ILfuVd" lang="en"><span class="hgKElc"> </span></span><span class="ILfuVd" lang="en"><span class="hgKElc">Lycopene is considered safe and <b>there are no established upper limits recommended for its consumption</b>. However, some cases of extremely high lycopene intake have led to slight skin discoloration.</span></span></h3><h3 style="text-align: left;"><span class="ILfuVd" lang="en"><span class="hgKElc"> </span></span><span class="ILfuVd" lang="en"><span class="hgKElc">------------------------------------------------------------------------------------- </span></span></h3><h3 data-hveid="CCEQAQ" style="text-align: left;"><div aria-controls="_Imn3ZYDgEc62ptQPhMaWqAQ_38" aria-expanded="true" class="dnXCYb" role="button" tabindex="0"><div class="JlqpRe"><span class="JCzEY ZwRhJd"><span class="CSkcDe">What does overuse of retinol look like?</span></span></div></div></h3><h3 style="text-align: left;"><span class="ILfuVd" lang="en"><span class="hgKElc">Incorrect retinol usage can cause <b>drying, flaking, shedding, redness, and irritation of the skin as well as exacerbated acne</b>. Retinol will also increase skin sensitivity to UV rays</span></span></h3><h3 style="text-align: left;"></h3><h3 style="text-align: left;"><u><a href="https://www.msn.com/en-us/health/nutrition/people-with-alzheimer-s-disease-tend-to-be-deficient-in-these-5-nutrients-that-help-keep-brains-in-top-condition-at-all-ages-researchers-say/ar-AA1fmcyz?ocid=msedgdhp&pc=SMTS&cvid=7e44b47a5f06402b84f51ac45a1e823e&ei=96" target="_blank">People with Alzheimer’s disease tend to be deficient in these 5 nutrients that ‘help keep brains in top condition at all ages,’ researchers say</a></u></h3><div style="text-align: left;"><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;"><span class="dropcap-element-slot" style="float: left; font-family: "Eb Garamond"; font-size: 64px; font-style: normal; line-height: 52px; margin-inline-end: 8px;">L</span>evels of five micronutrients are “strikingly lower” in the brains of those who have Alzheimer’s disease than in the brains of those who don’t.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">That’s according to<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357197/" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">new research</a><span> </span>published in the<span> </span><i>Journal of Alzheimer’s Disease<span> </span></i>by Virginia Tech Carilion School of Medicine professor C. Kathleen Dorey and a team of researchers.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">Scientists analyzed the brains of 31 donors, the average age of which was 75 years. Most, but not all, had died with Alzheimer’s disease. Compared to unaffected brains, they found that brains of those with the disease had around half the level of the following micronutrients—vitamins and minerals critical to the body’s function, but needed only in small amounts:</p><p class="continue-read-break" data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; opacity: 1; orphans: 2; position: static; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">• <span> </span><b><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.webmd.com/vitamins/ai/ingredientmono-554/lycopene#:~:text=Lycopene%20is%20a%20type%20of,help%20protect%20cells%20from%20damage." style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">Lycopene</a>:</b><span> </span>An antioxidant that could help protect cells from damage, lycopene gives some fruits and vegetables—like tomatoes, watermelon, red oranges, pink grapefruits, apricots, and guavas—their red hue.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">• <b><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.nhs.uk/conditions/vitamins-and-minerals/vitamin-a/" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">Retinol</a>:</b><span> </span>A form of Vitamin A that helps the immune system work properly, retinol helps you see in dim lighting and keeps skin healthy. It’s found in foods like cheese, eggs, oily fish, milk, yogurt, and liver. The body can convert beta-carotene into retinol, so indirect sources include yellow, red, and green leafy vegetables like spinach, carrots, sweet potatoes, and red peppers, as well as yellow fruits like mangos, papaya, and apricots.</p><div class="intra-article-module" data-t="{"n":"intraArticle","t":13}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; orphans: 2; position: relative; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; width: 682px; word-spacing: 0px; z-index: 97;"><div class="articlePageIntraArticleFullWidth left-image-intra-ad"><div class="intra-article-relatedcontent" style="min-height: 475px;"><div class="video-clear-div" style="clear: both; display: block;"></div><p class="related-video-divider-top video-title" data-test-id="video-embed-title" style="-webkit-box-orient: vertical; -webkit-line-clamp: 2; border-top: 1px solid rgba(0, 0, 0, 0.09); display: -webkit-box; margin-block-end: 8px; overflow: hidden; padding-top: 8px;"><img src="https://assets.msn.com/staticsb/statics/latest/icons-wc/icons/VideoBlue.svg" style="background-image: linear-gradient(white, white); background-position: center center; background-repeat: no-repeat; background-size: 8px 8px; margin-inline-end: 8px;" /><span class="related-video-title-bold" style="font-weight: 600;">Related video</span>:<span> </span>Using A.I. to detect early signs of Alzheimer's<span> </span>(KRON San Francisco)</p><div class="video-wrapper" style="height: 383.625px; position: relative; width: 682px;"><div class="videocard1PP video-embed-common related-video-divider-bottom videocardRelatedVideo" style="aspect-ratio: 16 / 9; box-sizing: content-box; height: 383.625px; margin-bottom: 32px; 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writing-mode: horizontal-tb;">symptoms start to appear.</div></div></div></div><div class="vjs-control-bar endSlate-controlbar" dir="ltr" style="background: linear-gradient(rgba(0, 0, 0, 0) 0%, rgba(0, 0, 0, 0.8) 75.47%, rgba(0, 0, 0, 0.8) 100%); border-top-left-radius: 0.6em; border-top-right-radius: 0.6em; bottom: 0px; box-sizing: inherit; display: flex; flex-wrap: wrap; height: 70px; left: 0px; opacity: 0.8; position: absolute; right: 0px; transition: visibility 0.1s ease 0s, opacity 0.1s ease 0s; visibility: visible; width: 682px; z-index: 70;"><div class="vjs-progress-control vjs-control" data-customhandled="true" data-t="{"n":"ProgressControl","t":61,"a":"click","b":59,"ext":{"videoCs":"BB1iOXxN","videoFormatCode":1006,"title":"Using A.I. to detect early signs of Alzheimer's","videoDuration":282,"playerInstanceId":"vjs_video_3_html5_api","playType":"pb","playerTech":"HTML5","pluginVersion":"HTML5","size":"682x384","videoPlayerType":"mp4:progressive","playerType":"HTML5","videoUrl":"https://prod-streaming-video-msn-com.akamaized.net/4359941a-891a-4740-ba58-133828c6f71c/c8ae230d-1790-4dd7-8142-d03bea12.ism/manifest(format=m3u8-aapl)"}}" style="-webkit-tap-highlight-color: transparent; align-items: end; box-sizing: inherit; cursor: pointer; display: flex; flex: 0 0 100%; height: 1.5em; margin: 0px; min-width: 4em; padding: 0px 8px; position: relative; text-align: center; top: 10px; touch-action: none; width: 4em; z-index: 10;"><div aria-label="Progress Bar" aria-valuemax="100" aria-valuemin="0" aria-valuenow="2.61" aria-valuetext="0:07 of 4:42" class="vjs-progress-holder vjs-slider vjs-slider-horizontal" role="slider" style="background-color: rgba(255, 255, 255, 0.4); box-sizing: inherit; cursor: pointer; flex: 1 1 auto; height: 0.5em; margin: 0px 10px; padding: 0px; position: relative; transition: all 0.2s ease 0s; user-select: none;" tabindex="0"><div class="vjs-load-progress" style="background: rgba(255, 255, 255, 0.6); border-radius: 3px; box-sizing: inherit; display: block; height: 5px; margin: 0px; padding: 0px; position: absolute; width: 68.7273px;"><span class="vjs-control-text" style="border: 0px; box-sizing: inherit; clip: rect(0px, 0px, 0px, 0px); height: 1px; overflow: hidden; padding: 0px; position: absolute; width: 1px;"><span style="box-sizing: inherit;">Loaded</span>:<span> </span><span class="vjs-control-text-loaded-percentage" style="box-sizing: inherit;">10.64%</span></span><div data-end="30.013277" data-start="0" style="background: rgba(115, 133, 159, 0.75); border-radius: 3px; box-sizing: inherit; display: block; height: 5px; left: 0px; margin: 0px; padding: 0px; position: absolute; width: 68.7273px;"></div></div><div aria-hidden="true" class="vjs-play-progress vjs-slider-bar" style="background-color: white; border-radius: 3px; box-sizing: inherit; display: block; height: 5px; margin: 0px; padding: 0px; position: absolute; width: 16.8523px;"></div></div></div><button aria-disabled="false" class="vjs-play-control vjs-control vjs-button vjs-paused" data-customhandled="true" data-t="{"n":"PlayPause","t":61,"a":"click","b":57,"ext":{"videoCs":"BB1iOXxN","videoFormatCode":1006,"title":"Using A.I. to detect early signs of Alzheimer's","videoDuration":282,"playerInstanceId":"vjs_video_3_html5_api","playType":"pb","playerTech":"HTML5","pluginVersion":"HTML5","size":"682x384","videoPlayerType":"mp4:progressive","playerType":"HTML5","videoUrl":"https://prod-streaming-video-msn-com.akamaized.net/4359941a-891a-4740-ba58-133828c6f71c/c8ae230d-1790-4dd7-8142-d03bea12.ism/manifest(format=m3u8-aapl)"}}" style="-webkit-tap-highlight-color: transparent; appearance: none; background: 0px 0px; border: medium; box-sizing: inherit; color: inherit; cursor: pointer; display: inline-block; flex: 0 0 auto; font-size: inherit; height: calc(100% - 1.5em - 10px); line-height: inherit; margin: 0px 0px 0px 10px; padding: 0px; position: relative; text-align: center; text-decoration: none; text-transform: none; top: 5px; transition: none 0s ease 0s; user-select: none; width: 4em;" title="Play" type="button"><span aria-hidden="true" class="vjs-icon-placeholder" style="box-sizing: inherit; flex: 0 0 auto;"></span><span aria-live="polite" class="vjs-control-text" style="border: 0px; box-sizing: inherit; clip: rect(0px, 0px, 0px, 0px); height: 1px; overflow: hidden; padding: 0px; position: absolute; width: 1px;">Play</span></button><button aria-disabled="false" class="vjs-control vjs-button vjs-seek-back-button" data-t="{"n":"SeekBack","t":61,"a":"click","b":59,"ext":{"videoCs":"BB1iOXxN","videoFormatCode":1006,"title":"Using A.I. to detect early signs of Alzheimer's","videoDuration":282,"playerInstanceId":"","playType":"pb","playerTech":"HTML5","pluginVersion":"HTML5","size":"682x384","videoPlayerType":"mp4:progressive","playerType":"HTML5","videoUrl":"https://prod-streaming-video-msn-com.akamaized.net/fba407b3-a285-4cec-9a32-e4892120563f/c8ae230d-1790-4dd7-8142-d03bea1230b8.mp4"}}" style="-webkit-tap-highlight-color: transparent; appearance: none; background: 0px 0px; border: medium; box-sizing: inherit; color: inherit; cursor: pointer; display: inline-block; flex: 0 0 auto; font-size: inherit; height: calc(100% - 1.5em - 10px); line-height: inherit; margin: 0px; padding: 0px; position: relative; text-align: center; text-decoration: none; text-transform: none; top: 5px; transition: none 0s ease 0s; user-select: none; width: 4em;" title="Seek Back" type="button"><img src="https://assets.msn.com/staticsb/statics/latest/views/icons/video/videoSeekBack.svg" style="box-sizing: inherit;" /></button><button aria-disabled="false" class="vjs-control vjs-button vjs-seek-forward-button" data-t="{"n":"SeekForward","t":61,"a":"click","b":59,"ext":{"videoCs":"BB1iOXxN","videoFormatCode":1006,"title":"Using A.I. to detect early signs of Alzheimer's","videoDuration":282,"playerInstanceId":"","playType":"pb","playerTech":"HTML5","pluginVersion":"HTML5","size":"682x384","videoPlayerType":"mp4:progressive","playerType":"HTML5","videoUrl":"https://prod-streaming-video-msn-com.akamaized.net/fba407b3-a285-4cec-9a32-e4892120563f/c8ae230d-1790-4dd7-8142-d03bea1230b8.mp4"}}" style="-webkit-tap-highlight-color: transparent; appearance: none; background: 0px 0px; border: medium; box-sizing: inherit; color: inherit; cursor: pointer; display: inline-block; flex: 0 0 auto; font-size: inherit; height: calc(100% - 1.5em - 10px); line-height: inherit; margin: 0px; padding: 0px; position: relative; text-align: center; text-decoration: none; text-transform: none; top: 5px; transition: none 0s ease 0s; user-select: none; width: 4em;" title="Seek Forward" type="button"><img src="https://assets.msn.com/staticsb/statics/latest/views/icons/video/videoSeekForward.svg" style="box-sizing: inherit;" /></button><div class="vjs-current-time vjs-time-control vjs-control" style="-webkit-tap-highlight-color: transparent; box-sizing: inherit; display: block; flex: 0 0 auto; font-size: 1.5em; height: calc(100% - 1.5em - 10px); line-height: 3em; margin: 0px; min-width: 2em; padding: 0px 0.4em; position: relative; text-align: center; top: 5px; width: auto;"><span class="vjs-control-text" role="presentation" style="border: 0px; box-sizing: inherit; clip: rect(0px, 0px, 0px, 0px); height: 1px; overflow: hidden; padding: 0px; position: absolute; width: 1px;">Current Time </span><span aria-live="off" class="vjs-current-time-display" role="presentation" style="box-sizing: inherit;">0:07</span></div><div aria-hidden="true" class="vjs-time-control vjs-time-divider" style="box-sizing: inherit; display: block; flex: 0 0 auto; font-size: 1.5em; height: calc(100% - 1.5em - 10px); line-height: 3em; margin-top: 5px; min-width: 0.5em; padding: 0px; top: 5px; width: auto;"><div style="box-sizing: inherit;"><span style="box-sizing: inherit;">/</span></div></div><div class="vjs-duration vjs-time-control vjs-control" style="-webkit-tap-highlight-color: transparent; box-sizing: inherit; display: block; flex: 0 0 auto; font-size: 1.5em; height: calc(100% - 1.5em - 10px); line-height: 3em; margin: 0px; min-width: 2em; padding: 0px 0.4em; position: relative; text-align: center; top: 5px; width: auto;"><span class="vjs-control-text" role="presentation" style="border: 0px; box-sizing: inherit; clip: rect(0px, 0px, 0px, 0px); height: 1px; overflow: hidden; padding: 0px; position: absolute; width: 1px;">Duration </span><span aria-live="off" class="vjs-duration-display" role="presentation" style="box-sizing: inherit;">4:42</span></div><div class="vjs-controlBar-spacing" style="box-sizing: inherit; flex: 1 1 auto;"></div><div aria-label="QualitySettings" class="vjs-quality-menu-button vjs-menu-button vjs-menu-button-popup vjs-control vjs-button" data-customhandled="true" data-t="{"n":"QualityMenuButton","t":61,"a":"click","b":90,"ext":{"videoCs":"BB1iOXxN","videoFormatCode":1006,"title":"Using A.I. to detect early signs of Alzheimer's","videoDuration":282,"playerInstanceId":"vjs_video_3_html5_api","playType":"pb","playerTech":"HTML5","pluginVersion":"HTML5","size":"682x384","videoPlayerType":"mp4:progressive","playerType":"HTML5","videoUrl":"https://prod-streaming-video-msn-com.akamaized.net/4359941a-891a-4740-ba58-133828c6f71c/c8ae230d-1790-4dd7-8142-d03bea12.ism/manifest(format=m3u8-aapl)"}}" style="-webkit-tap-highlight-color: transparent; box-sizing: inherit; cursor: pointer; flex: 0 0 auto; height: calc(100% - 1.5em - 10px); margin: 0px; padding: 0px; position: relative; text-align: center; top: 5px; width: 4em;"><button aria-disabled="false" aria-expanded="false" aria-haspopup="true" class="vjs-quality-menu-button vjs-menu-button vjs-menu-button-popup vjs-button" style="appearance: none; background: 0px 0px; border: medium; box-sizing: inherit; color: inherit; cursor: pointer; display: inline-block; font-size: inherit; height: 45px; line-height: inherit; text-decoration: none; text-transform: none; transition: none 0s ease 0s; user-select: none; width: 40px;" title="Quality Settings" type="button"><span aria-hidden="true" class="vjs-icon-placeholder" style="box-sizing: inherit;"></span><span aria-live="polite" class="vjs-control-text" style="border: 0px; box-sizing: inherit; clip: rect(0px, 0px, 0px, 0px); height: 1px; overflow: hidden; padding: 0px; position: absolute; width: 1px;">Quality Settings</span></button></div><div class="vjs-subs-caps-button vjs-menu-button vjs-menu-button-popup vjs-control vjs-button" data-customhandled="true" data-t="{"n":"SubsCapsButton","t":61,"a":"click","b":61,"ext":{"videoCs":"BB1iOXxN","videoFormatCode":1006,"title":"Using A.I. to detect early signs of Alzheimer's","videoDuration":282,"playerInstanceId":"vjs_video_3_html5_api","playType":"pb","playerTech":"HTML5","pluginVersion":"HTML5","size":"682x384","videoPlayerType":"mp4:progressive","playerType":"HTML5","videoUrl":"https://prod-streaming-video-msn-com.akamaized.net/4359941a-891a-4740-ba58-133828c6f71c/c8ae230d-1790-4dd7-8142-d03bea12.ism/manifest(format=m3u8-aapl)"}}" style="-webkit-tap-highlight-color: transparent; box-sizing: inherit; cursor: pointer; flex: 0 0 auto; height: calc(100% - 1.5em - 10px); margin: 0px; padding: 0px; position: relative; text-align: center; top: 5px; width: 4em;"><button aria-disabled="false" aria-expanded="false" aria-haspopup="true" class="vjs-subs-caps-button vjs-menu-button vjs-menu-button-popup vjs-button" style="appearance: none; background: 0px 0px; border: medium; box-sizing: inherit; color: inherit; cursor: pointer; display: inline-block; font-size: inherit; height: 45px; line-height: inherit; text-decoration: none; text-transform: none; transition: none 0s ease 0s; user-select: none; width: 40px;" title="Captions" type="button"><span aria-hidden="true" class="vjs-icon-placeholder" style="box-sizing: inherit;"></span><span aria-live="polite" class="vjs-control-text" style="border: 0px; box-sizing: inherit; clip: rect(0px, 0px, 0px, 0px); height: 1px; overflow: hidden; padding: 0px; position: absolute; width: 1px;">Captions</span></button></div><button aria-disabled="false" class="vjs-fullscreen-control vjs-control vjs-button" data-customhandled="true" data-t="{"n":"FullscreenToggle","t":61,"a":"click","b":62,"ext":{"videoCs":"BB1iOXxN","videoFormatCode":1006,"title":"Using A.I. to detect early signs of Alzheimer's","videoDuration":282,"playerInstanceId":"vjs_video_3_html5_api","playType":"pb","playerTech":"HTML5","pluginVersion":"HTML5","size":"682x384","videoPlayerType":"mp4:progressive","playerType":"HTML5","videoUrl":"https://prod-streaming-video-msn-com.akamaized.net/4359941a-891a-4740-ba58-133828c6f71c/c8ae230d-1790-4dd7-8142-d03bea12.ism/manifest(format=m3u8-aapl)"}}" style="-webkit-tap-highlight-color: transparent; appearance: none; background: 0px 0px; border: medium; box-sizing: inherit; color: inherit; cursor: pointer; display: inline-block; flex: 0 0 auto; font-size: inherit; height: calc(100% - 1.5em - 10px); line-height: inherit; margin: 0px; padding: 0px; position: relative; text-align: center; text-decoration: none; text-transform: none; top: 5px; transition: none 0s ease 0s; user-select: none; width: 4em;" title="Fullscreen" type="button"><span aria-hidden="true" class="vjs-icon-placeholder" style="box-sizing: inherit;"></span><span aria-live="polite" class="vjs-control-text" style="border: 0px; box-sizing: inherit; clip: rect(0px, 0px, 0px, 0px); height: 1px; overflow: hidden; padding: 0px; position: absolute; width: 1px;">Fullscreen</span></button><div class="vjs-volumePanel-placeholder" style="box-sizing: inherit; width: 4.8em;"></div></div><div class="vjs-title-bar" style="background: none; box-sizing: inherit; display: block; flex-wrap: wrap; font-family: "Segoe UI", Tahoma, Geneva, Verdana, sans-serif; font-weight: 700; height: auto; left: 0px; max-height: none; min-height: 2em; opacity: 1; padding: 16px; pointer-events: none; position: absolute; top: 0px; transition: visibility 0.1s ease 0s, opacity 0.1s ease 0s; visibility: visible; width: 682px; z-index: 1;"><div class="vjs-title-provider" style="box-sizing: inherit; text-align: left;"><img alt="" class="vjs-title-provider-img" src="https://img-s-msn-com.akamaized.net/tenant/amp/entityid/AAKX0Vq.img?w=16&h=16&q=60&m=6&f=jpg&u=t" style="box-sizing: inherit; vertical-align: middle;" /><span class="vjs-title-provider-name" face=""Segoe UI Variable Static Text", Tahoma, Geneva, Verdana, sans-serif" style="box-sizing: inherit; font-size: 14px; font-weight: 400; margin-left: 6px; text-align: left; vertical-align: middle;">KRON San Francisco</span></div><div class="vjs-title-text" style="-webkit-box-orient: vertical; -webkit-line-clamp: 2; box-sizing: inherit; display: -webkit-box; font-family: "Segoe UI"; font-size: 20px; font-weight: 600; 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display: flex; gap: 10px; justify-content: space-between; list-style-type: none; margin-bottom: 0px; margin-top: 4px; padding: 0px;"><li style="border-radius: 4px; border: 2px solid rgba(255, 255, 255, 0.4); cursor: default; height: 135px; width: 235px;"><a data-t="{"n":"relatedPlayListSlate","t":61,"a":"click","d":"https://www.msn.com/en-us/video/health/%E2%80%98first-step%E2%80%99-using-ai-on-routine-clinical-data-to-identify-alzheimer%E2%80%99s-disease-early/vi-BB1jT6xe?ocid=msedgdhp"}" href="https://www.msn.com/en-us/video/health/%E2%80%98first-step%E2%80%99-using-ai-on-routine-clinical-data-to-identify-alzheimer%E2%80%99s-disease-early/vi-BB1jT6xe?ocid=msedgdhp" role="link" target="_blank"><div class="playlist-thumbnail" style="height: 135px; overflow: hidden; position: relative; width: 204.159px;"><img alt="‘First Step’ Using AI on Routine Clinical Data to Identify Alzheimer’s Disease Early" src="https://img-s-msn-com.akamaized.net/tenant/amp/entityid/BB1jT4BH.img" style="aspect-ratio: 16 / 9; border-radius: 4px; display: block; height: 135px; opacity: 0.9; width: 204.159px;" title="‘First Step’ Using AI on Routine Clinical Data to Identify Alzheimer’s Disease Early" /><div class="thumbnail-overlay" style="backdrop-filter: blur(10px); background: rgba(0, 0, 0, 0.55); color: white; display: flex; flex-direction: column; height: 135px; inset: 0px; opacity: 0; position: absolute; transition: all 0.5s ease 0s; width: 204.159px;"><div class="thumbnail-abstract" style="display: flex; flex-direction: column; margin: 12px; position: absolute; top: 0px;"><span class="thumbnail-abstract-subhead" style="align-items: center; color: white; display: flex; font-size: 12px; font-style: normal; font-weight: 400; line-height: 16px; margin-bottom: 12px; opacity: 0.8;"><img alt="Dailymotion/" src="https://img-s-msn-com.akamaized.net/tenant/amp/entityid/AALnInq.img" style="aspect-ratio: 16 / 9; border-radius: 4px; display: block; height: 16px; left: 0px; margin-right: 6px; opacity: 0.9; top: 0px; width: 16px;" />Dailymotion</span><span class="thumbnail-title" role="heading" style="-webkit-box-orient: vertical; -webkit-line-clamp: 2; color: #fbfbfb; display: -webkit-box; font-size: 14px; font-weight: 600; line-height: 20px; overflow: hidden; text-overflow: ellipsis;">‘First Step’ Using AI on Routine Clinical Data to Identify Alzheimer’s Disease Early</span></div><div class="thumbnail-abstract-timer" style="align-items: center; background: rgba(0, 0, 0, 0.6); border-radius: 4px; bottom: 0px; display: flex; flex-direction: row; font-size: 12px; font-weight: 600; height: 20px; line-height: 16px; margin: 12px; padding: 2px 8px 2px 4px; position: absolute; width: 54px;"><span style="height: 12px; margin: 4px 6px; width: 12px;"><svg fill="none" height="12" viewbox="0 0 12 12" width="12" xmlns="http://www.w3.org/2000/svg"><path d="M6 0C9.31371 0 12 2.68629 12 6C12 9.31371 9.31371 12 6 12C2.68629 12 0 9.31371 0 6C0 2.68629 2.68629 0 6 0ZM6 1C3.23858 1 1 3.23858 1 6C1 8.76142 3.23858 11 6 11C8.76142 11 11 8.76142 11 6C11 3.23858 8.76142 1 6 1ZM5.50153 3C5.74699 3 5.95114 3.17688 5.99347 3.41012L6.00153 3.5V6H7.5C7.77614 6 8 6.22386 8 6.5C8 6.74546 7.82312 6.94961 7.58988 6.99194L7.5 7H5.50153C5.25607 7 5.05192 6.82312 5.00958 6.58988L5.00153 6.5V3.5C5.00153 3.22386 5.22538 3 5.50153 3Z" fill="white"></path></svg></span>1:12</div></div></div></a></li><li style="border-radius: 4px; border: 2px solid rgba(255, 255, 255, 0.4); cursor: default; height: 135px; width: 235px;"><a data-t="{"n":"relatedPlayListSlate","t":61,"a":"click","d":"https://www.msn.com/en-us/video/health/study-suggests-strawberries-may-boost-cognitive-health/vi-BB1jYmNw?ocid=msedgdhp"}" href="https://www.msn.com/en-us/video/health/study-suggests-strawberries-may-boost-cognitive-health/vi-BB1jYmNw?ocid=msedgdhp" role="link" target="_blank"><div class="playlist-thumbnail" style="height: 135px; overflow: hidden; position: relative; width: 204.159px;"><img alt="Study Suggests Strawberries May Boost Cognitive Health" src="https://img-s-msn-com.akamaized.net/tenant/amp/entityid/BB1jYkAa.img" style="aspect-ratio: 16 / 9; border-radius: 4px; display: block; height: 135px; opacity: 0.9; width: 204.159px;" title="Study Suggests Strawberries May Boost Cognitive Health" /><div class="thumbnail-overlay" style="backdrop-filter: blur(10px); background: rgba(0, 0, 0, 0.55); color: white; display: flex; flex-direction: column; height: 135px; inset: 0px; opacity: 0; position: absolute; transition: all 0.5s ease 0s; width: 204.159px;"><div class="thumbnail-abstract" style="display: flex; flex-direction: column; margin: 12px; position: absolute; top: 0px;"><span class="thumbnail-abstract-subhead" style="align-items: center; color: white; display: flex; font-size: 12px; font-style: normal; font-weight: 400; line-height: 16px; margin-bottom: 12px; opacity: 0.8;"><img alt="Money Talks News/" src="https://img-s-msn-com.akamaized.net/tenant/amp/entityid/AA1aNqsY.img" style="aspect-ratio: 16 / 9; border-radius: 4px; display: block; height: 16px; left: 0px; margin-right: 6px; opacity: 0.9; top: 0px; width: 16px;" />Money Talks News</span><span class="thumbnail-title" role="heading" style="-webkit-box-orient: vertical; -webkit-line-clamp: 2; color: #fbfbfb; display: -webkit-box; font-size: 14px; font-weight: 600; line-height: 20px; overflow: hidden; text-overflow: ellipsis;">Study Suggests Strawberries May Boost Cognitive Health</span></div><div class="thumbnail-abstract-timer" style="align-items: center; background: rgba(0, 0, 0, 0.6); border-radius: 4px; bottom: 0px; display: flex; flex-direction: row; font-size: 12px; font-weight: 600; height: 20px; line-height: 16px; margin: 12px; padding: 2px 8px 2px 4px; position: absolute; width: 54px;"><span style="height: 12px; margin: 4px 6px; width: 12px;"><svg fill="none" height="12" viewbox="0 0 12 12" width="12" xmlns="http://www.w3.org/2000/svg"><path d="M6 0C9.31371 0 12 2.68629 12 6C12 9.31371 9.31371 12 6 12C2.68629 12 0 9.31371 0 6C0 2.68629 2.68629 0 6 0ZM6 1C3.23858 1 1 3.23858 1 6C1 8.76142 3.23858 11 6 11C8.76142 11 11 8.76142 11 6C11 3.23858 8.76142 1 6 1ZM5.50153 3C5.74699 3 5.95114 3.17688 5.99347 3.41012L6.00153 3.5V6H7.5C7.77614 6 8 6.22386 8 6.5C8 6.74546 7.82312 6.94961 7.58988 6.99194L7.5 7H5.50153C5.25607 7 5.05192 6.82312 5.00958 6.58988L5.00153 6.5V3.5C5.00153 3.22386 5.22538 3 5.50153 3Z" fill="white"></path></svg></span>1:30</div></div></div></a></li><li style="border-radius: 4px; border: 2px solid rgba(255, 255, 255, 0.4); cursor: default; height: 135px; width: 235px;"><a data-t="{"n":"relatedPlayListSlate","t":61,"a":"click","d":"https://www.msn.com/en-us/video/health/alzheimer%E2%80%99s-study-looking-for-more-diversity/vi-BB1jrG3s?ocid=msedgdhp"}" href="https://www.msn.com/en-us/video/health/alzheimer%E2%80%99s-study-looking-for-more-diversity/vi-BB1jrG3s?ocid=msedgdhp" role="link" target="_blank"><div class="playlist-thumbnail" style="height: 135px; overflow: hidden; position: relative; width: 204.159px;"><img alt="Alzheimer’s study looking for more diversity" src="https://img-s-msn-com.akamaized.net/tenant/amp/entityid/BB1jrMUo.img" style="aspect-ratio: 16 / 9; border-radius: 4px; display: block; height: 135px; opacity: 0.9; width: 204.159px;" title="Alzheimer’s study looking for more diversity" /><div class="thumbnail-overlay" style="backdrop-filter: blur(10px); background: rgba(0, 0, 0, 0.55); color: white; display: flex; flex-direction: column; height: 135px; inset: 0px; opacity: 0; position: absolute; transition: all 0.5s ease 0s; width: 204.159px;"><div class="thumbnail-abstract" style="display: flex; flex-direction: column; margin: 12px; position: absolute; top: 0px;"><span class="thumbnail-abstract-subhead" style="align-items: center; color: white; display: flex; font-size: 12px; font-style: normal; font-weight: 400; line-height: 16px; margin-bottom: 12px; opacity: 0.8;"><img alt="CityNews/" src="https://img-s-msn-com.akamaized.net/tenant/amp/entityid/AAx3mgu.img" style="aspect-ratio: 16 / 9; border-radius: 4px; display: block; height: 16px; left: 0px; margin-right: 6px; opacity: 0.9; top: 0px; width: 16px;" />CityNews</span><span class="thumbnail-title" role="heading" style="-webkit-box-orient: vertical; -webkit-line-clamp: 2; color: #fbfbfb; display: -webkit-box; font-size: 14px; font-weight: 600; line-height: 20px; overflow: hidden; text-overflow: ellipsis;">Alzheimer’s study looking for more diversity</span></div><div class="thumbnail-abstract-timer" style="align-items: center; background: rgba(0, 0, 0, 0.6); border-radius: 4px; bottom: 0px; display: flex; flex-direction: row; font-size: 12px; font-weight: 600; height: 20px; line-height: 16px; margin: 12px; padding: 2px 8px 2px 4px; position: absolute; width: 54px;"><span style="height: 12px; margin: 4px 6px; width: 12px;"><svg fill="none" height="12" viewbox="0 0 12 12" width="12" xmlns="http://www.w3.org/2000/svg"><path d="M6 0C9.31371 0 12 2.68629 12 6C12 9.31371 9.31371 12 6 12C2.68629 12 0 9.31371 0 6C0 2.68629 2.68629 0 6 0ZM6 1C3.23858 1 1 3.23858 1 6C1 8.76142 3.23858 11 6 11C8.76142 11 11 8.76142 11 6C11 3.23858 8.76142 1 6 1ZM5.50153 3C5.74699 3 5.95114 3.17688 5.99347 3.41012L6.00153 3.5V6H7.5C7.77614 6 8 6.22386 8 6.5C8 6.74546 7.82312 6.94961 7.58988 6.99194L7.5 7H5.50153C5.25607 7 5.05192 6.82312 5.00958 6.58988L5.00153 6.5V3.5C5.00153 3.22386 5.22538 3 5.50153 3Z" fill="white"></path></svg></span>2:45</div></div></div></a></li></ul></div></div></div><div class="video-clear-div" style="clear: both; display: block;"></div></div></div></div><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">• <b><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.webmd.com/vitamins/ai/ingredientmono-754/lutein#:~:text=Lutein%20is%20one%20of%20two,grapes%2C%20zucchini%2C%20and%20squash." style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">Lutein</a>:</b><span> </span>Often referred to as the “eye vitamin,” lutein is thought to protect eye tissue from sun damage. You can find it in foods like egg yolks, spinach, kale, corn, orange peppers, kiwis, grapes, zucchinis, and squash.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;"></p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">• <b><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.webmd.com/vitamins/ai/ingredientmono-1655/zeaxanthin#:~:text=Zeaxanthin%20is%20a%20type%20of,eye%20tissues%20from%20sunlight%20damage." style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">Zeaxanthin</a>:</b><span> </span>An antioxidant, zeaxanthin is known to protect eye tissues from the sun. It’s found in eggs, oranges, grapes, corn, goji berries, mango, and orange peppers.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">• <b><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.hsph.harvard.edu/nutritionsource/vitamin-e/" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">Vitamin E</a>:</b><span> </span>Also an antioxidant, Vitamin E keeps free radicals in check, improves immune function, and can prevent clots from forming in the arteries of the heart. It can be found in plant-based oils, nuts, seeds, fruits, and vegetables like sunflower oil, soybean oil, almonds, peanuts, spinach, pumpkin, red bell peppers, asparagus, mangoes, and avocados. </p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">All five micronutrients are antioxidants, substances that may prevent or delay some cell damage. Lycopene, lutein, and zeaxanthin are also carotenoids, nutrient-rich pigments found in fruits and vegetables. Other large studies have found that the risk of developing Alzheimer’s disease was “significantly lower” in those who ate diets rich in carotenoids, or who had high levels of lutein and zeaxanthin in their blood or retina, according to Dorey.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">“This study, for the first time, demonstrates deficits in important dietary antioxidants in Alzheimer’s brains,” Dorey said in a<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.eurekalert.org/news-releases/998575" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">news release about the study</a>.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">“We believe eating carotenoid-rich diets will help keep brains in top condition at all ages,” she added.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">The results should come as no surprise. Multiple studies have found that those who follow the<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581900/" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">MIND</a><span> </span>(Mediterranean/<a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.nhlbi.nih.gov/education/dash-eating-plan" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">Dietary Approaches to Stop Hypertension Diet</a><span> </span>Intervention for Neurodegenerative Delay) diet—which emphasizes the consumption of antioxidant-rich fruits, vegetables, legumes, nuts, and fish, with very little meat, dairy, and sweets—had a lower risk of developing Alzheimer’s disease, better cognitive function prior to death, and fewer signs of Alzheimer’s disease in those who did develop the condition.</p><h2 class="wp-block-heading article-sub-heading" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Eb Garamond"; font-size: 30px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 500; letter-spacing: normal; line-height: 38px; margin-bottom: 24px; margin-top: 48px; orphans: 2; position: relative; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">How antioxidants play a role in Alzheimer's disease</h2><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">Scientists aren’t fully sure what causes the cell death and tissue loss that occurs in the brains of Alzheimer’s disease patients. But they believe it involves the buildup of amyloid plaques and “tau tangles”—both types of protein clumps—as the brain loses its ability to properly rid itself of such debris.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">But multiple factors play into the disease process, Dorey and colleagues write. Other processes that potentially contribute include mitochondrial dysfunction, inflammation, and oxidative damage. Because antioxidants reduce such damage, a deficiency can make the brain more frail and thinking more challenging, and contribute to the development of Alzheimer’s disease, they assert.</p><h2 class="wp-block-heading article-sub-heading" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Eb Garamond"; font-size: 30px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 500; letter-spacing: normal; line-height: 38px; margin-bottom: 24px; margin-top: 48px; orphans: 2; position: relative; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">Signs of Alzheimer’s disease</h2><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">Those who are concerned they or a loved one might have Alzheimer’s or another form of dementia should talk to their doctor, who may recommend they see another specialist, like a neuropsychologist or a neurologist.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">Warning signs of the condition,<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.aarp.org/caregiving/health/info-2019/dementia-warning-signs.html" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">according to the AARP</a>, include:</p><div class="intra-article-module" data-t="{"n":"intraArticle","t":13}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; orphans: 2; position: relative; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; width: 682px; word-spacing: 0px; z-index: 97;"></div><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">• Difficulty performing daily tasks like keeping track of bills and following a recipe while cooking</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">• Repetition, such as asking the same question over and over and telling the same story multiple times</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">• Struggling to find the right word</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">• Getting lost</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">• Personality changes, such as becoming more anxious, confused, afraid, or paranoid</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">• Confusion about time and place, especially if someone can’t remember where they are or how they got there</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">• Misplacing items in unusual areas</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">• Trouble with hygiene</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">• Trouble with handling money</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">• Sudden loss of things one is usually interested in, including family, friends, work, and social events</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">• Forgetting old memories</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">This story was originally featured on<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://fortune.com/well/2023/08/16/alzheimers-disease-dementia-patients-deficient-5-nutrients-research-brain-cognitive-health-antioxidants-carotenoids/" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">Fortune.com</a></p></div>oc1deanhttp://www.blogger.com/profile/02302555382262295577noreply@blogger.com0tag:blogger.com,1999:blog-151811238595694978.post-51127783367214479172024-03-17T17:50:00.001-04:002024-03-17T18:02:15.905-04:00Massive Study Pinpoints Specific Gut Bacteria Linked to Alzheimer's<h3 style="text-align: left;"> Is your competent? doctor and hospital ensuring further research occurs to solve this?<br /></h3><h3><u><a href="https://www.msn.com/en-us/health/medical/massive-study-pinpoints-specific-gut-bacteria-linked-to-alzheimer-s/ar-AA1hk0io?ocid=msedgdhp&pc=SMTS&cvid=7e44b47a5f06402b84f51ac45a1e823e&ei=76" target="_blank">Massive Study Pinpoints Specific Gut Bacteria Linked to Alzheimer's</a></u></h3><div style="text-align: left;"><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;"><span class="dropcap-element-slot" style="float: left; font-family: "Eb Garamond"; font-size: 64px; font-style: normal; line-height: 52px; margin-inline-end: 8px;">T</span>ensions between the brain, the gut, and the makeup of its microbial inhabitants appear to play a critical role in the<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.sciencealert.com/evidence-piles-up-linking-parkinson-s-disease-with-the-bacteria-in-our-gut" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">development of neurodegenerative conditions</a>.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">While evidence favoring a link between the microbiota-gut-brain axis (MGBA) and<span> </span><a class="lar_link lar_link_outgoing" data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.sciencealert.com/go/IaO" rel="nofollow" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">Alzheimer's</a><span> </span>disease continues to grow, the exact mechanism behind the relationship is<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.sciencealert.com/alzheimers-may-not-actually-be-a-brain-disease-expert-says" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">still poorly understood</a>.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">The puzzle pieces have so far been frustratingly incoherent, involving seemingly unrelated factors as<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.sciencealert.com/we-may-finally-understand-how-the-tangled-proteins-in-dementia-cause-cells-to-die" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">tangled proteins</a><span> </span>inside nervous tissue to<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.sciencealert.com/alzheimers-disease-beta-amyloid-source-outside-brain" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">suspect gut microbes</a><span> </span>to<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.sciencealert.com/new-research-could-radically-change-our-thinking-on-tackling-alzheimer-s" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">subtle differences</a><span> </span>in fat-transporting molecules.</p><p class="continue-read-break" data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; opacity: 1; orphans: 2; position: static; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">Using the largest ever genome-wide association study of human gut microflora, a team of researchers from the US sought out a more explicit relationship between Alzheimer's disease and the mix of organisms living inside the digestive system.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">Their analysis, published in March 2023, uncovered not only a genetic connection between different genera of gut bacteria and a diagnosis of Alzheimer's but also a link between the microbes and a genetic risk factor for the neurodegenerative disorder.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">The study further emphasizes the interplay of genetic factors and inflammatory gut microflora in healthy brain function.</p><p class="" data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">Early in our development, our bodies are colonized by an assortment of bacteria, fungi, and<span> </span><a class="lar_link lar_link_outgoing" data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.sciencealert.com/virus" rel="nofollow" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">viruses</a><span> </span>that strike a tentative truce with the immune system. For the most part, this arrangement is mutually beneficial. The microbes get a place to live, and we get a front-line defense of tiny occupants willing to protect their home.</p><div class="intra-article-module" data-t="{"n":"intraArticle","t":13}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; orphans: 2; position: relative; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; width: 682px; word-spacing: 0px; z-index: 97;"><div class="articlePageIntraArticleFullWidth left-image-intra-ad"><div class="intra-article-relatedcontent" style="min-height: 475px;"><div class="video-clear-div" style="clear: both; display: block;"></div><p class="related-video-divider-top video-title" data-test-id="video-embed-title" style="-webkit-box-orient: vertical; -webkit-line-clamp: 2; border-top: 1px solid rgba(0, 0, 0, 0.09); display: -webkit-box; margin-block-end: 8px; overflow: hidden; padding-top: 8px;"><img src="https://assets.msn.com/staticsb/statics/latest/icons-wc/icons/VideoBlue.svg" style="background-image: linear-gradient(white, white); background-position: center center; background-repeat: no-repeat; background-size: 8px 8px; margin-inline-end: 8px;" /><span class="related-video-title-bold" style="font-weight: 600;">Related video</span>:<span> </span>Study: Daily fibre supplement improves older adults' brain function<span> </span>(WION)</p><div class="video-wrapper " style="height: 383.625px; position: relative; width: 682px;"><div class=" videocard1PP video-embed-common related-video-divider-bottom videocardRelatedVideo" style="aspect-ratio: 16 / 9; box-sizing: content-box !important; height: 383.625px; margin-bottom: 32px; position: relative; width: 682px;"><div class=" content-video-container large-title " data-t="{"n":"ContentVideoPlayer","t":61,"c.i":"BB1jdJ13","c.l":false,"c.t":61,"c.v":"video","c.c":"watch","c.b":"WION","c.bi":"BBX0Vhv","ext":{"videoId":"BB1jdJ13","videoCs":"BBX0Vhv","eventType":31,"timeElasped":91,"videoFormatCode":1006,"title":"Study: Daily fibre supplement improves older adults' brain function","videoDuration":95,"fr":"en-us_health","playType":"embed","playerTech":"MSNPlayer","size":"682x384","isContinuous":false,"isMuted":true,"playDuration":92,"inline":true,"videoPlayerType":"BingMM","videoUrl":"https://www.wionews.com/videos/study-daily-fibre-supplement-improves-older-adults-brain-function-695956","perf":{}},"m.c":false,"c.hl":"Study: Daily fibre supplement improves older adults' brain function"}" style="aspect-ratio: 16 / 9; height: 383.625px; position: relative; width: 682px;"><div aria-label="Study: Daily fibre supplement improves older adults' brain function Video Player" class="video-js vjs-msn vjs-fill vjs_video_3-dimensions vjs-controls-enabled vjs-touch-enabled vjs-workinghover vjs-v7 vjs-qualitymenu vjs-telemetry vjs-has-started vjs-hide-bigplaybutton vjs-layout-medium vjs-user-active vjs-paused" data-setup="{ "inactivityTimeout": 0 }" id="vjs_video_3" lang="en-us" poster="https://img-s-msn-com.akamaized.net/tenant/amp/entityid/BB1jduId.img?w=0&h=0&q=60&m=6&f=jpg&u=t" role="region" style="background-color: black; border-radius: var(--video-border-radius,6px); box-sizing: border-box; color: white; display: block; font-family: Arial, Helvetica, sans-serif; font-size: 10px; font-style: normal; font-weight: 400; height: 383.625px; line-height: 1; outline: 0px; overflow: hidden; padding: 0px; position: relative; vertical-align: top; width: 682px; word-break: initial;" tabindex="-1"><video class="vjs-tech" controls="" data-customhandled="true" data-setup="{ "inactivityTimeout": 0 }" data-t="{"n":"Player","t":61,"a":"click","b":57,"ext":{"videoCs":"BB1jdJ13","videoFormatCode":1006,"title":"Study: Daily fibre supplement improves older adults' brain function","videoDuration":95,"playerInstanceId":"vjs_video_3_html5_api","playType":"pb","playerTech":"HTML5","pluginVersion":"HTML5","size":"0x0","videoPlayerType":"mp4:progressive","playerType":"HTML5","videoUrl":"https://prod-streaming-video-msn-com.akamaized.net/5f74b349-3b3f-45f9-903e-8cf49b2d5ba8/18b7a3fc-fbfe-4aed-afed-fc5e5dbd.ism/manifest(format=m3u8-aapl)"}}" id="vjs_video_3_html5_api" muted="muted" poster="https://www.msn.com/en-us/health/medical/massive-study-pinpoints-specific-gut-bacteria-linked-to-alzheimer-s/ar-AA1hk0io?ocid=msedgdhp&pc=SMTS&cvid=7e44b47a5f06402b84f51ac45a1e823e&ei=76" preload="auto" role="button" style="border-radius: var(--video-border-radius,0); 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display: flex; gap: 10px; justify-content: space-between; list-style-type: none; margin-bottom: 0px; margin-top: 4px; padding: 0px;"><li style="border-radius: 4px; border: 2px solid rgba(255, 255, 255, 0.4); cursor: default; height: 135px; width: 235px;"><a data-t="{"n":"relatedPlayListSlate","t":61,"a":"click","d":"https://www.msn.com/en-us/video/health/%E2%80%98first-step%E2%80%99-using-ai-on-routine-clinical-data-to-identify-alzheimer%E2%80%99s-disease-early/vi-BB1jT6xe?ocid=msedgdhp"}" href="https://www.msn.com/en-us/video/health/%E2%80%98first-step%E2%80%99-using-ai-on-routine-clinical-data-to-identify-alzheimer%E2%80%99s-disease-early/vi-BB1jT6xe?ocid=msedgdhp" role="link" target="_blank"><div class="playlist-thumbnail" style="height: 135px; overflow: hidden; position: relative; width: 204.159px;"><img alt="‘First Step’ Using AI on Routine Clinical Data to Identify Alzheimer’s Disease Early" src="https://img-s-msn-com.akamaized.net/tenant/amp/entityid/BB1jT4BH.img" style="aspect-ratio: 16 / 9; border-radius: 4px; display: block; height: 135px; opacity: 0.9; width: 204.159px;" title="‘First Step’ Using AI on Routine Clinical Data to Identify Alzheimer’s Disease Early" /><div class="thumbnail-overlay" style="backdrop-filter: blur(10px); background: rgba(0, 0, 0, 0.55); color: white; display: flex; flex-direction: column; height: 135px; inset: 0px; opacity: 0; position: absolute; transition: all 0.5s ease 0s; width: 204.159px;"><div class="thumbnail-abstract" style="display: flex; flex-direction: column; margin: 12px; position: absolute; top: 0px;"><span class="thumbnail-abstract-subhead" style="align-items: center; color: white; display: flex; font-size: 12px; font-style: normal; font-weight: 400; line-height: 16px; margin-bottom: 12px; opacity: 0.8;"><img alt="Dailymotion/" src="https://img-s-msn-com.akamaized.net/tenant/amp/entityid/AALnInq.img" style="aspect-ratio: 16 / 9; border-radius: 4px; display: block; height: 16px; left: 0px; margin-right: 6px; opacity: 0.9; top: 0px; width: 16px;" />Dailymotion</span><span class="thumbnail-title" role="heading" style="-webkit-box-orient: vertical; -webkit-line-clamp: 2; color: #fbfbfb; display: -webkit-box; font-size: 14px; font-weight: 600; line-height: 20px; overflow: hidden; text-overflow: ellipsis;">‘First Step’ Using AI on Routine Clinical Data to Identify Alzheimer’s Disease Early</span></div><div class="thumbnail-abstract-timer" style="align-items: center; background: rgba(0, 0, 0, 0.6); border-radius: 4px; bottom: 0px; display: flex; flex-direction: row; font-size: 12px; font-weight: 600; height: 20px; line-height: 16px; margin: 12px; padding: 2px 8px 2px 4px; position: absolute; width: 54px;"><span style="height: 12px; margin: 4px 6px; width: 12px;"><svg fill="none" height="12" viewbox="0 0 12 12" width="12" xmlns="http://www.w3.org/2000/svg"><path d="M6 0C9.31371 0 12 2.68629 12 6C12 9.31371 9.31371 12 6 12C2.68629 12 0 9.31371 0 6C0 2.68629 2.68629 0 6 0ZM6 1C3.23858 1 1 3.23858 1 6C1 8.76142 3.23858 11 6 11C8.76142 11 11 8.76142 11 6C11 3.23858 8.76142 1 6 1ZM5.50153 3C5.74699 3 5.95114 3.17688 5.99347 3.41012L6.00153 3.5V6H7.5C7.77614 6 8 6.22386 8 6.5C8 6.74546 7.82312 6.94961 7.58988 6.99194L7.5 7H5.50153C5.25607 7 5.05192 6.82312 5.00958 6.58988L5.00153 6.5V3.5C5.00153 3.22386 5.22538 3 5.50153 3Z" fill="white"></path></svg></span>1:12</div></div></div></a></li><li style="border-radius: 4px; 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opacity: 0; position: absolute; transition: all 0.5s ease 0s; width: 204.159px;"><div class="thumbnail-abstract" style="display: flex; flex-direction: column; margin: 12px; position: absolute; top: 0px;"><span class="thumbnail-abstract-subhead" style="align-items: center; color: white; display: flex; font-size: 12px; font-style: normal; font-weight: 400; line-height: 16px; margin-bottom: 12px; opacity: 0.8;"><img alt="KRON San Francisco/" src="https://img-s-msn-com.akamaized.net/tenant/amp/entityid/AAKX0Vq.img" style="aspect-ratio: 16 / 9; border-radius: 4px; display: block; height: 16px; left: 0px; margin-right: 6px; opacity: 0.9; top: 0px; width: 16px;" />KRON San Francisco</span><span class="thumbnail-title" role="heading" style="-webkit-box-orient: vertical; -webkit-line-clamp: 2; color: #fbfbfb; display: -webkit-box; font-size: 14px; font-weight: 600; line-height: 20px; overflow: hidden; text-overflow: ellipsis;">Using A.I. to detect early signs of Alzheimer's</span></div><div class="thumbnail-abstract-timer" style="align-items: center; background: rgba(0, 0, 0, 0.6); border-radius: 4px; bottom: 0px; display: flex; flex-direction: row; font-size: 12px; font-weight: 600; height: 20px; line-height: 16px; margin: 12px; padding: 2px 8px 2px 4px; position: absolute; width: 54px;"><span style="height: 12px; margin: 4px 6px; width: 12px;"><svg fill="none" height="12" viewbox="0 0 12 12" width="12" xmlns="http://www.w3.org/2000/svg"><path d="M6 0C9.31371 0 12 2.68629 12 6C12 9.31371 9.31371 12 6 12C2.68629 12 0 9.31371 0 6C0 2.68629 2.68629 0 6 0ZM6 1C3.23858 1 1 3.23858 1 6C1 8.76142 3.23858 11 6 11C8.76142 11 11 8.76142 11 6C11 3.23858 8.76142 1 6 1ZM5.50153 3C5.74699 3 5.95114 3.17688 5.99347 3.41012L6.00153 3.5V6H7.5C7.77614 6 8 6.22386 8 6.5C8 6.74546 7.82312 6.94961 7.58988 6.99194L7.5 7H5.50153C5.25607 7 5.05192 6.82312 5.00958 6.58988L5.00153 6.5V3.5C5.00153 3.22386 5.22538 3 5.50153 3Z" fill="white"></path></svg></span>4:42</div></div></div></a></li><li style="border-radius: 4px; border: 2px solid rgba(255, 255, 255, 0.4); cursor: default; height: 135px; width: 235px;"><a data-t="{"n":"relatedPlayListSlate","t":61,"a":"click","d":"https://www.msn.com/en-us/video/health/5-nutrients-that-might-stop-alzheimer%E2%80%99s-%E2%80%94-and-foods-rich-in-them/vi-BB1jY3M9?ocid=msedgdhp"}" href="https://www.msn.com/en-us/video/health/5-nutrients-that-might-stop-alzheimer%E2%80%99s-%E2%80%94-and-foods-rich-in-them/vi-BB1jY3M9?ocid=msedgdhp" role="link" target="_blank"><div class="playlist-thumbnail" style="height: 135px; overflow: hidden; position: relative; width: 204.159px;"><img alt="5 Nutrients That Might Stop Alzheimer’s — and Foods Rich in Them" src="https://img-s-msn-com.akamaized.net/tenant/amp/entityid/BB1jYhGO.img" style="aspect-ratio: 16 / 9; border-radius: 4px; display: block; height: 135px; opacity: 0.9; width: 204.159px;" title="5 Nutrients That Might Stop Alzheimer’s — and Foods Rich in Them" /><div class="thumbnail-overlay" style="backdrop-filter: blur(10px); background: rgba(0, 0, 0, 0.55); color: white; display: flex; flex-direction: column; height: 135px; inset: 0px; opacity: 0; position: absolute; transition: all 0.5s ease 0s; width: 204.159px;"><div class="thumbnail-abstract" style="display: flex; flex-direction: column; margin: 12px; position: absolute; top: 0px;"><span class="thumbnail-abstract-subhead" style="align-items: center; color: white; display: flex; font-size: 12px; font-style: normal; font-weight: 400; line-height: 16px; margin-bottom: 12px; opacity: 0.8;"><img alt="Money Talks News/" src="https://img-s-msn-com.akamaized.net/tenant/amp/entityid/AA1aNqsY.img" style="aspect-ratio: 16 / 9; border-radius: 4px; display: block; height: 16px; left: 0px; margin-right: 6px; opacity: 0.9; top: 0px; width: 16px;" />Money Talks News</span><span class="thumbnail-title" role="heading" style="-webkit-box-orient: vertical; -webkit-line-clamp: 2; color: #fbfbfb; display: -webkit-box; font-size: 14px; font-weight: 600; line-height: 20px; overflow: hidden; text-overflow: ellipsis;">5 Nutrients That Might Stop Alzheimer’s — and Foods Rich in Them</span></div><div class="thumbnail-abstract-timer" style="align-items: center; background: rgba(0, 0, 0, 0.6); border-radius: 4px; bottom: 0px; display: flex; flex-direction: row; font-size: 12px; font-weight: 600; height: 20px; line-height: 16px; margin: 12px; padding: 2px 8px 2px 4px; position: absolute; width: 54px;"><span style="height: 12px; margin: 4px 6px; width: 12px;"><svg fill="none" height="12" viewbox="0 0 12 12" width="12" xmlns="http://www.w3.org/2000/svg"><path d="M6 0C9.31371 0 12 2.68629 12 6C12 9.31371 9.31371 12 6 12C2.68629 12 0 9.31371 0 6C0 2.68629 2.68629 0 6 0ZM6 1C3.23858 1 1 3.23858 1 6C1 8.76142 3.23858 11 6 11C8.76142 11 11 8.76142 11 6C11 3.23858 8.76142 1 6 1ZM5.50153 3C5.74699 3 5.95114 3.17688 5.99347 3.41012L6.00153 3.5V6H7.5C7.77614 6 8 6.22386 8 6.5C8 6.74546 7.82312 6.94961 7.58988 6.99194L7.5 7H5.50153C5.25607 7 5.05192 6.82312 5.00958 6.58988L5.00153 6.5V3.5C5.00153 3.22386 5.22538 3 5.50153 3Z" fill="white"></path></svg></span>0:57</div></div></div></a></li></ul></div></div></div><div class="video-clear-div" style="clear: both; display: block;"></div></div></div></div><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">That's not to say the balance is always a harmonious one. Shifts in our immune system can give some species an advantage over others. Likewise, changes in the makeup of microbes – by way of<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.sciencealert.com/spicing-up-your-meals-could-be-one-simple-way-to-build-a-healthier-gut" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">shifts in our diet</a>, for example – can profoundly affect the body's functioning. For better and worse.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">The tug-of-war between our microbial census and general health can ripple throughout the body in less than predictable ways, sowing confusion in how<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.sciencealert.com/newly-discovered-gut-microbe-could-be-a-trigger-for-rheumatoid-arthritis" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">distant tissues identify friend and foe</a>.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">In recent years,<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.sciencedirect.com/science/article/abs/pii/S0278584620304280?via%3Dihub" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">researchers have focused on this</a><span> </span>complex diplomacy between gut microflora, the immune system, and neurological functioning in an attempt to understand why areas of the brain degenerate and give rise to the symptoms of memory loss and cognitive decline we recognize as Alzheimer's disease.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">Observational studies revealed a<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.nature.com/articles/s41598-017-13601-y" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">reduction in the diversity of gut microbes</a><span> </span>in individuals diagnosed with the condition,<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.sciencedirect.com/science/article/abs/pii/S0889159108003486?via%3Dihub" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">while laboratory analyses</a><span> </span>showed gut bacteria can release chemicals that could induce damaging inflammatory signals in the brain.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">Complicating matters is a gene involved in the movement of fats through the blood known as<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://en.wikipedia.org/wiki/Apolipoprotein_E" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">apolipoprotein E</a><span> </span>(APOE). Of the three versions found in humans, a variant known as E4 appears to be a<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.sciencealert.com/alzheimers-gene-doesnt-guarantee-dementia-heres-what-you-can-do-to-reduce-risk" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">genetic risk for Alzheimer's</a>. Why this is the case isn't clear, though<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.frontiersin.org/articles/10.3389/fnins.2021.619051/full" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">there's good reason</a><span> </span>to suspect that having at least one copy of APOE E4 might hold some sway over the composition of our microbial citizens.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">This latest exploration of the connections between microbes, APOE E4, and Alzheimer's provides even more compelling evidence of a mechanism at work in the gut.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">The team trawled through detailed records of 119 bacterial genera based on a study involving thousands of participants, known as the<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-018-0479-3" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">MiBioGen Consortium</a>.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">An initial search of bacterial genes that could be associated with Alzheimer's revealed 20 genera suspected of playing some kind of role in the disease's development. A second hunt through a more constrained sample produced a slightly more certain 10 genera – six of which were fewer among diagnosed patients, and the remaining four being more common.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">Of those 10 bacteria genera, four seemed to have a relationship with an APOE allele that is thought to raise the risk of Alzheimer's disease.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">One example genus is the Actinobacterium<span> </span><em>Collinsella</em>, which isn't only associated with Alzheimer's and the APOE variant but rheumatoid arthritis, atherosclerosis, and Type-2<span> </span><a class="lar_link lar_link_outgoing" data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.sciencealert.com/diabetes" rel="nofollow" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">diabetes</a><span> </span>as well.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">The researchers suspect<span> </span><em>Collinsella's</em><span> </span>ability to promote the expression of inflammatory messenger hormones, together with its knack for making the gut more permeable, could play a role in exacerbating – if not triggering – neurological damage.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">Elevated cholesterol and low-density lipoprotein (LDL) levels found in healthy adults with high numbers of<span> </span><em>Collinsella</em><span> </span>further show some link between microbes, fat metabolism, and neurodegeneration.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">This is just one avenue for exploration; the research also uncovered 'protective' bacterial groups that could counter inflammation.</p><div class="intra-article-module" data-t="{"n":"intraArticle","t":13}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; orphans: 2; position: relative; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; width: 682px; word-spacing: 0px; z-index: 97;"></div><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">Alzheimer's disease is the most common form of dementia, which is<span> </span><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(21)00249-8/fulltext" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">projected to affect 150 million people worldwide by the middle of the century</a>, thanks largely to a substantial global population growing older by the year.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">Tracing the origins of the illness and understanding its pathology on a fundamental level is vital if we're to find ways to treat or even prevent its symptoms.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;">This research was published in<span> </span><em><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://www.nature.com/articles/s41598-023-31730-5" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">Scientific Reports</a></em>.</p><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;"><em>A version of this article was first published in April 2023.</em></p></div>oc1deanhttp://www.blogger.com/profile/02302555382262295577noreply@blogger.com0tag:blogger.com,1999:blog-151811238595694978.post-76867239567188542272024-03-17T16:57:00.003-04:002024-03-17T17:05:39.226-04:00Xanthurenic acid: A role in brain intercellular signaling<h3 style="text-align: left;">Ask your competent? doctor how this will help connect up your brain regions again post stroke. </h3><h3 style="text-align: left;">And since your doctor was so competent a decade ago they started working with this since you need neurogenesis to recover from your stroke. Oh, I guess you don't have a functioning stroke doctor, do you? Sucks to be stuck with your doctor then!<br /></h3><h3><a href="http://oc1dean.blogspot.com/2012/05/g-protein-coupled-receptors-in-adult.html"><u>G-Protein-Coupled Receptors in Adult Neurogenesis</u></a> May 2012 </h3><h3 >The latest here:<br /></h3><h3 style="text-align: left;"></h3><h3 style="text-align: left;"><u><a href="https://onlinelibrary.wiley.com/doi/pdf/10.1111/jnc.16099" target="_blank"> Xanthurenic acid: A role in brain intercellular signaling</a></u></h3><div style="text-align: left;">Michel Maitre1 | Omar Taleb1 | Hélène Jeltsch-David1,2 | Christian Klein1 |<br />Ayikoe-Guy Mensah-Nyagan1<br />Abbreviations: 3-HK, 3-hydroxykynurenine; AhR, aryl hydrocarbon receptor; BBB, blood–brain barrier; CNS, central nervous system; CSF, cerebrospinal fluid; DA, dopamine; EPSP,<br />excitatory postsynaptic potential; FICZ, 6-formylindolo-carbazole; GC–MS, gas chromatography–mass spectrometry; GPCR, G-protein-coupled receptor; GTP, guanosine-5′-<br />triphosphate; IDO1, indolamine 2,3 dioxygenase; I.P., intra-peritoneal; KAT, kynurenine aminotransferase; KMO, kynurenine monooxygenase; KP, kynurenine pathway; KYNA,<br />kynurenic acid; LATS, large neutral amino acid transporters; NAAG, N-Acetyl-Aspartyl- Glutamate; NADP, nicotinamide adenine dinucleotide phosphate; NADPH, nicotinamide adenine<br />dinucleotide phosphate hydrogen; NMDA, N-methyl-d-aspartate; OAT, organic anion transporter; PFC, prefrontal cortex; QUIN, quinolinic acid; ROS, reactive oxygen species; SN,<br />substantia nigra; TDO, tryptophan 2,3 dioxygenase; TH, tyrosine hydroxylase; Trp, tryptophan; TTX, tetrodotoxin; VTA, ventral tegmental area; XA, xanthurenic acid.<br />1<br />Biopathologie de la Myéline,<br />Neuroprotection et Stratégies<br />Thérapeutiques, INSERM U1119,<br />Fédération de Médecine Translationnelle<br />de Strasbourg (FMTS), Université de<br />Strasbourg, Bâtiment CRBS de la Faculté<br />de Médecine, Strasbourg, France<br />2 Biotechnologie et signalisation cellulaire,<br />UMR 7242 CNRS/Université de<br />Strasbourg, Illkirch Cedex, France<br />Correspondence<br />Michel Maitre, Biopathologie de la<br />Myéline, Neuroprotection et Stratégies<br />Thérapeutiques, INSERM U1119,<br />Fédération de Médecine Translationnelle<br />de Strasbourg (FMTS), Université de<br />Strasbourg, Bâtiment CRBS de la Faculté<br />de Médecine, 1 rue Eugène Boeckel,<br />67000 Strasbourg, France.<br />Email: maitre@unistra.fr<br /><h3 style="text-align: left;">Abstract</h3>Xanthurenic acid (XA) raises a growing multidisciplinary interest based upon its oxi-<br />dizing properties, its ability to complex certain metal ions, and its detoxifier capac-<br />ity of 3-hydroxykynurenine (3-HK), its brain precursor. However, little is still known<br />about the role and mechanisms of action of XA in the central nervous system (CNS).<br />Therefore, many research groups have recently investigated XA and its central func-<br />tions extensively. The present paper critically reviews and discusses all major data re-<br />lated to XA properties and neuronal activities to contribute to the improvement of the<br />current knowledge on XA's central roles and mechanisms of action.<b><span style="color: #ff00fe;"> In particular, our<br />data showed the existence of a specific G-protein-coupled receptor (GPCR) for XA<br />localized exclusively in brain neurons exhibiting Ca 2+-dependent dendritic release and<br />specific electrophysiological responses. XA properties and central activities suggest a<br />role for this compound in brain intercellular signaling.</span></b> Indeed, XA stimulates cerebral<br />dopamine (DA) release contrary to its structural analog, kynurenic acid (KYNA). Thus,<br />KYNA/XA ratio could be fundamental in the regulation of brain glutamate and DA<br />release. Cerebral XA may also represent an homeostatic signal between the periphery<br />and several brain regions where XA accumulates easily after peripheral administra-<br />tion. Therefore, XA status in certain psychoses or neurodegenerative diseases seems<br />to be reinforced by its brain-specific properties in balance with its formation and pe-<br />ripheral inputs.<br /></div>oc1deanhttp://www.blogger.com/profile/02302555382262295577noreply@blogger.com0tag:blogger.com,1999:blog-151811238595694978.post-87906930068336168022024-03-17T16:30:00.000-04:002024-03-17T16:30:14.663-04:00Study links certain fatty acids in blood to decreased Alzheimer’s risk<h3 style="text-align: left;">You can ask your competent? doctor what should done with this research to vastly reduce your chances of dementia.</h3><h3 style="text-align: left;">Your risk of dementia, has your doctor
told you of this? <span style="color: red;"><span style="font-size: large;">Your doctor is responsible for preventing this! </span></span></h3><h3 style="text-align: left;">
<b>1.</b> A documented <a href="http://oc1dean.blogspot.com/2013/05/search-for-link-between-strokes-and.html" style="color: #2288bb; text-decoration: none;" target="_blank"><span style="color: #993333;"><u>33% dementia chance post-stroke from an Australian study?</u></span></a> <b>May 2012.</b></h3>
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<b>2.</b> Then this study came out and seems to have a <a href="http://oc1dean.blogspot.com/2014/05/current-perspectives-in-post-stroke.html" style="color: #2288bb; text-decoration: none;" target="_blank"><u>range from 17-66%</u></a>. <b>December 2013.`<span> </span></b></h3>
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<b>3.</b> A <a href="http://oc1dean.blogspot.com/2013/07/the-determinants-of-dementia-after.html" style="color: #2288bb; text-decoration: none;" target="_blank"><u>20% chance in this research.</u></a> <b>July 2013.</b></h3>
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<b>4. </b><a href="http://oc1dean.blogspot.com/2018/09/dementia-risk-doubled-in-patients.html" style="color: #2288bb; text-decoration: none;"><u>Dementia Risk Doubled in Patients Following Stroke</u></a> September 2018 </h3><h3 style="text-align: left;"></h3><h3><u><a href="https://www.msn.com/en-us/health/other/study-links-certain-fatty-acids-in-blood-to-decreased-alzheimer-s-risk/ar-AA1my2OB?ocid=msedgdhp&pc=SMTS&cvid=7e44b47a5f06402b84f51ac45a1e823e&ei=44" target="_blank">Study links certain fatty acids in blood to decreased Alzheimer’s risk</a></u></h3><div style="text-align: left;"><p data-t="{"n":"blueLinks"}" style="-webkit-text-stroke-width: 0px; background-color: white; color: #2b2b2b; font-family: "Segoe UI", "Segoe UI Midlevel", sans-serif; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: normal; margin: 0px 0px 16px; orphans: 2; text-align: start; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;"><span class="dropcap-element-slot" style="float: left; font-family: "Eb Garamond"; font-size: 64px; font-style: normal; line-height: 52px; margin-inline-end: 8px;">I</span>n a significant stride towards understanding Alzheimer’s disease, researchers have discovered that higher levels of certain fatty acids in the blood are associated with a lower risk of brain changes typical of the disease. This finding, published in<span> </span><i><a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://doi.org/10.1093/gerona/glad248" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank">The Journals of Gerontology: Series A</a></i>, could pave the way for more effective early detection and management strategies for Alzheimer’s, a condition that affects millions worldwide.</p>Alzheimer’s disease is a progressive neurological disorder that primarily affects older adults, leading to memory loss, impaired reasoning, and changes in personality and behavior. It is the most common form of dementia, characterized by the accumulation of amyloid-beta proteins in the brain, forming plaques that disrupt cell function. Despite extensive research, Alzheimer’s remains incurable, and its exact cause is still not fully understood, making early detection and management strategies critical.“The incidence of dementia is increasing over time, impacting the persons affected, as well as their families and loved ones,” said study author Natasha A. Grande de França. “An earlier and more accurate diagnosis can help to prolong the quality of life; however, the diagnosis of dementia is still plenty biased and hard to do. For this reason, we were interested in finding blood biomarkers that could be used to help clinicians in the diagnosis of dementia, especially Alzheimer’s disease (the most common dementia).”concerns just overwhelming. Feelings it was It was hard to To carry out the study, the researchers employed a cross-sectional design, utilizing baseline measurements from a larger ongoing study named COGFRAIL. This study involved 317 older adults, aged 70 and above, who exhibited mild cognitive impairment but not severe dementia. The participants were chosen based on specific cognitive scores and were either prefrail or frail, meaning they showed signs of physical decline but were not entirely dependent on others for daily living. The study excluded individuals with severe psychological conditions or high dependency on others for basic activities. The final sample included a total of 177 individuals. França and her colleagues employed several measures to gather data. They used positron emission tomography (PET) scans to measure the levels of amyloid-beta, a protein that forms clumps in the brains of people with Alzheimer’s, in various brain regions. Blood samples were also collected and analyzed for various nutrients, including different types of fatty acids, vitamins, and an amino acid called homocysteine. The analysis of fatty acids was particularly comprehensive, examining their composition in red blood cell membranes. Over half of the participants (57.6%) were identified as having high amyloid-beta levels in their brains. <b><span style="color: #ff00fe;">The researchers found that higher concentrations of a fatty acid called clupanodonic acid were consistently associated with lower amyloid-beta load in the brain.</span></b> This association was observed in almost all regions of the brain, except for the thalamus. “I was expecting that if any association would be significant, that would arise from the fatty acids omega-3 EPA and DHA,” França told PsyPost. “However, a more consistent result was observed with a metabolite of EPA, the clupanodonic acid. This suggests we should expand the look and the research to less well-known fatty acids, in particular the metabolites of the EPA and DHA as potential more precise biomarkers.” Furthermore, the study noted that linoleic acid showed a positive association with amyloid-beta load, while mead acid and adrenic acid were negatively associated, though less consistently than clupanodonic acid. Interestingly, the study did not find any significant associations between amyloid-beta load and blood vitamins or homocysteine, a common amino acid in the blood.“Our study found potential blood biomarkers to be used in the diagnosis of dementias associated with the aggregation of amyloid-beta in the brain – a peptide associated with the development of Alzheimer’s disease,” França told PsyPost. “However, this is just the first step that needs to be confirmed with other studies in other populations.” Like all scientific research, this study comes with its limitations. The cross-sectional nature of the research means that it can’t definitively establish cause and effect. Additionally, the sample consisted of older adults who were either prefrail or frail, which may not represent the broader population. “Our study has a cross-sectional design and was conducted with a very specific population (older adults with a light degree of cognitive impairment and who were at least pre-frail). So, some questions I can list include: has the association between clupanodonic acid and amyloid-beta happened by chance? Is this association true in populations in different conditions? What is the timing? – when does it start and when does it finish?” França explained. The study, “<a data-t="{"n":"destination","t":13,"b":1,"c.t":7}" href="https://academic.oup.com/biomedgerontology/article-abstract/79/1/glad248/7330065" style="color: var(--accent-foreground-rest); text-decoration: none;" target="_blank"><u>Associations Between Blood Nutritional Biomarkers and Cerebral Amyloid-β: Insights From the COGFRAIL Cohort Study</u></a>“, was authored by Natasha A. Grande de França, Gustavo Díaz, Laetitia Lengelé, Gaëlle Soriano, Sylvie Caspar-Bauguil, Laure Saint-Aubert, Pierre Payoux, Laure Rouch, Bruno Vellas, Philipe de Souto Barreto, and Sandrine Sourdet.</div>oc1deanhttp://www.blogger.com/profile/02302555382262295577noreply@blogger.com0tag:blogger.com,1999:blog-151811238595694978.post-21961659562473381972024-03-17T16:10:00.004-04:002024-03-17T16:10:53.584-04:00Primary Motor Cortex in Stroke: A Functional MRI-Guided Proton MR Spectroscopic Study<h3 style="text-align: left;"> I don't see how anything here helps survivors get recovered! You're fired!<br /></h3><h3 id="swp-tcr--title" style="text-align: left;"><u><a href="https://www.academia.edu/45372891/Primary_Motor_Cortex_in_Stroke_A_Functional_MRI_Guided_Proton_MR_Spectroscopic_Study?email_work_card=title" target="_blank">Primary Motor Cortex in Stroke: A Functional MRI-Guided Proton MR Spectroscopic Study</a></u></h3><div id="swp-tcr--title" style="text-align: left;"> Carmen M. Cirstea, MD, PhD; William M. Brooks, PhD; Sorin C. Craciunas, MD;Elena A. Popescu, PhD; In-Young Choi, PhD; Phil Lee, PhD; Ali Bani-Ahmed, BSc;Hung-Wen Yeh, PhD; Cary R. Savage, PhD; Leonardo G. Cohen, MD; Randolph J. Nudo, PhD<br /><b> Background and Purpose</b></div><div id="swp-tcr--title" style="text-align: left;"><b> </b></div><div id="swp-tcr--title" style="text-align: left;"><b> </b>Our goal was to investigate whether certain metabolites, specific to neurons, glial cells, or theneuronal–glial neurotransmission system, in primary motor cortices (M1), are altered and correlated with clinical motor severity in chronic stroke.<br /><b> </b></div><div id="swp-tcr--title" style="text-align: left;"><b>Methods</b></div><div id="swp-tcr--title" style="text-align: left;"><b> </b></div><div id="swp-tcr--title" style="text-align: left;"><b> </b>Fourteen survivors of a single ischemic stroke located outside the M1 and 14 age-matched healthy control subjects were included. At>6 months after stroke, N-acetylaspartate,<br /> myoinositol, and glutamate/glutamine were measured using proton magnetic resonance spectroscopic imaging (in-plane resolution=5x5 mm<sup>2</sup>) in radiologically normal appearing gray matter of the hand representation area, identified by functional MRI, in each M1. Metabolite concentrations and analyses of metabolite correlations within M1 were determined. Relationships between metabolite concentrations and arm motor impairment were also evaluated.<br /><b> Results </b></div><div id="swp-tcr--title" style="text-align: left;"> </div><div id="swp-tcr--title" style="text-align: left;">The stroke survivors showed lower N-acetylaspartate and higher<br /> myoinositol across ipsilesional and contralesional M1 compared with control subjects. Significant correlations between N-acetylaspartate and glutamate/glutamine were found in either M1. Ipsilesional N-acetylaspartate and glutamate/glutamine were positively correlated with arm motor impairment and contralesional N-acetylaspartate with time after stroke.<br /><b>Conclusions</b><br /> </div><div id="swp-tcr--title" style="text-align: left;">Our preliminary data demonstrated significant alterations of neuronal glial interactions in spared M1with the ipsilesional alterations related to stroke severity and contralesional alterations to stroke duration. Thus,MR spectroscopy might be a sensitive method to quantify relevant metabolite changes after stroke and consequently increase our knowledge of the factors leading from these changes in spared motor cortex to motor impairment after stroke.<br /> (Stroke. 2011;42:1004-1009.)<br /><br /></div>oc1deanhttp://www.blogger.com/profile/02302555382262295577noreply@blogger.com0tag:blogger.com,1999:blog-151811238595694978.post-46883507410325436122024-03-16T17:58:00.000-04:002024-03-16T17:58:17.936-04:00Blocking a Single Protein Could Prevent Nerve Damage Responsible For Alzheimer's<h3 style="text-align: left;"> With your elevated risk of dementia, you do expect your competent? doctor and hospital to ensure that human testing gets done? Or will you let incompetence continue to rage on?</h3><h3 style="text-align: left;">Your risk of dementia, has your doctor
told you of this? <span style="color: red;"><span style="font-size: large;">Your doctor is responsible for preventing this! </span></span></h3><h3 style="text-align: left;">
<b>1.</b> A documented <a href="http://oc1dean.blogspot.com/2013/05/search-for-link-between-strokes-and.html" style="color: #2288bb; text-decoration: none;" target="_blank"><span style="color: #993333;"><u>33% dementia chance post-stroke from an Australian study?</u></span></a> <b>May 2012.</b></h3>
<h3 style="text-align: left;">
</h3>
<h3 style="text-align: left;">
<b>2.</b> Then this study came out and seems to have a <a href="http://oc1dean.blogspot.com/2014/05/current-perspectives-in-post-stroke.html" style="color: #2288bb; text-decoration: none;" target="_blank"><u>range from 17-66%</u></a>. <b>December 2013.`<span> </span></b></h3>
<h3 style="text-align: left;">
</h3>
<h3 style="text-align: left;">
<b>3.</b> A <a href="http://oc1dean.blogspot.com/2013/07/the-determinants-of-dementia-after.html" style="color: #2288bb; text-decoration: none;" target="_blank"><u>20% chance in this research.</u></a> <b>July 2013.</b></h3>
<h3 style="text-align: left;">
</h3>
<h3 style="text-align: left;">
<b>4. </b><a href="http://oc1dean.blogspot.com/2018/09/dementia-risk-doubled-in-patients.html" style="color: #2288bb; text-decoration: none;"><u>Dementia Risk Doubled in Patients Following Stroke</u></a> September 2018 </h3><h3 style="text-align: left;"></h3><h3><u><a href="https://www.msn.com/en-us/health/other/blocking-a-single-protein-could-prevent-nerve-damage-responsible-for-alzheimer-s/ar-BB1jvVJ5?ocid=msedgdhp&pc=SMTS&cvid=7e44b47a5f06402b84f51ac45a1e823e&ei=10" target="_blank">Blocking a Single Protein Could Prevent Nerve Damage Responsible For Alzheimer's</a></u></h3>Scientists have identified a key protein in the development of Alzheimer's disease which could prove critical in slowing or even halting the condition's progress. In tests on <b><span style="color: #ff00fe;">mice</span></b>, a research team led by University of Colorado pharmacologist Tyler Martinez found that blocking a protein called murine double-minute 2 (Mdm2) stopped the destruction of the protrusions or 'junctions (synapses)<span> </span>that aid communication between brain cells. This degeneration is triggered by the build-up of a substance called amyloid-beta, which has long been linked to clogging up the brain in people with Alzheimer's. When Mdm2 was deactivated, amyloid-beta no longer had the same effect. "When this protein Mdm2 is turned on inappropriately, it leads to pruning of the synapses when amyloid-beta is present,"says<span> </span>neuroscientist Mark Dell'Acqua, from the University of Colorado."When we used the drug that inhibits Mdm2 on the neurons, it completely blocked dendritic spine loss triggered by amyloid-beta. So inhibiting this protein is clearly working." While a certain quantity of amyloid-beta and the trimming of dendritic spines serve important functions in a healthy body, problems happen when they get out of control. Understanding the first links in that chain is likely to be crucial in understanding Alzheimer's. The neurological communications handled by dendritic spines and synapses are crucial in our ability to learn and remember – and in Alzheimer's, those functions are significantly impaired, due to the breakdown in the brain's signaling, <b><span style="color: #ff00fe;">cancer drug nutlin was used to limit Mdm2 activity</span></b>, which itself usually plays a significant role in tumor suppression.<span> </span><span>It's still early days for this particular area of research, but what the researchers have seen in mouse brains looks promising.</span> "This is an encouraging first step that gives us a new lead to pursue," says Dell'Acqua. The next stage would be to see if the effects of inhibiting Mdm2 really do slow Alzheimer's down. It's a complex and multi-faceted disease, and while amyloid-beta proteins are chief suspects in the hunt for a cause, there's<span> </span> not enough evidence yet for a conviction. Researchers continue to make new discoveries about how Alzheimer's gets started and goes on to impact the brain, and it's possible that the rest of the body is involved too – something that the team behind this latest study is ready to acknowledge. "There are questions if anti-amyloid therapy is the be-all and end-all of Alzheimer's disease therapy," says Dell'Acqua. "Even if you could tolerate the high cost, the effectiveness is questionable." "We are saying that it may also be possible to intervene in the process by blocking some of the impacts of amyloid-b. And you could intervene by targeting Mdm2." The research has been published in eNeuro.oc1deanhttp://www.blogger.com/profile/02302555382262295577noreply@blogger.com0tag:blogger.com,1999:blog-151811238595694978.post-64630835547656180222024-03-16T17:30:00.000-04:002024-03-16T17:30:22.577-04:00Heart attack and stroke survivors face barriers to get healthier - Canada<h3 style="text-align: left;"><span style="color: red;"><span style="font-size: x-large;">The absolute worst barrier for stroke recovery is the COMPLETE FAILURE OF YOUR STROKE MEDICAL 'PROFESSIONALS' to solve stroke to 100% recovery! </span></span></h3><h3 style="text-align: left;">You don't understand <span style="color: red;">ONE GODDAMN THING ABOUT SURVIVOR MOTIVATION, DO YOU?</span>
You create 100% recovery protocols and your survivor will be motivated
to do the millions of reps needed because they are looking forward to
100% recovery. <span style="color: red;"><span style="font-size: x-large;">GET THERE!</span><span style="font-size: medium;"> </span></span></h3><h3 style="text-align: left;">The problem is stroke researchers are not motivated to solve stroke. What the fuck is your solution to that failure? <span style="color: red;">We still don't know how to motivate stroke medical 'professionals' to solve stroke to 100% recovery! </span></h3><h3 style="text-align: left;"><span style="color: red;"><span style="font-size: x-large;"> </span></span></h3><h3 data-test-locator="headline" id="caas-lead-header-59ecf993-d81e-3216-b940-bfa737a573e0" style="text-align: left;"><u><a href="https://ca.movies.yahoo.com/movies/news/heart-attack-stroke-survivors-face-barriers-healthier-040130130.html" target="_blank">Heart attack and stroke survivors face barriers to get healthier - Canada</a></u></h3><div data-test-locator="headline" id="caas-lead-header-59ecf993-d81e-3216-b940-bfa737a573e0" style="text-align: left;"><div class="caas-inner-body"><div class="caas-body"><p>Some survivors of
a heart attack or stroke struggle to get moving, manage stress and
maintain a healthy weight, says a new Canadian report that stresses how
important rehabilitation programs and family support can be.</p><p>About
165,000 Canadians survived a heart attack or stroke last year, but
there are still 350,000 hospitalizations for the diseases each year, the
Heart and Stroke Foundation said in its report released Monday.</p><p>The
report includes highlights of an online poll of 2,010 Canadians who’d
survived a heart attack or stroke, or were the loved ones of survivors.
About seven in 10 survivors said they’d made healthy changes since the
scare.</p><div class="caas-da"><div id="sda-INARTICLE"></div></div><p>Survivors were most successful in eating a healthier diet, quitting smoking and reducing alcohol consumption.</p><p>But among people who needed to make those changes, more than half couldn’t maintain the change and others didn’t try.</p><p>"The
biggest barrier was related to <b><span style="color: #ff00fe;">motivation</span></b>, which was defined as a lack
of interest in making the change, a feeling that the goals were
unrealistic and that there was too much required all at once," the
report’s authors said.</p><p>Other barriers included not understanding
what changes were needed or how to make them, loss of physical or
cognitive abilities since the event, and cost and time constraints.</p><p>The
report’s authors also looked at how to support recovery, calling
rehabilitation referral rates "unacceptably low." Evidence shows that
about one-third of cardiac survivors who are eligible for rehabilitation
are referred.</p><p>The main reason people gave for not starting or
completing rehabilitation as recommended was, "I just didn’t want to do
it," which can be an indicator of other factors such as anxiety,
depression and lack of a clear endorsement from their doctor on the
benefits.</p><p>"The number 1 benefit of rehabilitation is that it keeps
survivors surviving," Dr. Neville Suskin, medical director of cardiac
rehabilitation and secondary prevention at St. Joseph's Health Care in
London, Ont., said in a release. Suskin pointed to other benefits: it
makes people feel better, improves their quality of life, and reduces
hospital readmissions as well as costs to the health-care system.</p><p>More
than eight in 10 survivors said they feel that their family support
helped them achieve a healthy lifestyle, such as assisting with chores
during recovery and keeping stress levels in check.</p><p>The poll was conducted online by Environics Research Group between Nov. 25 and Dec. 3, 2013.</p></div></div></div>oc1deanhttp://www.blogger.com/profile/02302555382262295577noreply@blogger.com0tag:blogger.com,1999:blog-151811238595694978.post-28765864451760935542024-03-16T15:56:00.000-04:002024-03-16T15:56:23.909-04:00Extended reality to assess post-stroke manual dexterity: contrasts between the classic box and block test, immersive virtual reality with controllers, with hand-tracking, and mixed-reality tests<h3 style="text-align: left;">I consider assessments absolutely worthless <span style="color: red;">unless they point DIRECTLY TO 100% RECOVERY PROTOCOLS!</span><br /></h3><h3 class="c-article-title" data-article-title="" data-test="article-title" style="text-align: left;"><a href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x" target="_blank"><u>Extended
reality to assess post-stroke manual dexterity: contrasts between the
classic box and block test, immersive virtual reality with controllers,
with hand-tracking, and mixed-reality tests</u></a></h3><div class="c-article-title" data-article-title="" data-test="article-title" style="text-align: left;"><h1 class="c-article-title" data-article-title="" data-test="article-title"></h1>
<ul class="c-article-author-list c-article-author-list--short js-no-scroll" data-component-authors-activator="authors-list" data-test="authors-list"><li class="c-article-author-list__item"><a data-author-popup="auth-Gauthier-Everard-Aff1-Aff2-Aff3" data-author-search="Everard, Gauthier" data-test="author-name" data-track-action="open author" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#auth-Gauthier-Everard-Aff1-Aff2-Aff3">Gauthier Everard</a>, </li><li class="c-article-author-list__item"><a data-author-popup="auth-Quentin-Burton-Aff3" data-author-search="Burton, Quentin" data-test="author-name" data-track-action="open author" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#auth-Quentin-Burton-Aff3">Quentin Burton</a>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-author-popup="auth-Vincent-Sype-Aff4" data-author-search="Van de Sype, Vincent" data-test="author-name" data-track-action="open author" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#auth-Vincent-Sype-Aff4">Vincent Van de Sype</a>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-author-popup="auth-Th_r_se_Ntabuhashe-Bibentyo-Aff5" data-author-search="Bibentyo, Thérèse Ntabuhashe" data-test="author-name" data-track-action="open author" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#auth-Th_r_se_Ntabuhashe-Bibentyo-Aff5">Thérèse Ntabuhashe Bibentyo</a>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-author-popup="auth-Edouard-Auvinet-Aff5" data-author-search="Auvinet, Edouard" data-test="author-name" data-track-action="open author" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#auth-Edouard-Auvinet-Aff5">Edouard Auvinet</a>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-author-popup="auth-Martin_Gareth-Edwards-Aff6-Aff7" data-author-search="Edwards, Martin Gareth" data-test="author-name" data-track-action="open author" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#auth-Martin_Gareth-Edwards-Aff6-Aff7">Martin Gareth Edwards</a>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-author-popup="auth-Charles_Sebiyo-Batcho-Aff1-Aff2" data-author-search="Batcho, Charles Sebiyo" data-test="author-name" data-track-action="open author" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#auth-Charles_Sebiyo-Batcho-Aff1-Aff2">Charles Sebiyo Batcho</a> & </li><li class="c-article-author-list__item"><a data-author-popup="auth-Thierry-Lejeune-Aff3-Aff4-Aff7" data-author-search="Lejeune, Thierry" data-corresp-id="c1" data-test="author-name" data-track-action="open author" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#auth-Thierry-Lejeune-Aff3-Aff4-Aff7">Thierry Lejeune<svg aria-hidden="true" class="u-icon" height="16" width="16"><use></use></svg></a> </li></ul>
<p class="c-article-info-details" data-container-section="info">
<a data-test="journal-link" data-track-action="journal homepage" data-track-category="article body" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/"><i data-test="journal-title">Journal of NeuroEngineering and Rehabilitation</i></a>
<b data-test="journal-volume"><span class="u-visually-hidden">volume</span> 21</b>, Article number: <span data-test="article-number">36</span> (<span data-test="article-publication-year">2024</span>)
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<section aria-labelledby="Abs1" data-title="Abstract" lang="en"><div class="c-article-section" id="Abs1-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="Abs1">Abstract</h2><div class="c-article-section__content" id="Abs1-content"><h3 class="c-article__sub-heading" data-test="abstract-sub-heading">Background</h3><p>Recent
technological advancements present promising opportunities to enhance
the frequency and objectivity of functional assessments, aligning with
recent stroke rehabilitation guidelines. Within this framework, we
designed and adapted different manual dexterity tests in extended
reality (XR), using immersive virtual reality (VR) with controllers
(BBT-VR-C), immersive VR with hand-tracking (BBT-VR-HT), and
mixed-reality (MD-MR).</p><h3 class="c-article__sub-heading" data-test="abstract-sub-heading">Objective</h3><p>This
study primarily aimed to assess and compare the validity of the
BBT-VR-C, BBT-VR-HT and MD-MR to assess post-stroke manual dexterity.
Secondary objectives were to evaluate reliability, usability and to
define arm kinematics measures.</p><h3 class="c-article__sub-heading" data-test="abstract-sub-heading">Methods</h3><p>A
sample of 21 healthy control participants (HCP) and 21 stroke
individuals with hemiparesis (IHP) completed three trials of the
traditional BBT, the BBT-VR-C, BBT-VR-HT and MD-MR. Content validity of
the different tests were evaluated by asking five healthcare
professionals to rate the difficulty of performing each test in
comparison to the traditional BBT. Convergent validity was evaluated
through correlations between the scores of the traditional BBT and the
XR tests. Test-retest reliability was assessed through correlations
between the second and third trial and usability was assessed using the
System Usability Scale (SUS). Lastly, upper limb movement smoothness
(SPARC) was compared between IHP and HCP for both BBT-VR test versions.</p><h3 class="c-article__sub-heading" data-test="abstract-sub-heading">Results</h3><p>For
content validity, healthcare professionals rated the BBT-VR-HT (0[0–1])
and BBT-MR (0[0–1]) as equally difficult to the traditional BBT,
whereas they rated BBT-VR-C as more difficult than the traditional BBT
(1[0–2]). For IHP convergent validity, the Pearson tests demonstrated
larger correlations between the scores of BBT and BBT-VR-HT (<i>r</i> = 0.94;<i>p</i> < 0.001), and BBT and MD-MR (<i>r</i> = 0.95;<i>p</i> < 0.001) than BBT and BBT-VR-C (<i>r</i> = 0.65;<i>p</i> = 0.001).
BBT-VR-HT and MD-MR usability were both rated as excellent, with median
SUS scores of 83[57.5–91.3] and 83[53.8–92.5] respectively. Excellent
reliability was found for the BBT-VR-C (ICC = 0.96;<i>p</i> < 0.001), BBT-VR-HT (ICC = 0.96;<i>p</i> < 0.001) and BBT-MR (ICC = 0.99;<i>p</i> < 0.001).
The usability of the BBT-VR-C was rated as good with a median SUS of
70[43.8–83.8]. Upper limb movements of HCP were significantly smoother
than for IHP when completing either the BBT-VR-C (t = 2.05;<i>p</i> = 0.043) and the BBT-VR-HT (t = 5.21;<i>p</i> < 0.001).</p><h3 class="c-article__sub-heading" data-test="abstract-sub-heading">Conclusion</h3><p>The different XR manual tests are valid, short-term reliable and usable tools to assess post-stroke manual dexterity.</p><h3 class="c-article__sub-heading" data-test="abstract-sub-heading">Trial registration</h3><p><a href="https://clinicaltrials.gov/ct2/show/NCT04694833">https://clinicaltrials.gov/ct2/show/NCT04694833</a>; Unique identifier: NCT04694833, Date of registration: 11/24/2020.</p></div></div></section>
<section data-title="Background"><div class="c-article-section" id="Sec1-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="Sec1">Background</h2><div class="c-article-section__content" id="Sec1-content"><p>Upper limb impairments are prevalent during both the acute [<a aria-label="Reference 1" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR1" id="ref-link-section-d119306661e647" title="Sunderland A, Bowers MP, Sluman SM, Wilcock DJ, Ardron ME. Impaired dexterity of the ipsilateral hand after stroke and the relationship to cognitive deficit. Stroke. 1999;30(5):949–55.">1</a>, <a aria-label="Reference 2" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR2" id="ref-link-section-d119306661e650" title="Carey LM, Matyas TA. Frequency of discriminative sensory loss in the hand after stroke in a rehabilitation setting. J Rehabil Med. 2011;43(3):257–63.">2</a>] and chronic phase [<a aria-label="Reference 3" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR3" id="ref-link-section-d119306661e653" title="Bowden JL, Lin GG, McNulty PA. The prevalence and magnitude of impaired cutaneous sensation across the hand in the chronic period post-stroke. PLoS ONE. 2014;9(8):e104153.">3</a>]
after a stroke. Such impairments result in activity limitations and
participation restrictions, leading to a decline in the overall quality
of life [<a aria-label="Reference 4" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR4" id="ref-link-section-d119306661e656" title="Meyer S, Karttunen AH, Thijs V, Feys H, Verheyden G. How do somatosensory deficits in the arm and hand relate to upper limb impairment, activity, and participation problems after stroke? A systematic review. Phys Ther. 2014;94(9):1220–31.">4</a>, <a aria-label="Reference 5" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR5" id="ref-link-section-d119306661e659" title="Morris JH, van Wijck F, Joice S, Donaghy M. Predicting health related quality of life 6 months after stroke: the role of anxiety and upper limb dysfunction. Disabil Rehabil. 2013;35(4):291–9.">5</a>].
In the field of neurorehabilitation, regular and time-bounded
assessments of impairments and activity limitations are of utmost
importance for establishing an effective rehabilitation plan [<a aria-label="Reference 6" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR6" id="ref-link-section-d119306661e663" title="Kwakkel G, Lannin NA, Borschmann K, English C, Ali M, Churilov L, et al. Standardized measurement of Sensorimotor Recovery in Stroke trials: Consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable. Neurorehabil Neural Repair. 2017;31(9):784–92.">6</a>, <a aria-label="Reference 7" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR7" id="ref-link-section-d119306661e666" title="Winstein CJ, Stein J, Arena R, Bates B, Cherney LR, Cramer SC, et al. Guidelines for adult Stroke Rehabilitation and Recovery: a Guideline for Healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2016;47(6):e98–169.">7</a>]. Moreover, functional assessments play a critical role in identifying prognostic factors that influence stroke recovery [<a aria-label="Reference 8" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR8" id="ref-link-section-d119306661e669" title="van der Vliet R, Selles RW, Andrinopoulou ER, Nijland R, Ribbers GM, Frens MA, et al. Predicting Upper Limb Motor Impairment Recovery after Stroke: a mixture model. Ann Neurol. 2020;87(3):383–93.">8</a>]. Recently, experts have formulated recommendations for the clinical evaluation of the upper limb in neurorehabilitation [<a aria-label="Reference 9" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR9" id="ref-link-section-d119306661e672" title="Prange-Lasonder GB, Alt Murphy M, Lamers I, Hughes AM, Buurke JH, Feys P, et al. European evidence-based recommendations for clinical assessment of upper limb in neurorehabilitation (CAULIN): data synthesis from systematic reviews, clinical practice guidelines and expert consensus. J Neuroeng Rehabil. 2021;18(1):162.">9</a>]. One such recommended assessment is the Box and Block Test (BBT) [<a aria-label="Reference 10" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR10" id="ref-link-section-d119306661e675" title="Mathiowetz V, Volland G, Kashman N, Weber K. Adult norms for the Box and Block Test of manual dexterity. Am J Occup Ther. 1985;39(6):386–91.">10</a>],
which measures manual dexterity in the activity domain (according to
the International Classification of Functioning, Disability and Health) [<a aria-label="Reference 10" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR10" id="ref-link-section-d119306661e678" title="Mathiowetz V, Volland G, Kashman N, Weber K. Adult norms for the Box and Block Test of manual dexterity. Am J Occup Ther. 1985;39(6):386–91.">10</a>].
Additionally, experts have highlighted the significance of kinematics
in assessing body functions, through measures of movement quality and
compensations during activity of daily living tasks [<a aria-label="Reference 11" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR11" id="ref-link-section-d119306661e682" title="Kwakkel G, Van Wegen E, Burridge JH, Winstein CJ, van Dokkum L, Alt Murphy M, et al. Standardized measurement of quality of upper limb movement after stroke: Consensus-based core recommendations from the second stroke recovery and Rehabilitation Roundtable. Int J Stroke. 2019;14(8):783–91.">11</a>].</p><p>In
recent years, extended reality (XR) has emerged as an innovative and
promising approach in rehabilitation. XR is a comprehensive concept that
encompasses both present and forthcoming advancements in virtual
reality (VR) and mixed reality (MR) [<a aria-label="Reference 12" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR12" id="ref-link-section-d119306661e688" title="Logeswaran A, Munsch C, Chong YJ, Ralph N, McCrossnan J. The role of extended reality technology in healthcare education: towards a learner-centred approach. Future Healthc J. 2021;8(1):e79–84.">12</a>].
VR technology allows for a computerized immersion of individuals in
digitally created worlds, enabling them to experience multiple sensory
stimuli and interact with the virtual environment through various
modalities [<a aria-label="Reference 13" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR13" id="ref-link-section-d119306661e691" title="Saposnik G, Levin M. Virtual reality in stroke rehabilitation: a meta-analysis and implications for clinicians. Stroke. 2011;42(5):1380–6.">13</a>].
There are two primary types of VR experiences: non-immersive VR, where
users remain aware of their physical surroundings and receive visual
feedback through a 2D display, and immersive VR (iVR), which allows
complete submersion in the virtual environment (using a Head Mounted
Display (HMD) or a large curved screen with panoramic view) and provides
a panoramic view [<a aria-label="Reference 14" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR14" id="ref-link-section-d119306661e694" title="Huygelier H, Mattheus E, Abeele VV, van Ee R, Gillebert CR. The Use of the term virtual reality in Post-stroke Rehabilitation: a scoping review and Commentary. Psychol Belg. 2021;61(1):145–62.">14</a>]. More recently, MR systems have been developed [<a aria-label="Reference 15" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR15" id="ref-link-section-d119306661e697" title="Evron I, Schwartz O, Sajina A, Grosman-Rimon L, Dudkiewicz I. A digital exercise and augmented reality training system improved mobility among stroke patients: a randomized control trial. Technol Health Care. 2023.">15</a>]
that offer individuals a hybrid experience by combining real objects
and virtual environments to create a captivating midway point between
these two realities [<a aria-label="Reference 14" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR14" id="ref-link-section-d119306661e700" title="Huygelier H, Mattheus E, Abeele VV, van Ee R, Gillebert CR. The Use of the term virtual reality in Post-stroke Rehabilitation: a scoping review and Commentary. Psychol Belg. 2021;61(1):145–62.">14</a>].
MR can be classified as augmented reality and augmented virtuality
systems. Augmented reality involves overlaying virtual information onto
the physical environment whereas in augmented virtuality, real-world
data is superimposed onto a virtual environment.</p><p>In the context of
upper limb rehabilitation using XR, hand tracking and controllers are
commonly employed as input devices to enable users to interact with the
virtual environment [<a aria-label="Reference 14" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR14" id="ref-link-section-d119306661e706" title="Huygelier H, Mattheus E, Abeele VV, van Ee R, Gillebert CR. The Use of the term virtual reality in Post-stroke Rehabilitation: a scoping review and Commentary. Psychol Belg. 2021;61(1):145–62.">14</a>, <a aria-label="Reference 16" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR16" id="ref-link-section-d119306661e709" title="Wu J, Zeng A, Chen Z, Wei Y, Huang K, Chen J, et al. Effects of virtual reality training on Upper Limb function and balance in Stroke patients: systematic review and Meta-Meta-analysis. J Med Internet Res. 2021;23(10):e31051.">16</a>].
Hand-tracking technology measures hand position using HMDs equipped
with infrared detectors or other specialized hardware (e.g., Leap
Motion®), providing realistic visual feedback of hand and finger
positions. However, current XR systems using hand-tracking technology do
not allow for the provisioning of tactile feedback. On the other hand,
controllers equipped with buttons and inertial measurement units enable
the delivery of haptic feedback, but with limited visual feedback and
positioning capabilities. Virtual representations of hand and fingers
are not always available, and when they are, they do not always reflect
natural hand positions. Most systems incorporating controllers tend to
employ pre-determined hand poses that dynamically change based on the
buttons pressed and the controller’s position, rather than accurately
reflecting the real positions of hands and fingers. Both input methods
(hand-tracking technology and controllers) have unique advantages and
can be utilized based on the specific rehabilitation needs and goals of
the individual.</p><p>Recently, VR has transcended its role as a
therapeutic tool and has emerged as a valuable means of assessing upper
limb body function [<a aria-label="Reference 17" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR17" id="ref-link-section-d119306661e715" title="Chung CR, Su MC, Lee SH, Wu EH, Tang LH, Yeh SC. An Intelligent Motor Assessment Method Utilizing a bi-lateral virtual-reality Task for Stroke Rehabilitation on Upper Extremity. IEEE J Transl Eng Health Med. 2022;10:2100811.">17</a>], cognition [<a aria-label="Reference 18" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR18" id="ref-link-section-d119306661e718" title="Ajana K, Everard G, Lejeune T, Edwards MG. A feature and conjunction visual search immersive virtual reality serious game for measuring spatial and distractor inhibition attention using response time and action kinematics. J Clin Exp Neuropsychol. 2023;45(3):292–303.">18</a>, <a aria-label="Reference 19" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR19" id="ref-link-section-d119306661e721" title="Knobel SEJ, Kaufmann BC, Gerber SM, Cazzoli D, Müri RM, Nyffeler T, et al. Immersive 3D virtual reality Cancellation Task for Visual Neglect Assessment: a pilot study. Front Hum Neurosci. 2020;14:180.">19</a>] and activities [<a data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR20" id="ref-link-section-d119306661e724" title="Everard G, Otmane-Tolba Y, Rosselli Z, Pellissier T, Ajana K, Dehem S, et al. Concurrent validity of an immersive virtual reality version of the Box and Block Test to assess manual dexterity among patients with stroke. J Neuroeng Rehabil. 2022;19(1):7.">20</a>,<a data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR21" id="ref-link-section-d119306661e724_1" title="Burton Q, Lejeune T, Dehem S, Lebrun N, Ajana K, Edwards MG, et al. Performing a shortened version of the Action Research Arm Test in immersive virtual reality to assess post-stroke upper limb activity. J Neuroeng Rehabil. 2022;19(1):133.">21</a>,<a aria-label="Reference 22" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR22" id="ref-link-section-d119306661e727" title="Adams RJ, Lichter MD, Krepkovich ET, Ellington A, White M, Diamond PT. Assessing upper extremity motor function in practice of virtual activities of daily living. IEEE Trans Neural Syst Rehabil Eng. 2015;23(2):287–96.">22</a>].
This assessment approach offers several advantages over traditional
outcome measures. Firstly, VR allows for the implementation of
computerized standardized protocols, effectively reducing the risk of
inter and intra-rater bias. Secondly, it facilitates the measurement of
multiple quantitative and objective variables, notably including
reaction time, response time and kinematics, providing complementary
performance measures that together build a more comprehensive
understanding of the patient’s progress. Thirdly, once patients have
been trained in VR assessment, they may gain the ability to conduct
assessments independently, presenting the opportunity to increase the
frequency of evaluations, even within the comfort of their homes.</p><p>Several
iterations of the BBT have been developed in VR. Notably, two studies
have demonstrated strong correlations between scores obtained in
non-immersive VR versions and those of the traditional BBT [<a aria-label="Reference 23" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR23" id="ref-link-section-d119306661e734" title="Cho S, Kim WS, Paik NJ, Bang H. Upper-Limb function Assessment using VBBTs for stroke patients. IEEE Comput Graph Appl. 2016;36(1):70–8.">23</a>, <a aria-label="Reference 24" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR24" id="ref-link-section-d119306661e737" title="Alvarez-Rodríguez M, López-Dolado E, Salas-Monedero M, Lozano-Berrio V, Ceruelo-Abajo S, Gil-Agudo A, et al. Concurrent validity of a virtual version of Box and Block Test for patients with neurological disorders. World J Neurosci. 2020;10(01):79.">24</a>]. The first study was conducted among individuals with stroke [<a aria-label="Reference 23" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR23" id="ref-link-section-d119306661e740" title="Cho S, Kim WS, Paik NJ, Bang H. Upper-Limb function Assessment using VBBTs for stroke patients. IEEE Comput Graph Appl. 2016;36(1):70–8.">23</a>] and the second among healthy participants and individuals with spinal cord injury [<a aria-label="Reference 24" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR24" id="ref-link-section-d119306661e743" title="Alvarez-Rodríguez M, López-Dolado E, Salas-Monedero M, Lozano-Berrio V, Ceruelo-Abajo S, Gil-Agudo A, et al. Concurrent validity of a virtual version of Box and Block Test for patients with neurological disorders. World J Neurosci. 2020;10(01):79.">24</a>].
Oña et al. took a step further by developing the first iVR BBT using an
HMD and hand-tracking technology (Leap Motion®) to measure hand and
finger movements [<a aria-label="Reference 25" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR25" id="ref-link-section-d119306661e746" title="Oña ED, Jardón A, Cuesta-Gómez A, Sánchez-Herrera-Baeza P, Cano-de-la-Cuerda R, Balaguer C. Validity of a Fully-Immersive VR-Based Version of the Box and Blocks Test for Upper Limb Function Assessment in Parkinson’s Disease. Sens (Basel). 2020;20(10).">25</a>].
Their study revealed a moderate correlation between the virtual BBT and
traditional BBT scores among individuals with Parkinson Disease [<a aria-label="Reference 25" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR25" id="ref-link-section-d119306661e750" title="Oña ED, Jardón A, Cuesta-Gómez A, Sánchez-Herrera-Baeza P, Cano-de-la-Cuerda R, Balaguer C. Validity of a Fully-Immersive VR-Based Version of the Box and Blocks Test for Upper Limb Function Assessment in Parkinson’s Disease. Sens (Basel). 2020;20(10).">25</a>]. In a study by Dong et al., another immersive virtual BBT was designed, employing a specific haptic device [<a aria-label="Reference 26" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR26" id="ref-link-section-d119306661e753" title="Dong Y, Liu X, Tang M, Huo H, Chen D, Wu Z, et al. A haptic-feedback virtual reality system to improve the box and block test (BBT) for upper extremity motor function assessment. Virtual Reality. 2023;27(2):1199–219.">26</a>]. The outcomes indicated moderate correlations between virtual and traditional versions of the test [<a aria-label="Reference 26" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR26" id="ref-link-section-d119306661e756" title="Dong Y, Liu X, Tang M, Huo H, Chen D, Wu Z, et al. A haptic-feedback virtual reality system to improve the box and block test (BBT) for upper extremity motor function assessment. Virtual Reality. 2023;27(2):1199–219.">26</a>].
Similarly, we created an iVR BBT that employed controllers to
manipulate and move the virtual blocks, while the HMD provided visual
feedback [<a aria-label="Reference 20" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR20" id="ref-link-section-d119306661e759" title="Everard G, Otmane-Tolba Y, Rosselli Z, Pellissier T, Ajana K, Dehem S, et al. Concurrent validity of an immersive virtual reality version of the Box and Block Test to assess manual dexterity among patients with stroke. J Neuroeng Rehabil. 2022;19(1):7.">20</a>].
Results demonstrated strong correlations between the number of blocks
moved by individuals with stroke during the virtual and traditional BBT [<a aria-label="Reference 20" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR20" id="ref-link-section-d119306661e762" title="Everard G, Otmane-Tolba Y, Rosselli Z, Pellissier T, Ajana K, Dehem S, et al. Concurrent validity of an immersive virtual reality version of the Box and Block Test to assess manual dexterity among patients with stroke. J Neuroeng Rehabil. 2022;19(1):7.">20</a>].
More recently, to further enhance the assessment process, a new manual
dexterity test inspired by the BBT has been developed in MR using real
blocks and an interactive non-immersive virtual environment display
(REAtouch®, AXINESIS®, Belgium).</p><p>While several studies have
explored the validity of VR-based BBT versions, a significant gap in the
literature remains. To date, there have been no comprehensive
investigations that directly compare different VR versions of BBT
assessments, specifically contrasting responses made with hand-tracking
vs. haptic devices. Hand-tracking technology may lead to improved sense
of presence and more effective interaction when compared to haptic
devices, but the accuracy and reliability of this technique remains
debated [<a aria-label="Reference 27" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR27" id="ref-link-section-d119306661e768" title="Buckingham G. Hand tracking for immersive virtual reality: opportunities and challenges. Front Virtual Real. 2021;2:728461.">27</a>].
Moreover, the validity of developing a manual dexterity test in MR
remains under-explored. Yet, such developments could be of interest as,
in contrast with hand-tracking and controller technologies, MR systems
allow users to manipulate real word objects, therefore providing true
haptic feedback. Addressing this research void is essential for gaining a
comprehensive understanding of the relative advantages and limitations
of these input modalities. Furthermore, to date, few studies have
explored the potential of XR reality to assess upper limb kinematics.
This study first aimed to bridge this gap by comparing the content and
convergent validity of different XR BBT versions and manual dexterity
tests using hand-tracking, controllers, and MR among healthy
participants and individuals with stroke. We first hypothesized that
scores from the iVR and MR tests versions would be strongly correlated
to the traditional BBT. We also hypothesized that, on average,
participants would displace more blocks in the traditional test and when
using hand-tracking technology than when using controllers [<a aria-label="Reference 27" data-test="citation-ref" data-track-action="reference anchor" data-track-label="link" data-track="click" href="https://jneuroengrehab.biomedcentral.com/articles/10.1186/s12984-024-01332-x#ref-CR27" id="ref-link-section-d119306661e771" title="Buckingham G. Hand tracking for immersive virtual reality: opportunities and challenges. Front Virtual Real. 2021;2:728461.">27</a>].
Secondary objectives were to assess and compare the reliability and
usability of the different iVR and MR tests. Lastly, we aimed to compare
upper limb kinematics that were acquired in iVR between individuals
with stroke and healthy participants.</p></div></div></section></div>oc1deanhttp://www.blogger.com/profile/02302555382262295577noreply@blogger.com0tag:blogger.com,1999:blog-151811238595694978.post-5614106559158648842024-03-16T01:25:00.001-04:002024-03-16T01:25:21.228-04:00Intravenous Alteplase Versus Best Medical Therapy for Patients With Minor Stroke: A Systematic Review and Meta-Analysis<h3 style="text-align: left;">It doesn't look like you measured either against 100% recovery as defined by the survivor! So fucking useless research! Survivors don't care how minor the stroke is you blithering idiots, they still want 100% recovery! <span style="color: red;"><span style="font-size: x-large;">GET THERE!</span></span></h3><h3 style="text-align: left;"><a href="http://oc1dean.blogspot.com/2016/10/whats-measured-improves-so-said.html"><u>“What's measured, improves.” So said management legend and author Peter F. Drucker </u></a></h3><h3 style="text-align: left;"></h3><h3 class="citation__title" style="text-align: left;"><u><a href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.045495" target="_blank">Intravenous Alteplase Versus Best Medical Therapy for Patients With Minor Stroke: A Systematic Review and Meta-Analysis</a></u></h3><div class="citation__title" style="text-align: left;"><h1 class="citation__title"></h1><div class="loa-wrapper hidden-xs"> <div class="accordion" id="sb-1"> <div class="accordion-tabbed loa-accordion"> <div class="accordion-tabbed__tab-mobile accordion__closed "><span></span><a class="author-name accordion-tabbed__control visible-x" data-db-target-for="a1" data-id="a1" href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.045495#" title="Yang Zhang"><span>Yang Zhang</span></a>, </div> <div class="accordion-tabbed__tab-mobile "><span></span><a class="author-name accordion-tabbed__control visible-x" data-db-target-for="a2" data-id="a2" href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.045495#" title="Tian Lv"><span>Tian Lv</span></a>, </div> <div class="accordion-tabbed__tab-mobile "><span></span><a class="author-name accordion-tabbed__control visible-x" data-db-target-for="a3" data-id="a3" href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.045495#" title="Thanh N. Nguyen"><span>Thanh N. Nguyen</span></a>, </div> <div class="accordion-tabbed__tab-mobile "><span></span><a class="author-name accordion-tabbed__control visible-x" data-db-target-for="a4" data-id="a4" href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.045495#" title="Simiao Wu"><span>Simiao Wu</span></a>, </div> <div class="accordion-tabbed__tab-mobile "><span></span><a class="author-name accordion-tabbed__control visible-x" data-db-target-for="a5" data-id="a5" href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.045495#" title="Zhi Li"><span>Zhi Li</span></a>, </div> <div class="accordion-tabbed__tab-mobile "><span></span><a class="author-name accordion-tabbed__control visible-x" data-db-target-for="a6" data-id="a6" href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.045495#" title="Xue Bai"><span>Xue Bai</span></a>, </div> <div class="accordion-tabbed__tab-mobile "><span></span><a class="author-name accordion-tabbed__control visible-x" data-db-target-for="a7" data-id="a7" href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.045495#" title="Dan Chen"><span>Dan Chen</span></a>, </div> <div class="accordion-tabbed__tab-mobile "><span></span><a class="author-name accordion-tabbed__control visible-x" data-db-target-for="a8" data-id="a8" href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.045495#" title="Chuansheng Zhao"><span>Chuansheng Zhao</span></a>, </div> <div class="accordion-tabbed__tab-mobile "><span></span><a class="author-name accordion-tabbed__control visible-x" data-db-target-for="a9" data-id="a9" href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.045495#" title="Wanyi Lin"><span>Wanyi Lin</span></a>, </div> <div class="accordion-tabbed__tab-mobile "><span></span><a class="author-name accordion-tabbed__control visible-x" data-db-target-for="a10" data-id="a10" href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.045495#" title="Shiqin Chen"><span>Shiqin Chen</span></a> and </div> <div class="accordion-tabbed__tab-mobile "><span></span><a class="author-name accordion-tabbed__control visible-x" data-db-target-for="a11" data-id="a11" href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.045495#" title="Yi Sui"><span>Yi Sui</span><i aria-hidden="true" class="icon-Email"></i></a> </div> </div> </div> </div> <div class="epub-section"><span class="epub-section__item"><span class="epub-section__state">Originally published</span><span class="epub-section__date">11 Mar 2024</span></span><span class="epub-section__item"><a class="epub-section__doi__text" href="https://doi.org/10.1161/STROKEAHA.123.045495">https://doi.org/10.1161/STROKEAHA.123.045495</a></span><span class="epub-section__item">Stroke. 2024;0</span></div><div class="article__body show-references"><div class="hlFld-Abstract"><a name="abstract"></a><div class="sectionInfo abstractSectionHeading"><h3 class="article-section__title section__title to-section" id="d65394982e1" style="text-align: left;">Abstract</h3></div><div class="abstractSection abstractInFull"><div class="anchor-spacer" id="acd1e324"></div><h3 class="article-section__title" id="d1e324">Background:</h3><p>The
efficacy of thrombolysis (IVT) in minor stroke (National Institutes of
Health Stroke Scale score, 0–5) remains inconclusive. The aim of this
study is to compare the effectiveness and safety of IVT with best
medical therapy (BMT) by means of a systematic review and meta-analysis
of randomized controlled trials and observational studies.</p><div class="anchor-spacer" id="acd1e331"></div><h3 class="article-section__title" id="d1e331">Methods:</h3><p>We
searched the PubMed, Embase, Cochrane Library, and Web of Science
databases to obtain articles related to IVT in minor stroke from
inception until August 10, 2023. The primary outcome was an excellent
functional outcome, defined as a modified Rankin Scale score of 0 or 1
at 90 days. The associations were calculated for the overall and
preformulated subgroups by using the odds ratios (ORs). This study was
registered with PROSPERO (CRD42023445856).</p><div class="anchor-spacer" id="acd1e338"></div><h3 class="article-section__title" id="d1e338">Results:</h3><p>A
total of 20 high-quality studies, comprised of 13 397 patients with
acute minor ischemic stroke, were included. There were no significant
differences observed in the modified Rankin Scale scores of 0 to 1 (OR,
1.10 [95% CI, 0.89–1.37]) and 0 to 2 (OR, 1.16 [95% CI, 0.95–1.43]),
mortality rates (OR, 0.67 [95% CI, 0.39–1.15]), recurrent stroke (OR,
0.89 [95% CI, 0.57–1.38]), and recurrent ischemic stroke (OR, 1.09 [95%
CI, 0.68–1.73]) between the IVT and BMT group. There were differences
between the IVT group and the BMT group in terms of early neurological
deterioration (OR, 1.81 [95% CI, 1.17–2.80]), symptomatic intracranial
hemorrhage (OR, 7.48 [95% CI, 3.55–15.76]), and hemorrhagic
transformation (OR, 4.73 [95% CI, 2.40–9.34]). Comparison of modified
Rankin Scale score of 0 to 1 remained unchanged in subgroup patients
with nondisabling deficits or compared with those using antiplatelets.</p><div class="anchor-spacer" id="acd1e345"></div><h3 class="article-section__title" id="d1e345">Conclusions:</h3><p>These
findings indicate that IVT does not yield significant improvement in
the functional prognosis of patients with acute minor ischemic stroke.
Additionally, it is associated with an increased risk of symptomatic
intracranial hemorrhage when compared with the BMT. Moreover, IVT may
not have superiority over BMT in patients with nondisabling deficits or
those using antiplatelets.</p></div><div class="abstractSection abstractInFull"><p></p><figure class="article__inlineFigure" id="fig0"><img alt="" class="figure__image" data-lg-src="/cms/asset/546d0c1d-d80f-465b-b79b-72e582bae419/strokeaha.123.045495.abstract1.jpg" src="https://www.ahajournals.org/cms/asset/66ecccb4-9251-48fb-a704-fc93a509e770/strokeaha.123.045495.abstract1.jpg" /><div class="figure-links"><ul class="rlist--inline"><li><a href="https://www.ahajournals.org/cms/asset/b1bbb4e6-6bb3-43fc-ad7f-efd741af74b1/strokeaha.123.045495.abstract1.jpg">Download figure</a></li><li><a class="ppt-figure-link" href="https://www.ahajournals.org/action/downloadFigures?id=fig0&doi=10.1161%2FSTROKEAHA.123.045495">Download PowerPoint</a></li></ul></div></figure></div></div></div></div>oc1deanhttp://www.blogger.com/profile/02302555382262295577noreply@blogger.com0tag:blogger.com,1999:blog-151811238595694978.post-8438828108302190122024-03-16T01:12:00.005-04:002024-03-16T01:40:37.143-04:00Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021<h3 style="text-align: left;">And yet with all this documentation, including for stroke, our <b><a href="http://oc1dean.blogspot.com/2016/11/why-i-use-term-fucking-failures-of.html" target="_blank"><u>fucking failures of stroke associations</u></a></b> have nothing planned to get to 100% recovery for all!<br /></h3><h3 class="article-header__title smaller" style="text-align: left;"><u><a href="https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(24)00038-3/fulltext?dgcid=twitter_organic_infocusbrainhealth_gbd24_laneur" target="_blank">Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021</a></u></h3><div class="article-header__title smaller" style="text-align: left;"><h2 class="top" data-left-hand-nav="Summary" id="seccestitle10" tabindex="-1"><span class="top__text">Summary</span></h2><div class="section-paragraph"><h3>Background</h3><div class="section-paragraph">Disorders
affecting the nervous system are diverse and include neurodevelopmental
disorders, late-life neurodegeneration, and newly emergent conditions,
such as cognitive impairment following COVID-19. Previous publications
from the Global Burden of Disease, Injuries, and Risk Factor Study
estimated the burden of 15 neurological conditions in 2015 and 2016, but
these analyses did not include neurodevelopmental disorders, as defined
by the International Classification of Diseases (ICD)-11, or a subset
of cases of congenital, neonatal, and infectious conditions that cause
neurological damage. Here, we estimate nervous system health loss caused
by 37 unique conditions and their associated risk factors globally,
regionally, and nationally from 1990 to 2021.</div><h3>Methods</h3><div class="section-paragraph">We
estimated mortality, prevalence, years lived with disability (YLDs),
years of life lost (YLLs), and disability-adjusted life-years (DALYs),
with corresponding 95% uncertainty intervals (UIs), by age and sex in
204 countries and territories, from 1990 to 2021. We included morbidity
and deaths due to neurological conditions, for which health loss is
directly due to damage to the CNS or peripheral nervous system. We also
isolated neurological health loss from conditions for which nervous
system morbidity is a consequence, but not the primary feature,
including a subset of congenital conditions (ie, chromosomal anomalies
and congenital birth defects), neonatal conditions (ie, jaundice,
preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic
echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic
neuropathy. By conducting a sequela-level analysis of the health
outcomes for these conditions, only cases where nervous system damage
occurred were included, and YLDs were recalculated to isolate the
non-fatal burden directly attributable to nervous system health loss. A
comorbidity correction was used to calculate total prevalence of all
conditions that affect the nervous system combined.</div><h3>Findings</h3><div class="section-paragraph">Globally,
the 37 conditions affecting the nervous system were collectively ranked
as the leading group cause of DALYs in 2021 (443 million, 95% UI
378–521), affecting 3·40 billion (3·20–3·62) individuals (43·1%,
40·5–45·9 of the global population); global DALY counts attributed to
these conditions increased by 18·2% (8·7–26·7) between 1990 and 2021.
Age-standardised rates of deaths per 100 000 people attributed to these
conditions decreased from 1990 to 2021 by 33·6% (27·6–38·8), and
age-standardised rates of DALYs attributed to these conditions decreased
by 27·0% (21·5–32·4). Age-standardised prevalence was almost stable,
with a change of 1·5% (0·7–2·4). The ten conditions with the highest
age-standardised DALYs in 2021 were<b><span style="color: #ff00fe;"> stroke</span></b>, neonatal encephalopathy,
migraine, Alzheimer's disease and other dementias, diabetic neuropathy,
meningitis, epilepsy, neurological complications due to preterm birth,
autism spectrum disorder, and nervous system cancer.</div><h3>Interpretation</h3><div class="section-paragraph">As
the leading cause of overall disease burden in the world, with
increasing global DALY counts, effective prevention, treatment, and
rehabilitation strategies for disorders affecting the nervous system are
needed.</div><div class="section-paragraph"></div><div class="section-paragraph"></div><div><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEidcUHNW36NwPfvXACkCLAOLRV1t01TeP12KiL2fK8h31n_1x400DtnXmXFF_8FxdxF3N8MT_Z5ol02bt3eSD6ImUfwci8p08UQlHl5-8UFgcbDixw6EHQRDILMXdZ6QHzu1xSeUtatgOc_yRL7Cr_gmLaHxB-fwh_vVP2An_sU9UeqEKg1d_so123BwHI/s1200/xx.jpeg"><img border="0" data-original-height="550" data-original-width="550" height="550" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEidcUHNW36NwPfvXACkCLAOLRV1t01TeP12KiL2fK8h31n_1x400DtnXmXFF_8FxdxF3N8MT_Z5ol02bt3eSD6ImUfwci8p08UQlHl5-8UFgcbDixw6EHQRDILMXdZ6QHzu1xSeUtatgOc_yRL7Cr_gmLaHxB-fwh_vVP2An_sU9UeqEKg1d_so123BwHI/w584-h582/xx.jpeg" width="550" /></a></div>You'll have to look at the link to get the vast numbers for stroke.<br /></div></div>oc1deanhttp://www.blogger.com/profile/02302555382262295577noreply@blogger.com0tag:blogger.com,1999:blog-151811238595694978.post-76151513524160051662024-03-15T20:41:00.001-04:002024-03-15T20:41:44.265-04:00 Motor and Premotor Cortices in Subcortical Stroke: Proton Magnetic Resonance Spectroscopy Measures and Arm Motor Impairment<h3 style="text-align: left;"><span style="color: red;"><span style="font-size: x-large;">Measurements DO ABSOLUTELY NOTHING FOR RECOVERY!</span></span></h3><h3 style="text-align: left;"><br /></h3><h3 style="text-align: left;"><u><a href="https://www.academia.edu/22106584/Metabolic_profile_of_motor_cortex_in_stroke?email_work_card=title" target="_blank"> Motor and Premotor Cortices in Subcortical Stroke: Proton Magnetic Resonance Spectroscopy Measures and Arm Motor Impairment</a></u></h3><div style="text-align: left;"> Sorin C. Craciunas, MD, PhD 1, </div><div style="text-align: left;">William M. Brooks, PhD 1, </div><div style="text-align: left;">Randolph J. Nudo, PhD 1, </div><div style="text-align: left;">Elena A. Popescu, PhD 1, </div><div style="text-align: left;">In-Young Choi, PhD 1, </div><div style="text-align: left;">Phil Lee, PhD 1, </div><div style="text-align: left;">Hung-Wen Yeh, PhD 1, </div><div style="text-align: left;">Cary R. Savage, PhD 1, and </div><div style="text-align: left;">Carmen M. Cirstea, MD, PhD 1<br /><h3 style="text-align: left;">Abstract</h3><b>Background </b> </div><div style="text-align: left;"> </div><div style="text-align: left;">Although functional imaging and neurophysiological approaches reveal alterations in motor and premotor areas after stroke, insights into neurobiological events underlying these alterations are limited in human studies.<br /><b>Objective</b> </div><div style="text-align: left;"> </div><div style="text-align: left;">We tested whether cerebral metabolites related to neuronal and glial compartments are altered in the hand representation in bilateral motor and premotor areas and correlated with distal and proximal arm motor impairment in hemiparetic persons.<br /><b> Methods</b> </div><div style="text-align: left;"> </div><div style="text-align: left;">In 20 participants at >6 months post onset of a subcortical ischemic stroke and 16 age- and sex-matched healthy controls, the concentrations of N-acetylaspartate and myo-inositol were quantified by proton magnetic resonance spectroscopy. Regions of interest identified by functional magnetic resonance imaging included primary (M1), dorsal premotor (PMd), and supplementary (SMA) motor areas. Relationships between metabolite concentrations and distal (hand) and proximal (shoulder/elbow) motor impairment using Fugl-Meyer Upper Extremity (FMUE) subscores were explored.<br /><b>Results</b> </div><div style="text-align: left;"> </div><div style="text-align: left;">N-Acetylaspartate was lower in M1 (P = .04) and SMA (P = .004) and myo-inositol was higher in M1 (P<br /> = .003) and PMd (P = .03) in the injured (ipsilesional) hemisphere after stroke compared with the left hemisphere in controls.<br />N-Acetylaspartate in ipsilesional M1 was positively correlated with hand FMUE subscores (P = .04). Significant positive correlations were also found between N-acetylaspartate in ipsilesional M1, PMd, and SMA and in contralesional M1 and shoulder/elbow FMUE subscores (P = .02, .01, .02, and .02, respectively).<br /><b>Conclusions</b> </div><div style="text-align: left;"> </div><div style="text-align: left;">Our preliminary results demonstrated that proton magnetic resonance spectroscopy is a sensitive method to quantify relevant neuronal changes in spared motor cortex after stroke and consequently increase our knowledge of the factors leading from these changes to arm motor impairment.<br /></div>oc1deanhttp://www.blogger.com/profile/02302555382262295577noreply@blogger.com0tag:blogger.com,1999:blog-151811238595694978.post-33586705297335914252024-03-15T20:13:00.000-04:002024-03-15T20:13:04.246-04:00Stroke Literature Synopsis (Clinical)<h3 style="text-align: left;"> FYI.</h3><h3 class="citation__title" style="text-align: left;"><u><a href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.124.046105" target="_blank"><i>Stroke</i> Literature Synopsis (Clinical)</a></u></h3><div class="citation__title" style="text-align: left;"><div class="loa-wrapper hidden-xs"> <div class="accordion" id="sb-1"> <div class="accordion-tabbed loa-accordion"> <div class="accordion-tabbed__tab-mobile accordion__closed"><span></span><a class="author-name accordion-tabbed__control visible-x" data-db-target-for="a1" data-id="a1" href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.124.046105#" title="Meghan Minnis"><span>Meghan Minnis</span></a> and </div> <div class="accordion-tabbed__tab-mobile"><span></span><a class="author-name accordion-tabbed__control visible-x" data-db-target-for="a2" data-id="a2" href="https://www.ahajournals.org/doi/10.1161/STROKEAHA.124.046105#" title="Terence J. Quinn"><span>Terence J. Quinn</span><i aria-hidden="true" class="icon-Email"></i></a> </div> </div> </div> </div> <div class="epub-section"><span class="epub-section__item"><span class="epub-section__state">Originally published</span><span class="epub-section__date">26 Feb 2024</span></span><span class="epub-section__item"><a class="epub-section__doi__text" href="https://doi.org/10.1161/STROKEAHA.124.046105">https://doi.org/10.1161/STROKEAHA.124.046105</a></span><span class="epub-section__item">Stroke. 2024;55:e50–e51</span></div><div class="article__body show-references"><p class="fulltext"></p><div class="hlFld-Abstract"><p class="fulltext"></p></div><div class="hlFld-Fulltext"><p>Atrial
fibrillation (AF) is the commonest arrhythmia and represents a major
challenge in stroke. AF predisposes to cardioembolic stroke, and while
anticoagulation therapy can reduce ischemic stroke risk, it can also
bring bleeding issues that are equally dangerous. This synopsis will
review 3 studies with a clinical AF focus.</p><p>For people living with
AF, risk of cardioembolic stroke is not consistent and anticoagulation
therapy is reserved for those at higher risk. The term subclinical AF is
used to describe short-duration, asymptomatic episodes. Whether the
stroke risk associated with this arrhythmia merits anticoagulation has
been unclear. This provides the rationale for the ARTESiA trial
([Apixaban for the Reduction of Thrombo-Embolism in Patients With
Device-Detected Subclinical Atrial Fibrillation]; <b>Healey JS, et al. Apixaban for stroke prevention in subclinical atrial fibrillation. <i>N Engl J Med</i>. 2024;390:107–117. doi: 10.1056/NEJMoa2310234</b>).
This trial enrolled people with subclinical AF lasting between 6
minutes to 24 hours picked up on an implanted pacemaker, defibrillator,
or cardiac monitor. Participants were randomized to either receive the
direct oral anticoagulant (DOAC) apixaban or aspirin. The primary
outcome was stroke or systemic embolism, assessed in the intention to
treat population, while the safety outcome was major bleeding assessed
in the on-treatment population.</p><p>The study participants were 4012
patients across 16 countries, all aged 75 years or over, and at risk of
stroke. The mean study follow-up was 3.5 years. The mean duration of
detected AF was 1.4 hours. The risk of stroke or embolism was 37% lower
in the apixaban arm (95% CI, 12–55), and risk of disabling or fatal
stroke was 49% lower. However, the group taking apixaban was also at
increased risk of major bleeding (hazard ratio, 1.80 [95% CI,
1.26–2.57), although, the risk of fatal or intracranial hemorrhage (ICH)
was similar between arms. The authors argue that as bleeding is more
amenable to reversal or treatment than ischemic stroke, then these data
favor anticoagulant treatment in subclinical AF. ARTESIA also reminds us
that cardioembolic strokes can be associated with substantial
disability and that aspirin is not free from bleeding risk.</p><p>Even
with anticoagulation therapy people with AF remain at risk of stroke. A
common clinical dilemma is how to treat acute ischemic stroke when the
person is anticoagulated. Traditional guidance stated that exposure to
therapeutic levels of anticoagulant was an absolute contraindication to
systemic thrombolysis due to risk of bleeding. However, this view was
primarily based on studies of vitamin K antagonists such as warfarin. As
DOACs have a different mode of action, pharmacokinetics, and
pharmacodynamics, observations from warfarin may not be valid with these
drugs. An international, multicenter analysis aimed to provide more
evidence on thrombolysis and DOACs (<b>Meinel TR, et al. Intravenous thrombolysis in patients with ischemic stroke and recent ingestion of direct oral anticoagulants. <i>JAMA Neurol</i>. 2023;80:233</b>–<b>243. doi: 10.1001/jamaneurol.2022.4782</b>).
The authors collated individual patient-level data from multiple
international registers and cohorts, pooling the data to create a
case-control study comparing those with ingestion of DOAC 48 hours
before intravenous thrombolysis against those with no anticoagulant
exposure. The primary outcome was symptomatic ICH.</p><p>Data from over
33 000 patients were included in the analysis, 832 with recent DOAC
ingestion and 32 375 without. Those in the DOAC group were typically
older, with greater prestroke disability and comorbidity. Interventions
to reverse anticoagulation were used in 252 (30%) of the DOAC group. The
authors found that, after adjusting for baseline predictors of
bleeding, recent DOAC ingestion was not associated with an increased
risk of symptomatic ICH; in fact, there was a suggestion of lesser risk
(adjusted odds ratio, 0.57 [95% CI, 0.36–0.92]). Functional outcomes
were similar between groups, again with data favoring the DOAC exposure
group (adjusted odds ratio, 1.13 [95% CI, 0.94–1.36]). These results
challenge the assumption that DOAC therapy is a barrier to thrombolysis.
However, observational data come with many caveats including the risk
of selection bias. Robust prospective trials may be necessary to
definitively settle the issue and support changes to current guidelines.</p><p>For
those with AF who experience ICH, there are yet more difficult
therapeutic decisions. The benefits of anticoagulation for reducing the
risk of ischemic stroke must be balanced against the risk of
precipitating or worsening another bleed. Useful data come from the
COCROACH (Collaboration of Controlled Randomised Trials of Long-Term
Oral Antithrombotic Agents After Spontaneous Intracranial Haemorrhage)
group. The group performed an individual patient-level data
meta-analysis of 4 trials, which included patients with spontaneous ICH
and AF who were randomized to (re)start anticoagulation or avoid
anticoagulation (<b>Al-Shahi Salman R, et al. Effects of oral
anticoagulation in people with atrial fibrillation after spontaneous
intracranial haemorrhage (COCROACH): prospective, individual participant
data meta-analysis of randomised trials. <i>Lancet Neurol</i>. 2023;22:1140–1149. doi: 10.1016/S1474-4422(23)00315-0</b>). The primary outcome of interest was a composite of cardiovascular events, stroke (ischemic and hemorrhagic), and death.</p><p>In
total, 412 people with AF were included in the meta-analysis. Of these,
212 participants (51.5%) were assigned to start anticoagulation, almost
exclusively DOACs. A third of patients who did not receive
anticoagulation were prescribed antiplatelet monotherapy. The primary
outcome occurred in 14% of the anticoagulation arm, compared with 22% of
those not anticoagulated (hazard ratio, 0.68 [95% CI, 0.42 to 1.10]).
No significant differences were seen in rates of ICH, but there was a
suggestion of increased bleeding with anticoagulation (7% if
anticoagulated, 5% if not, hazard ratio, 1.80 [95% CI, 0.77 to 4.21]).
No difference was found between groups for death or dependence at 1
year. These are useful data for informing discussions around
anticoagulation and highlight the power of individual patient-level data
approaches. However, even these pooled data may give a sample size too
small to definitively answer questions around ICH and anticoagulation,
especially in subgroups. There are 5 active trials looking at
anticoagulation following ICH, and we await these results and subsequent
updated meta-analyses.</p><p>For stroke clinicians, the trade-off
between reducing ischemic events and not increasing bleeding events can
feel like we are stuck between a rock and a hard place. In this context,
research is vital to provide an evidence base to assist with
decision-making. The studies presented here resolve some of the
controversies and open up new questions requiring more research.</p><div class="anchor-spacer" id="acd1e227"></div><h3 class="article-section__title to-section" id="d1e227">ARTICLE INFORMATION</h3><div class="articleInformation"><div class="anchor-spacer" id="acd1e231"></div><h4 class="article-section__title" id="d1e231">Sources of Funding</h4><p>None.</p></div></div><h3 class="article-section__title to-section" id="d55537110e75">Footnotes</h3><div class="NLM_author-notes"><p>For Sources of Funding and Disclosures, see page e51.</p><div class="NLM_corresp">Correspondence
to: Terence J. Quinn, MD, School of Cardiovascular and Metabolic
Health, University of Glasgow, New Lister Bldg Campus, Glasgow Royal
Infirmary, Alexandra Parade, Glasgow, United Kingdom, G31 2ER. Email <a class="references__email" href="mailto:mailto:terry.quinn@glasgow.ac.uk"><span class="nobrWithWbr">terry.<wbr></wbr>quinn@glasgow.<wbr></wbr>ac.<wbr></wbr>uk</span></a></div></div><div class="response"><div class="sub-article-title"></div></div></div><div class="purchaseArea">
<div class="comments__wrapper">
<div class="comments__wrapper__header"><div class="article__body"><h2 class="comments__title to-section" id="comments"><span><br /></span><span class="comments__count"></span></h2></div></div></div></div></div>oc1deanhttp://www.blogger.com/profile/02302555382262295577noreply@blogger.com0tag:blogger.com,1999:blog-151811238595694978.post-70231147935329706792024-03-15T20:11:00.001-04:002024-03-15T20:11:24.126-04:00Relationship Between Body-Specific Attention to a Paretic Limb and Real-World Arm Use in Stroke Patients: A Longitudinal Study<h3 style="text-align: left;">Well shit, research is still uselessly
going on about nonuse. It's just a convenient way to blame the patient
for not recovering when the doctor should be blamed for not getting 100%
recovery protocols created. I consider upper limb monitors absolutely
fucking useless and any research into nonuse a fireable offense! They
are only used to shame the survivor about not using the affected arm. I
never use my affected arm, it is totally useless for any tasks!<br /></h3><h3 style="text-align: left;">Damn
it all, it is NOT learned nonuse. It is the actual inability to use it
because of dead neurons. If you had dead brain rehab protocols, this
fake learned nonuse idea would cease to exist! <span style="color: red;"><span style="font-size: x-large;">Quit
blaming the patient for not recovering and blame the doctor and
therapists for knowing nothing on how to get survivors recovered! </span></span></h3><h3 style="text-align: left;"><span style="color: red;"><span style="font-size: x-large;">Do you blithering idiots ever actually think about why stroke patients don't recover? </span></span></h3><h3 style="text-align: left;"></h3><ul style="text-align: left;"><li><h3>
<a dir="ltr" href="http://oc1dean.blogspot.com/search/label/learned%20nonuse"><u>learned nonuse</u></a>
<span dir="ltr">(11 posts to May 2018)</span></h3></li><li><h3>
<a dir="ltr" href="http://oc1dean.blogspot.com/search/label/nonuse"><u>nonuse</u></a>
<span dir="ltr">(14 posts to May 2013)</span>
</h3></li></ul><p> </p><h3 id="swp-tcr--title" style="text-align: left;"><u><a href="https://www.academia.edu/84983494/Relationship_Between_Body_Specific_Attention_to_a_Paretic_Limb_and_Real_World_Arm_Use_in_Stroke_Patients_A_Longitudinal_Study?email_work_card=title" target="_blank">Relationship Between Body-Specific Attention to a Paretic Limb and Real-World Arm Use in Stroke Patients: A Longitudinal Study</a></u></h3><div id="swp-tcr--title" style="text-align: left;"><br /> <br />ORIGINAL RESEARCH<br />published: 22 February 2022doi: 10.3389/fnsys.2021.806257<br /> Edited by:<br /> Jun Ota,The University of Tokyo, Japan<br /> Reviewed by:<br />Hiroshi Imamizu,The University of Tokyo, Japan Anna Danielsson,University of Gothenburg, SwedenKohei Kaminishi,The University of Tokyo, Japan<br />*Correspondence:<br />Shin-Ichi Izumi izumis@med.tohoku.ac.jp<br /> Received:<br /> 31 October 2021<br /> Accepted:<br /> 21 December 2021<br /> Published:<br /> 22 February 2022<br />Citation:<br />Otaki R, Oouchida Y, Aizu N, Sudo T,Sasahara H, Saito Y, Takemura S and Izumi S-I (2022) RelationshipBetween Body-Specific Attention to aParetic Limb and Real-World ArmUse in Stroke Patients: A Longitudinal Study.Front. Syst. Neurosci. 15:806257.doi: 10.3389/fnsys.2021.806257 <br />Relationship Between Body Specific Attention to a Paretic Limb and Real-World Arm Use in StrokePatients: A Longitudinal Study <br />Ryoji Otaki 1,2 , </div><div id="swp-tcr--title" style="text-align: left;">Yutaka Oouchida1,3, </div><div id="swp-tcr--title" style="text-align: left;">Naoki Aizu1,4, </div><div id="swp-tcr--title" style="text-align: left;">Tamami Sudo1,5, </div><div id="swp-tcr--title" style="text-align: left;">Hiroshi Sasahara 2,</div><div id="swp-tcr--title" style="text-align: left;">Yuki Saito 6, </div><div id="swp-tcr--title" style="text-align: left;">Sunao Takemura 6 and </div><div id="swp-tcr--title" style="text-align: left;">Shin-Ichi Izumi 1,7* <br />1 Department of Physical Medicine and Rehabilitation, Tohoku University Graduate School of Medicine, Sendai, Japan,<br /> 2 Department of Rehabilitation, Yamagata Saisei Hospital, Yamagata, Japan,<br /> 3 Department of Education, Osaka KyoikuUniversity, Osaka, Japan,<br /> 4 Faculty of Rehabilitation, School of Health Sciences, Fujita Health University, Toyoake, Japan,<br />5 Department of Computer and Information Sciences, Tokyo University of Agriculture and Technology, Tokyo, Japan,<br />6 Department of Neurosurgery, Yamagata Saisei Hospital, Yamagata, Japan,<br /> 7 Department of Physical Medicine and Rehabilitation, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan<br />Learned nonuse is a major problem in upper limb (UL) rehabilitation after stroke. Among the various factors that contribute to learned nonuse, recent studies have focused on body representation of the paretic limb in the brain. We previously developed a method to measure body specific attention, as a marker of body representation of the paretic limb and revealed a decline in body specific attention to the paretic limb in chronic stroke patients by a cross-sectional study. However, longitudinal changes in body specific attention and paretic arm use in daily life (real-world arm use) from the onset to the chronic phase, and their relationship, remain unknown. Here, in a longitudinal, prospective, observational study, we sought to elucidate the longitudinal changes in body specific attention to the paretic limb and real-world arm use, and their relationship, by using accelerometers and psychophysical methods, respectively, in25 patients with subacute stroke. Measurements were taken at baseline (T <sub>BL</sub>), 2 weeks(T <sub>2w</sub>), 1 month (T <sub>1M</sub>), 2 months (T <sub>2M</sub>), and 6 months (T <sub>6M</sub>) after enrollment. UL function was measured using the Fugl-Meyer Assessment (FMA) and Action Research Arm Test (ARAT). Real-world arm use was measured using accelerometers on both wrists.Body specific attention was measured using a visual detection task. The UL function and real-world arm use improved up to T <sub>6M</sub>. Longitudinal changes in body specific attention were most remarkable at T <sub>1M</sub>. Changes in body specific attention up to T <sub>1M</sub>correlated positively with changes in real-world arm use up to T <sub>6M</sub>, and from T <sub>1M</sub> to T <sub>6M</sub>,and the latter more strongly correlated with changes in real-world arm use. Changes in real world arm use up to T <sub>2M</sub> correlated positively with changes in FMA up to T <sub>2M</sub> and T <sub>6M</sub>. No correlation was found between body specific attention and FMA scores. Thus,these results suggest that improved body specific attention to the paretic limb during the early phase contributes to increasing long-term real-world arm use and that increased real world use is associated with the recovery of UL function. Our results may contribute to the development of rehabilitation strategies to enhance adaptive changes in body representation in the brain and increase real world arm use after stroke.</div>oc1deanhttp://www.blogger.com/profile/02302555382262295577noreply@blogger.com0tag:blogger.com,1999:blog-151811238595694978.post-56047107062803565612024-03-15T20:03:00.001-04:002024-03-15T20:03:54.655-04:00Mentoring the next generation of stroke researchers<h3 style="text-align: left;">Well maybe now we can get decent mentors that instructs all researchers to measure for and get to the goal of 100% recovery.</h3><h3 style="text-align: left;">So who needs to die before we get actual
stroke leadership and a strategy to get all survivors 100% recovered? I
hold out no hope for anyone currently in the field stepping up to take
on that leadership.</h3>
<h3 style="text-align: left;"><b>So who are the superstar researchers and supposed stroke leaders that are holding up
research by staying alive and preventing challenges to their field and
the current orthodoxy?</b> Yes this is way out there but proven true.
Found this quote in the book 'The Bonobo and the Atheist: In Search of
Humanism Among the Primates'. I've written about students that seems to
know more about stroke research than most of the research I've seen.</h3><h3 style="text-align: left;">
Michael Gazzangia interviewed in Annals of the New York Academy of
Sciences(The Year in Cognitive Neuroscience) 1224(2011), p.8. </h3>
<h3>
<a href="http://oc1dean.blogspot.com/2015/05/glasgow-student-creates-rehabilitation.html"><u>Glasgow student creates rehabilitation device to help stroke survivors</u></a></h3>
<h3>
<a href="http://oc1dean.blogspot.com/2012/10/student-start-up-company-develops.html"><u>Student Start-Up Company Develops Stroke Rehab App for iPad</u></a></h3>
<h3>
</h3>
<h3>
<a href="http://www.nber.org/papers/w21788" target="_blank"><u>Does Science Advance One Funeral at a Time?</u></a> Dec. 2015 </h3>
<h3 style="text-align: left;">The latest here; maybe now we can get stroke solved with the correct mentoring. <br /></h3><h3 class="long-title" id="page-h1" style="text-align: left;"><u><a href="https://web.musc.edu/about/news-center/2024/03/11/national-mentoring-award" target="_blank">Mentoring the next generation of stroke researchers</a></u></h3><div class="long-title" id="page-h1" style="text-align: left;"><h1 class="long-title" id="page-h1"></h1>
<div class="meta">
<div class="meta__author">
<a href="mailto:mcgheek@musc.edu" target="_self">Kimberly McGhee</a>
</div>
<div class="meta__posted">March 11, 2024</div>
</div>
<div class="rtf">
<figure>
<img alt="Slide announcing Dr. Marc Chimowitz'ss Ralph Sacco Outstanding Stroke Research Mentor Award" height="267" src="https://web.musc.edu/-/sm/news-center-media/news-center-images/2024-images/03/sacco-award.jpg?h=667&w=1000&la=en&hash=A76A8A79AC4702ADD051127EE1047C95" width="400" />
<figcaption>Dr. Marc Chimowitz received the Ralph L. Sacco Outstanding Stroke Research Mentor Award in Feburary.</figcaption>
</figure>
</div>
<div class="panel-collapse l-three-col">
<div class="rtf u-cf js-no-paste">
<p><a href="https://education.musc.edu/MUSCApps/FacultyDirectory/Chimowitz-Marc" title="MUSC Faculty Profile for Dr. Marc Chimowitz">Marc Chimowitz, MBChB</a>,
was awarded the inaugural Ralph L. Sacco Outstanding Stroke Research
Mentor Award by the American Stroke Association at its 2024
international stroke conference in Phoenix, Arizona.</p>
<p>Chimowitz is internationally recognized as a leader in overseeing
multisite stroke trials such as WASID, SAMMPRIS and CAPTIVA, many of
them having been rolled out through StrokeNet, a National Institutes of
Health-funded clinical trial network. The recent award, however,
recognized his contributions to mentoring the next generation of
physician-scientists in the field of stroke.</p>
<p>The award honors Ralph Sacco, M.D., who died in January of 2023.
Sacco was a past president of the American Heart Association and
American Stroke Association as well as the past director of the
University of Miami Clinical and Translational Science Institute.</p>
<figure class="u-float-r-mq-medium u-float-r-mq-large"> <img alt="Dr. Marc Chimowitz, professor emeritus of Neurology" src="https://web.musc.edu/-/sm/news-center-media/news-center-images/2024-images/03/chimowitz-headshotjpg.jpg?h=258&w=200&hash=A39F6E487EB9EE87A0C5220319701126" style="float: right; height: 258px; margin: 2px; width: 200px;" /> <figcaption>Dr. Marc Chimowitz</figcaption></figure>
<p>“Mentoring has been a great academic passion of mine, so it was an
honor to receive this award,” said Chimowitz. “The award was
particularly meaningful to me because Ralph Sacco co-directed the NIH
StrokeNet Prevention Working Group with me for seven years.” </p>
<p>Chimowitz, professor emeritus of Neurology at MUSC, was recruited
from Emory to MUSC in 2008 as associate dean for faculty development in
the College of Medicine to develop mentoring programs. He also served as
associate principal investigator and director of the multisite clinical
trials team and the KL2 training program for the South Carolina
Clinical & Translational Research (SCTR) Institute. The KL2 program
equips early-stage investigators to conduct independent translational
and clinical research.</p>
<p>“Dr. Chimowitz was an incredible mentor to numerous
clinician-scientists at Emory and MUSC, many of whom have gone on to
become successful researchers and leaders in their fields,” said SCTR
co-director <a href="https://education.musc.edu/MUSCApps/FacultyDirectory/Brady-Kathleen" title="MUSC faculty profile for Dr. Kathleen Brady">Kathleen Brady, M.D., Ph.D.</a>
“He also developed and led a number of innovative mentorship programs
that continue to benefit hundreds of junior faculty interested in
developing research careers.” </p>
<blockquote class="half">“In my view, there is nothing more rewarding in academic medicine than helping your mentees to succeed.”<br />
<br />
-- Dr. Marc Chimowitz</blockquote>
<p>Chimowitz formed the University Mentor Leadership Council, which
seeks to develop and enhance mentoring programs across campus. Under his
leadership, the council developed a framework for departmental
mentoring plans that has been implemented across campus and shared in a
2019 publication in the Journal of Clinical and Translational Science.
The council also organizes a monthly Tools for Mentors and Mentees
series and the Annual SCTR Mentorship Symposium, which continues to
bring experts in various facets of mentoring to Charleston.</p>
<p>As director of the KL2 program, Chimowitz coordinated mentoring
activities across all K, or research career development, programs and
started the K to R club to help K scholars with their applications for
R01 grants, which provide substantial funding to mature projects and
are considered the foundation for most research careers. He also began
an eight-week grant-writing course for K scholars and founded the
Society for Research and Translational Early Scientists (SOCRATES) so
that research trainees could collaborate and present their research to
peers and senior faculty members. He has provided one-on-one mentoring
of fellows and faculty at MUSC and other institutions in both clinical
care and research.</p>
<blockquote class="half">"Dr. Chimowitz was an incredible mentor to
numerous clinician-scientists at Emory and MUSC, many of whom have gone
on to become successful researchers and leaders in their fields."<br />
<br />
-- Dr. Kathleen Brady</blockquote>
<p>“If I were to choose one thing I learned from Dr. Chimowitz in
carrying out research, that would be integrity,” said stroke
neurologist-researcher <a href="https://providers.muschealth.org/sc/charleston/sami-al-kasab-md" title="MUSC Faculty Profile of Dr. Sami Al-Kasab">Sami Al Kasab, M.D.,</a>
of the Department of Neurosurgery at MUSC, one of Chimowitz’s mentees.
“This has taught me no matter how long it may take, ensuring the
integrity of my research work remains the top priority. I remember he
once told me, ‘you are better off having 50 highly impactful papers than
hundreds of papers that don’t help to advance the field.’”</p>
<p>For all these efforts, Chimowitz was recognized with MUSC’s
prestigious Peggy Schachte Research Mentoring Award and is now receiving
national recognition by the American Stroke Association.</p>
<p>Chimowitz’s years of mentoring and leading mentoring initiatives have
taught him some key lessons. You need a formal plan for mentoring,
which he has ensured that all departments at MUSC have. Mentorship is a
lifelong project and everyone, even senior mentors, should have mentors.
Finally, and perhaps most importantly, mentoring is a two-way street
and benefits both mentor and mentee.</p>
<p>“Mentoring should be a reciprocal relationship. I have learnt so much
from my mentees over the years, and we’ve had a lot of fun working
together,” said Chimowitz. “In my view, there is nothing more rewarding
in academic medicine than helping your mentees to succeed.”</p>
</div>
</div></div>oc1deanhttp://www.blogger.com/profile/02302555382262295577noreply@blogger.com0tag:blogger.com,1999:blog-151811238595694978.post-50167223638020791342024-03-15T18:53:00.000-04:002024-03-15T18:53:00.806-04:00Oriented Graphene Oxide Scaffold Promotes Nerve Regeneration in vitro and in vivo<h3 style="text-align: left;">Yeah, this is for peripheral nerves, but doesn't your competent? doctor have enough functioning brain cells to test this out for stroke recovery? <br /></h3><h3 style="text-align: left;"><u><a href="https://www.dovepress.com/articles.php?article_id=91190" target="_blank">Oriented Graphene Oxide Scaffold Promotes Nerve Regeneration in vitro and in vivo</a></u></h3><div style="text-align: left;"><div class="intro rs_skip">
<div class="padding">
<p>
<strong>Authors</strong> <a href="https://www.dovepress.com/author_profile.php?id=1971334" target="_blank">Zhou X</a> <a class="icon-orcid" href="https://orcid.org/0009-0006-8022-4515" target="_blank" title="https://orcid.org/0009-0006-8022-4515"></a>, <a href="https://www.dovepress.com/author_profile.php?id=1971372" target="_blank">Tang A</a>, <a href="https://www.dovepress.com/author_profile.php?id=1591441" target="_blank">Xiong C</a> <a class="icon-orcid" href="https://orcid.org/0000-0003-3318-1875" target="_blank" title="https://orcid.org/0000-0003-3318-1875"></a>, <a href="https://www.dovepress.com/author_profile.php?id=1971343" target="_blank">Zhang G</a> <a class="icon-orcid" href="https://orcid.org/0009-0007-2975-9546" target="_blank" title="https://orcid.org/0009-0007-2975-9546"></a>, <a href="https://www.dovepress.com/author_profile.php?id=1153560" target="_blank">Huang L</a>, <a href="https://www.dovepress.com/author_profile.php?id=1473563" target="_blank">Xu F</a> </p>
<p>
<strong>Received</strong> <abbr title="These are actual dates the paper was submitted to, accepted for, and published in the journal.">24 October 2023</abbr>
</p>
<p>
<strong>Accepted for publication</strong> 14 February 2024 </p>
<p>
<strong>Published</strong> 13 March 2024
Volume 2024:19 Pages 2573—2589 </p>
<p>
<strong>DOI</strong> <a href="https://doi.org/10.2147/IJN.S439656">https://doi.org/10.2147/IJN.S439656</a>
</p>
<p>
<strong>Checked for plagiarism</strong> Yes
</p>
<p>
<strong>Review by</strong> <a href="https://www.dovepress.com/peer-review-guidelines">Single anonymous peer review</a>
</p>
<p>
<strong>Peer reviewer comments</strong> 3 </p>
<p>
<strong>Editor who approved publication: </strong>
<a href="https://www.dovepress.com/public_profile.php?id=155308" target="_blank">Professor Lijie Grace Zhang</a>
</p>
</div>
</div>
<div class="rs_skip"><a class="download-btn print-hide" href="https://www.dovepress.com/getfile.php?fileID=97535" id="download-pdf">Download Article <span>[PDF]</span></a> </div> <br clear="all" /><br />
<p>Xu Zhou,<sup>1,</sup><sup>2,</sup><sup>*</sup> Aolin Tang,<sup>2,</sup><sup>3,</sup><sup>*</sup> Chengjie Xiong,<sup>2,</sup><sup>*</sup> Guoquan Zhang,<sup>2</sup> Liangliang Huang,<sup>1,</sup><sup>2</sup> Feng Xu<sup>1,</sup><sup>2</sup> <br /><br /><sup>1</sup>The First School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, People’s Republic of China; <sup>2</sup>Department of Orthopaedics, General Hospital of Central Theater Command, Wuhan, 430070, People’s Republic of China; <sup>3</sup>Department of Orthopaedics, Minda Hospital of Hubei Minzu University, Enshi, 445000, People’s Republic of China<br /><br />*These authors contributed equally to this work<br /><br />Correspondence:
Liangliang Huang; Feng Xu, Department of Orthopaedics, General Hospital
of Central Theater Command, Wuhan, 430070, People’s Republic of China,
Email hll666789@163.com; fengxu1969@163.com<br /><br /><strong>Background:</strong>
Treating peripheral nerve injuries (PNI) with defects remains
challenging in clinical practice. The commercial conduits have shown
suboptimal nerve regeneration and functional recovery due to their basic
tubular design without electroactive and oriented topographical cues.<br /><strong>Purpose:</strong>
To develop a new scaffold with oriented microstructure and
electroactive Graphene oxide (GO) and investigate its’ therapeutic
effect on nerve regeneration in vitro and in vivo.<br /><strong>Methods:</strong>
This study employed a straightforward approach to co-spin PCL and GO,
yielding an oriented hybrid nanofibrous scaffold known as the O-GO/PCL
scaffold. The physical and chemical properties of nanofibrous scaffold
were tested by scanning electron microscopy (SEM), transmission electron
microscope (TEM), tensile test and so on. Primary Schwann cells (SCs)
and dorsal root ganglia (DRG) were used to investigate the impact of the
newly developed scaffolds on the biological behavior of neural cells in
vitro. Transcriptome sequencing (mRNA-seq) was employed to probe the
underlying mechanisms of the synergistic effect of electroactive GO and
longitudinal topographic guidance on nerve regeneration. Furthermore,
the developed O-GO/PCL scaffold was utilized to bridge a 10-mm sciatic
nerve defect in rat, aiming to investigate its therapeutic potential for
peripheral nerve regeneration in vivo.<br /><strong>Results and discussion:</strong>
The SEM and TEM revealed that the newly developed O-GO/PCL scaffold
showed longitudinally oriented microstructure and GO particles were
homogenously and uniformly distributed inside the nanofibers. Primary
SCs were utilized to assess the biocompatibility of the GO-based
scaffold, revealing that negligible cytotoxicity when GO concentration
does not exceed 0.5%. In vitro analysis of nerve regeneration
demonstrated that axons in the O-GO/PCL group exhibited an average
length of 1054.88 ± 161.32 μm, significant longer than those in the
other groups (<em>P</em> < 0.05). Moreover, mRNA sequencing results
suggested that the O-GO/PCL scaffold could enhance nerve regeneration by
upregulating genes associated with neural regeneration, encompassing
ion transport, axon guidance and cell–cell interactions. Most
importantly, we employed the O-GO/PCL scaffold to repair a 10-mm sciatic
nerve defect in rat, resulting in augmented nerve regeneration,
myelination, and functional recovery.<br /><strong>Conclusion:</strong> The O-GO/PCL scaffold with oriented microstructure and electroactive GO represents a promising heral nerve reconstruction. <br /><br /><strong>Keywords:</strong> nanofibers, topographical guidance, electroactive, graphene oxide, nerve regeneration<br /></p> <div class="rs_skip">
<p><strong>Graphical Abstract:</strong></p>
<img height="213" src="https://www.dovepress.com/cr_data/cache/article_graphical_abstract/s439656/graphical_abstract.jpg" style="display: block; margin-bottom: 1em; max-width: 100%;" width="640" />
</div>
<h2>Introduction</h2>
<p>Peripheral nerve injury represents a prevalent global health issue, impacting over 5 million individuals worldwide.<sup><a href="https://www.dovepress.com/articles.php?article_id=91190#cit0001" id="ref-cit0001">1</a>,<a href="https://www.dovepress.com/articles.php?article_id=91190#cit0002" id="ref-cit0002">2</a></sup>
Despite significant advancements in microsurgical techniques in recent
years, effectively addressing nerve defects remains a formidable
challenge. While autografts have stood as the gold standard for nerve
defect repair, they are plagued by issues like donor nerve scarcity,
secondary trauma, and neuroma formation.<sup><a href="https://www.dovepress.com/articles.php?article_id=91190#cit0003" id="ref-cit0003">3</a></sup>
In recent years, artificial nerve conduits, including NeuroTube,
NeuraGen, NeuroMatrix, and others, have been developed as an alternative
approach.<sup><a href="https://www.dovepress.com/articles.php?article_id=91190#cit0004" id="ref-cit0004">4</a></sup>
However, these commercial conduits have shown suboptimal nerve
regeneration and functional recovery due to their basic tubular design
that offers only general guidance.<sup><a href="https://www.dovepress.com/articles.php?article_id=91190#cit0005" id="ref-cit0005">5</a>,<a href="https://www.dovepress.com/articles.php?article_id=91190#cit0006" id="ref-cit0006">6</a></sup>
Consequently, there is a pressing need for innovative solutions with
enhanced effectiveness for nerve repair in clinical scenarios.</p>
<p>It is now understood that following peripheral nervous system (PNS)
injuries, the distal nerve stump undergoes Wallerian degeneration and
forms aligned Büngner bands, facilitating and promoting axon growth.
Inspired by the organized structures of the PNS, longitudinal
microstructures such as aligned fibers, microgrooves, and microchannels
have been introduced into nerve guidance scaffolds (NGSs) using various
methods like electrospinning, phase separation, microstereolithography,
template thermo-crosslinking, and mold freeze-drying.<sup><a href="https://www.dovepress.com/articles.php?article_id=91190#cit0007 cit0008 cit0009 cit0010 cit0011" id="ref-cit0007 cit0008 cit0009 cit0010 cit0011">7–11</a></sup>
Electrospinning offers numerous advantages, including ease of use,
customizable scaffold structure, adjustable fiber diameter, and
suitability for various materials. State-of-the-art techniques have
enabled the production of highly aligned fibers that mimic tissue
structures, thereby improving regeneration.<sup><a href="https://www.dovepress.com/articles.php?article_id=91190#cit0012" id="ref-cit0012">12</a>,<a href="https://www.dovepress.com/articles.php?article_id=91190#cit0013" id="ref-cit0013">13</a></sup>
For instance, Wang et al demonstrated that highly aligned electrospun
poly-L-lactic acid (PLLA) fibers with appropriate diameters encouraged
neurite extension and Schwann cell (SC) migration.<sup><a href="https://www.dovepress.com/articles.php?article_id=91190#cit0014" id="ref-cit0014">14</a></sup>
Besides, Zhang et al reported that aligned nanofibers offered optimal
topographical cues for guiding cell and neurite growth in specific
orientations.<sup><a href="https://www.dovepress.com/articles.php?article_id=91190#cit0015" id="ref-cit0015">15</a></sup></p>
<p>Beyond topographical cues defined by the scaffold’s microstructure,
the significance of electroactive functional materials has gained
prominence.<sup><a href="https://www.dovepress.com/articles.php?article_id=91190#cit0016 cit0017 cit0018" id="ref-cit0016 cit0017 cit0018">16–18</a></sup>
Among these conductive materials, graphene oxide (GO) stands out due to
its exceptional electrical conductivity, biocompatibility, and
favorable interactions with cell interfaces. The negative carboxylate
groups on GO enhance colloidal stability and hydrophilicity, making it
suitable for surface attachment, proliferation, and differentiation of
nerve cells.<sup><a href="https://www.dovepress.com/articles.php?article_id=91190#cit0019" id="ref-cit0019">19</a></sup> Li et al demonstrated that GO significantly stimulates neural cell proliferation and differentiation.<sup><a href="https://www.dovepress.com/articles.php?article_id=91190#cit0020" id="ref-cit0020">20</a></sup>
Importantly, SCs exhibited improved adhesion, proliferation, and
neurotrophic factor secretion on GO-based substrates. GO has also been
shown to enhance neuro-specific gene expression, neurite outgrowth, and
sprouting in neuronal-like cells.<sup><a href="https://www.dovepress.com/articles.php?article_id=91190#cit0021" id="ref-cit0021">21</a></sup></p>
<p>Recently, a significant amount of effort has been taken in developing
nerve scaffolds with oriented microstructures and electroactive GO to
promote nerve regeneration. Most of these strategies have successfully
coated GO onto 2D surfaces. However, the coated GO is easy to detach
from the 2D surfaces. Thus, it is challenging to translate them into 3D
implantable scaffolds for clinical use.<sup><a href="https://www.dovepress.com/articles.php?article_id=91190#cit0015" id="ref-cit0015">15</a>,<a href="https://www.dovepress.com/articles.php?article_id=91190#cit0022" id="ref-cit0022">22</a></sup>
Furthermore, most of these studies have just investigated the effect of
oriented microstructures and electroactive GO on nerve regeneration
using cell lines (such as PC12 and RSC96) in vitro. Notably, the cell
lines are tumor-like cells, which show different biological
characteristics compared with primary cells and in vivo situations.
Moreover, the mechanisms underlying the synergistic impact of
electroactive GO and oriented topographic guidance on nerve regeneration
remains largely unexplored. Thus, for potential clinical applications,
it is imperative to adopt a more straightforward approach to fabricate
nerve scaffolds with electroactive GO and oriented microstructures
topography, assess the therapeutic effect of the scaffolds using primary
cell cultures and in vivo animal models, and comprehend the underlying
mechanisms.</p>
<p>In the present study, we employed a straightforward technique to
co-spin polycaprolactone (PCL) and GO, resulting in an oriented GO/PCL
hybrid nanofibrous scaffold termed the O-GO/PCL scaffold. The physical
and chemical properties of nanofibrous scaffold were tested by scanning
electron microscopy (SEM), transmission electron microscope (TEM),
tensile properties, 4-point probe method, Fourier transform infrared
(FTIR), and contact angle analysis. The impact of these developed
scaffolds on the biological properties and behavior of neural cells was
examined through co-culturing with primary SCs and dorsal root ganglia
(DRG) in vitro. Transcriptome sequencing (mRNA-seq) was employed to
probe the underlying mechanisms of the synergistic effect of
electroactive GO and longitudinal topographic guidance on nerve
regeneration. Furthermore, the developed O-GO/PCL NGS was utilized to
bridge a 10 mm sciatic nerve defect in rats, aiming to investigate its
therapeutic potential for peripheral nerve regeneration in vivo.</p></div>oc1deanhttp://www.blogger.com/profile/02302555382262295577noreply@blogger.com0tag:blogger.com,1999:blog-151811238595694978.post-28957017443205784162024-03-15T18:43:00.003-04:002024-03-15T18:43:29.469-04:00Launch of a state-of-the-art stroke rehabilitation hub in NHS Lanarkshire<h3 style="text-align: left;"> Still pretty worthless; 'guidelines' <span style="color: red;"><span style="font-size: large;">NOT PROTOCOLS!</span></span><br /></h3><h3 class="entry-title" style="text-align: left;"><u><a href="https://gcuocc.wordpress.com/2024/03/13/launch-of-a-state-of-the-art-stroke-rehabilitation-hub-in-nhs-lanarkshire/" target="_blank">Launch of a state-of-the-art stroke rehabilitation hub in NHS Lanarkshire</a></u></h3><h2 class="wp-block-heading">Current state of play</h2>
<p>Recently published Stroke rehabilitation <b><span style="color: #ff00fe;">guidelines</span></b> recommend
delivery of three hours of rehabilitation per day to optimise motor
recovery post stroke<sup>1</sup>. However, the amount of stroke rehabilitation currently delivered is well below this recommended amount<sup>2</sup>.
Addressing this rehabilitation shortfall is critical to ensure stroke
survivors are supported to reach their optimum levels of recovery. </p>
<h2 class="wp-block-heading">Technology-enriched rehabilitation</h2>
<p>Led by Dr Andy Kerr and Professor Philip Rowe in the Department of
Biomechanical Engineering, the University of Strathclyde have developed
an innovative programme of research investigating the feasibility of
employing ‘Technology-Enriched Rehabilitation Hubs’ (TERHS) to enable
stroke survivors to access the rehabilitation they need at the frequency
they require. </p>
<h2 class="wp-block-heading">State of the art stroke rehabilitation hub in NHS Lanarkshire</h2>
<figure class="wp-block-image size-large"><img alt="" class="wp-image-4025" data-attachment-id="4025" data-comments-opened="1" data-image-caption="" data-image-description="" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="image-3" data-large-file="https://gcuocc.files.wordpress.com/2024/02/image-3.png?w=525" data-medium-file="https://gcuocc.files.wordpress.com/2024/02/image-3.png?w=300" data-orig-file="https://gcuocc.files.wordpress.com/2024/02/image-3.png" data-orig-size="1024,660" data-permalink="https://gcuocc.wordpress.com/2024/03/13/launch-of-a-state-of-the-art-stroke-rehabilitation-hub-in-nhs-lanarkshire/image-3-4/" height="258" src="https://gcuocc.files.wordpress.com/2024/02/image-3.png?w=1024" width="400" /><figcaption class="wp-element-caption">Image used with thanks to University of Strathclyde</figcaption></figure>
<p>In partnership with NHS Lanarkshire, the team have launched a
state-of-the-art Technology Enriched Rehabilitation Hub at the stroke
unit at University Hospital Wishaw. The Hub is equipped with, “a range
of integrated technology, including virtual reality treadmills,
power-assisted equipment, balance trainers and upper limb training
systems. The technology also incorporates ‘gamification’, such as
virtual reality, puzzles and problem-solving activities, which helps to
enrich the environment and improves the engagement with and response to
therapy”<sup>3</sup>.</p>
<p>Led by<a href="https://twitter.com/AndyKerrBME" rel="noreferrer noopener" target="_blank"> Dr Andy Kerr </a>and <a href="https://twitter.com/GillianMSweeney" rel="noreferrer noopener" target="_blank">Dr Gillian Sweeney</a> (Advanced Practice Occupational Therapist, NHS Lanarkshire) and supported by funding from <a href="https://twitter.com/CHSScotland" rel="noreferrer noopener" target="_blank">Chest, Heart and Stroke Scotland</a>,
a research project is underway to investigate the impact of the Hub on
levels of rehabilitation provided and stroke survivor recovery. </p>
<figure class="wp-block-pullquote"><blockquote><p>“Due to limited
resources, NHS services are currently unable to provide recommended
levels of rehabilitation to people following a stroke. This innovative
model offers a way of providing higher intensity of rehabilitation out
with the traditional one to one therapy. Participants often report
benefits to group-based therapy, which they feel can offer peer support
and increase motivation.”</p><cite>Gillian Sweeney</cite></blockquote></figure><h3 class="entry-title" style="text-align: left;"></h3>oc1deanhttp://www.blogger.com/profile/02302555382262295577noreply@blogger.com0tag:blogger.com,1999:blog-151811238595694978.post-15414871721749747452024-03-15T18:42:00.002-04:002024-03-15T18:42:30.283-04:00Implementation and Evaluation of a Motivational Robotic Coach for Repetitive Stroke Rehabilitation<h3 style="text-align: left;">You don't understand <span style="color: red;">ONE GODDAMN THING ABOUT SURVIVOR MOTIVATION, DO YOU?</span>
You create 100% recovery protocols and your survivor will be motivated
to do the millions of reps needed because they are looking forward to
100% recovery. <span style="color: red;"><span style="font-size: x-large;">GET THERE!</span><span style="font-size: medium;"> </span></span></h3><h3 style="text-align: left;">The problem is stroke researchers are not motivated to solve stroke. What the fuck is your solution to that failure? <span style="color: red;">We still don't know how to motivate stroke medical 'professionals' to solve stroke to 100% recovery! </span></h3><h3 style="text-align: left;"><u> </u></h3><h3 style="text-align: left;"><u><a href="https://dl.acm.org/doi/pdf/10.1145/3610978.3640646" target="_blank">Implementation and Evaluation of a Motivational Robotic Coach for Repetitive Stroke Rehabilitation </a></u></h3><div style="text-align: left;"><br />Martin K. Ross<br />School of Mathematical and<br />Computer Sciences<br />Heriot-Watt University<br />Edinburgh, United Kingdom<br />mkr30@hw.ac.uk<br /> </div><div style="text-align: left;">Frank Broz<br />Intelligent Systems<br />Delft University of Technology<br />Delft, Netherlands<br />f.broz@tudelft.nl<br /> </div><div style="text-align: left;">Lynne Baillie<br />School of Mathematical and<br />Computer Sciences<br />Heriot-Watt University<br />Edinburgh, United Kingdom<br />l.baillie@hw.ac.uk<br /><h3 style="text-align: left;">ABSTRACT</h3>Repetitive, individual exercises can improve the functional ability<br />of stroke survivors over the long term. With the aim of providing<br />extra motivation to adhere to repetitive, individual rehabilitation,<br />this paper presents a robotic coach for stroke rehabilitation. Our<br />system uses the Pepper robot and performs one of twelve data-<br />driven coaching policies. The policies were learned from human-<br />human observations of professional stroke physiotherapists and<br />provide high-level personalisation based on user information and<br />training context. A within subjects evaluation of the system was<br />conducted in-person involving short interactions with 3 stroke<br />survivors. The system was able to engage the target end users and<br />there were indications that decreased workload could be possible<br />when using the system compared to exercising alone.<br /></div>oc1deanhttp://www.blogger.com/profile/02302555382262295577noreply@blogger.com0tag:blogger.com,1999:blog-151811238595694978.post-75166218088714117702024-03-15T18:26:00.005-04:002024-03-15T18:26:58.155-04:00Study Suggests During Sleep, Neural Process Helps Clear the Brain of Damaging Waste<h3 style="text-align: left;">This one doesn't suggest side sleeping, but others do. So go ask your competent? doctor what to do. Your doctor should be able to tell you how to know if this brain clearing is working properly.<br /></h3><h3 style="text-align: left;">But your doctor should give you this
information and the risk of stroke study and you can decide which is
more important to you. <br /></h3><ul style="text-align: left;"><li><h3>
<a dir="ltr" href="https://oc1dean.blogspot.com/search/label/side%20sleeping"><u>side sleeping</u></a>
<span dir="ltr">(5 posts to February 2017)</span>
</h3></li></ul><h3><a href="https://oc1dean.blogspot.com/2017/02/jfk-johnson-rehabilitation-suggests.html"><u>JFK Johnson Rehabilitation suggests that side sleeping may increase risk of stroke</u></a></h3><p> </p><h3 class="single-page-title" style="text-align: left;"><u>Study Suggests During Sleep, Neural Process Helps Clear the Brain of Damaging Waste</u></h3><div class="single-page-title" style="text-align: left;"><h1 class="single-page-title"><br /></h1>
<p>
<span>Posted on <time datetime="2024-03-14T10:36:42-04:00" pubdate="">March 14th, 2024</time> by <a href="https://directorsblog.nih.gov/author/dr-monica-m-bertagnolli/">Dr. Monica M. Bertagnolli</a></span></p><p>Te video is at the link. <span class="pull-right"></span>
</p>
<figure class="wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio"><div class="wp-block-embed__wrapper">
<span class="embed-youtube" style="display: block; text-align: center;"></span>
</div><figcaption class="wp-element-caption"><em>Artist’s rendering of neural activity clearing waste products through tight spaces of the brain. Credit: Donny Bliss/NIH</em></figcaption></figure>
<p>We’ve long known that sleep is a restorative process necessary for
good health. Research has also shown that the accumulation of waste
products in the brain is a leading cause of numerous neurological
disorders, including <a href="https://www.nia.nih.gov/health/alzheimers-and-dementia/alzheimers-disease-fact-sheet" rel="noreferrer noopener" target="_blank">Alzheimer’s</a> and <a href="https://www.ninds.nih.gov/health-information/disorders/parkinsons-disease" rel="noreferrer noopener" target="_blank">Parkinson’s</a> diseases. What hasn’t been clear is how the healthy brain “self-cleans,” or flushes out that detrimental waste.</p>
<p>But a new study by a research team supported in part by NIH suggests
that a neural process that happens while we sleep helps cleanse the
brain, leading us to wake up feeling rested and restored. Better
understanding this process could one day lead to methods that help
people function well on less sleep. It could also help researchers find
potential ways to delay or prevent neurological diseases related to
accumulated waste products in the brain.</p>
<p>The findings, reported in <a href="https://pubmed.ncbi.nlm.nih.gov/38418877/" rel="noreferrer noopener" target="_blank"><em>Nature</em></a>,
show that, during sleep, neural networks in the brain act like an array
of miniature pumps, producing large and rhythmic waves through
synchronous bursts of activity that propel fluids through brain tissue.
Much like the process of washing dishes, where you use a rhythmic motion
of varying speeds and intensity to clear off debris, this process that
takes place during sleep clears accumulated metabolic waste products
out.</p>
<p>The research team, led by <a href="https://kipnislab.wustl.edu/" rel="noreferrer noopener" target="_blank">Jonathan Kipnis</a> <a href="https://www.nih.gov/web-policies-notices"><span aria-hidden="true" class="glyphicon glyphicon-new-window"></span></a>
and Li-Feng Jiang-Xie at Washington University School of Medicine in
St. Louis, wanted to better understand how the brain manages its waste.
This is not an easy task, given that the human brain’s billions of
neurons inevitably produce plenty of junk during cognitive processes
that allow us to think, feel, move, and solve problems. Those waste
products also build in a complex environment, including a packed maze of
interconnected neurons, blood vessels, and interstitial spaces,
surrounded by a protective blood-brain barrier that limits movement of
substances in or out.</p>
<p>So, how does the brain move fluid through those tight spaces with the
force required to get waste out? Earlier research suggested that neural
activity during sleep might play an important role in those
waste-clearing dynamics. But previous studies hadn’t pinned down the way
this works.</p>
<p>To learn more in the new study, the researchers recorded brain
activity in mice. They also used an ultrathin silicon probe to measure
fluid dynamics in the brain’s interstitial spaces. In awake mice, they
saw irregular neural activity and only minor fluctuations in the
interstitial spaces. But when the animals were resting under anesthesia,
the researchers saw a big change. Brain recordings showed strongly
enhanced neural activity, with two distinct but tightly coupled rhythms.
The research team realized that the structured wave patterns could
generate strong energy that could move small molecules and peptides, or
waste products, through the tight spaces within brain tissue.</p>
<p>To make sure that the fluid dynamics were really driven by neurons,
the researchers used tools that allowed them to turn neural activity off
in some areas. Those experiments showed that, when neurons stopped
firing, the waves also stopped. They went on to show similar dynamics
during natural sleep in the animals and confirmed that disrupting these
neuron-driven fluid dynamics impaired the brain’s ability to clear out
waste.</p>
<p>These findings highlight the importance of this cleansing process
during sleep for brain health. The researchers now want to better
understand how specific patterns and variations in those brain waves
lead to changes in fluid movement and waste clearance. This could help
researchers eventually find ways to speed up the removal of damaging
waste, potentially preventing or delaying certain neurological diseases
and allowing people to need less sleep.</p>
<p>Reference:</p>
<p>[1] Jiang-Xie LF, <em>et al</em>. <a href="https://pubmed.ncbi.nlm.nih.gov/38418877/" rel="noreferrer noopener" target="_blank">Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance</a>. <em>Nature</em>. DOI: 10.1038/s41586-024-07108-6 (2024).</p>
<p><em>NIH Support: National Center for Complementary and Integrative Health</em></p></div>oc1deanhttp://www.blogger.com/profile/02302555382262295577noreply@blogger.com0tag:blogger.com,1999:blog-151811238595694978.post-12968241473574465812024-03-15T18:07:00.000-04:002024-03-15T18:07:58.441-04:00Pneumatic robotic glove aids training for stroke and hand disability rehabilitation<h3 style="text-align: left;">At least with the cutout palm area spastic fingers could get it on. But which glove is your doctor and therapists already using for your recovery? <span style="color: red;"><span style="font-size: x-large;">NONE?</span></span> I guess you don't have a functioning stroke doctor or hospital!</h3><h3 style="text-align: left;"> Hopefully your competent? doctor has already tested out these others and found the best one for recovery</h3><h3 style="text-align: left;">Many gloves out there. Which is the best? Your doctor better know the answer.<br /></h3><ul style="text-align: left;"><li><h3>
<a dir="ltr" href="http://oc1dean.blogspot.com/search/label/FES-Robotic%20Glove"><u>FES-Robotic Glove</u></a>
<span dir="ltr">(1)</span></h3></li><li><h3>
<a dir="ltr" href="http://oc1dean.blogspot.com/search/label/Gyroscopic%20glove"><u>Gyroscopic glove</u></a>
<span dir="ltr">(1)</span>
</h3></li><li><h3>
<a dir="ltr" href="http://oc1dean.blogspot.com/search/label/HERO%20Grip%20Glove"><u>HERO Grip Glove</u></a>
<span dir="ltr">(1)</span>
</h3></li><li><h3>
<a dir="ltr" href="http://oc1dean.blogspot.com/search/label/music%20glove"><u>music glove</u></a>
<span dir="ltr">(1)</span>
</h3></li><li><h3>
<a dir="ltr" href="http://oc1dean.blogspot.com/search/label/RAPAEL%20Smart%20Glove"><u>RAPAEL Smart Glove</u></a>
<span dir="ltr">(5)</span>
</h3></li><li><h3>
<a dir="ltr" href="http://oc1dean.blogspot.com/search/label/SaeboGlove"><u>SaeboGlove</u></a>
<span dir="ltr">(1)</span></h3></li><li><h3>
<a dir="ltr" href="http://oc1dean.blogspot.com/search/label/VTS%20Glove"><u>VTS Glove</u></a>
<span dir="ltr">(1)</span>
</h3></li><li><h3>
<a dir="ltr" href="http://oc1dean.blogspot.com/search/label/EsoGlove"><u>EsoGlove</u></a>
<span dir="ltr">(1)</span></h3></li></ul><h3 style="text-align: left;"> </h3><h3>
<a dir="ltr" href="http://oc1dean.blogspot.com/search/label/glove"><u>glove</u></a>
<span dir="ltr">(89 posts to October 2011)</span></h3><ul><li><h3>
<a dir="ltr" href="http://oc1dean.blogspot.com/search/label/gloves"><u>gloves</u></a>
<span dir="ltr">(5 posts to December 2021)</span>
</h3></li></ul><h3 style="text-align: left;"> </h3><h3 style="text-align: left;">I hated the Saebo-flex glove I got, the bead chains were impossible to adjust one-handed and the thumb couldn't get positioned properly. Saebo told me their glove was meant to be adjusted by a therapist, I totally disagree with that stance.<br /></h3><h3 class="m-pad post-title-inner" style="text-align: left;"><br /></h3><h3 class="m-pad post-title-inner" style="text-align: left;"><u><a href="https://www.designboom.com/design/pneumatic-robotic-glove-rehabilitation-stroke-hand-disability-recovery-idc-xft-medial-03-15-2024/" target="_blank">Pneumatic robotic glove aids training for stroke and hand disability rehabilitation</a></u></h3><div class="m-pad post-title-inner" style="text-align: left;"><p>XFT Medical and IDC present the Hand Rehabilitation Glove — a
training device designed to aid patients recovering from strokes or hand
disabilities. The neoprene glove combines EMG feedback and flexible
robotics for patients to support in training and repairing dexterity.
Using flexible air-activated muscles to aid movement, the robotic glove
targets limb motor function and prevents muscle disuse atrophy, enabling
patients to carry out passive rehabilitation training through pre-set
training programs.</p><p> </p><p>Featuring six distinct training modes,
including power-assisted movement and resistance training, the glove
offers a versatile approach to muscle strengthening. Users can complete
specific training programs tailored for full hand movement, fingertip
touch training, and single finger exercises, promoting both gross and
fine motor skill improvement. With size options available in small,
medium, and large, the glove ensures a comfortable fit for all, while
its adjustable air pressure mechanism enables personalized strength
settings, catering to individual rehabilitation needs.</p><p><img alt="pneumatic robotic glove aids training for stroke and hand disability rehabilitation" class="lazyload" data-src="https://static.designboom.com/wp-content/dbsub/454983/2024-03-08/rehabilitation-glove-for-xft-medical-9-65eaf46ebac7c.jpg" height="225" src="https://static.designboom.com/wp-content/dbsub/454983/2024-03-08/rehabilitation-glove-for-xft-medical-9-65eaf46ebac7c.jpg" width="400" /> </p><p>all images courtesy of IDC</p><p> </p><p> </p><h2 class="wow wow-yellow">the training device accelerates repairing hand dexterity</h2><p><b> </b></p><p>XFT
Medical has had a long-standing partnership with IDC to develop a range
of medical and rehabilitation devices. Their Hand Rehabilitation Glove,
alongside an EMG armband and control unit aligned with XFT’s existing
home medical line up, work together united by a cohesive brand identity.
Integrating innovative mirror technology, the armband enables
synchronous movement between unaffected between affected and unaffected
hands, aiding autonomous brain recovery and accelerating the
rehabilitation process.</p><p> </p><p>For the robotic glove, IDC
followed an empathetic design process to understand and address the
specific requirements of users, many of whom are affected by reduce
dexterity and lack caregiver assistance to help use the product. <a href="https://www.idc.uk.com/" rel="noopener" target="_blank"><b>The team</b></a>
recognized that the device must be simple to use, easy to put on using
only one hand, leading to the design’s cut-out palm area, fingertip
hoods, and supportive wrist strap. Testing was conducted to optimize the
balance between functionality, treatment effectiveness, and user
experience, and neoprene was eventually selected for its washability,
strength, and comfort. From user testing, IDC found that often the
patients had weak wrists making it hard to complete the training,
prompting the integration of a wrist strap to enhance usability and
treatment effectiveness.</p><p><img alt="pneumatic robotic glove aids training for stroke and hand disability rehabilitation" class="wp-image-1053522 size-full lazyload" data-sizes="auto" data-src="https://static.designboom.com/wp-content/uploads/2024/03/rehabilitation-glove-idc-team-designboom-11.jpg" data-srcset="https://static.designboom.com/wp-content/uploads/2024/03/rehabilitation-glove-idc-team-designboom-11.jpg 818w, https://static.designboom.com/wp-content/uploads/2024/03/rehabilitation-glove-idc-team-designboom-11-768x526.jpg 768w" height="274" src="https://static.designboom.com/wp-content/uploads/2024/03/rehabilitation-glove-idc-team-designboom-11.jpg" width="400" /> </p><p>XFT Medical and IDC present the Hand Rehabilitation Glove</p><p> </p><p><b> </b></p><h2 class="wow wow-yellow">the glove’s neoprene form integrates advanced engineering</h2><p> </p><p>Competitor
research revealed key issues with existing offerings, with bulky
solutions which didn’t grant enough flexibility and mobility. Using
IDC’s in-house prototyping capabilities, different solutions for the
glove were tested and optimized, finding that rounded bellows expand
more effectively. While initial concepts aimed for a custom integrated
bellow to give the product a sleek, unified look, manufacturability
constraints and cost analysis led to the adoption of proven bellows with
refined junctions for a cleaner design. There was also a focus on clean
and unobtrusive airway management to power the bellows from the control
unit.</p><div data-adnz-effect-tag="ad:adnz_infeed_1" data-adnz-placement="1" id="adnz_infeed_1"></div><p></p><p><img alt="pneumatic robotic glove aids training for stroke and hand disability rehabilitation" class="wp-image-1053530 size-full lazyload" data-sizes="auto" data-src="https://static.designboom.com/wp-content/uploads/2024/03/rehabilitation-glove-idc-team-designboom-16.jpg" data-srcset="https://static.designboom.com/wp-content/uploads/2024/03/rehabilitation-glove-idc-team-designboom-16.jpg 818w, https://static.designboom.com/wp-content/uploads/2024/03/rehabilitation-glove-idc-team-designboom-16-768x432.jpg 768w" height="225" src="https://static.designboom.com/wp-content/uploads/2024/03/rehabilitation-glove-idc-team-designboom-16.jpg" width="400" /> </p><p>the design features a cut-out palm area, fingertip hoods, and supportive wrist strap</p><p> </p><p> </p></div><div class="m-pad post-title-inner" style="text-align: left;"><p></p><p></p><p></p><p></p><p></p><p></p><p><img alt="pneumatic robotic glove aids training for stroke and hand disability rehabilitation" class="lazyload" data-src="https://static.designboom.com/wp-content/dbsub/454983/2024-03-08/rehabilitation-glove-for-xft-medical-3-65eaf46ebaba9.jpg" height="180" src="https://static.designboom.com/wp-content/dbsub/454983/2024-03-08/rehabilitation-glove-for-xft-medical-3-65eaf46ebaba9.jpg" width="320" /></p><p> </p><p>the robotic glove functions alongside an EMG armband and control unit</p><p><img alt="pneumatic robotic glove aids training for stroke and hand disability rehabilitation" class="lazyload" data-src="https://static.designboom.com/wp-content/dbsub/454983/2024-03-08/rehabilitation-glove-for-xft-medical-4-65eaf46ebabd3.jpg" height="225" src="https://static.designboom.com/wp-content/dbsub/454983/2024-03-08/rehabilitation-glove-for-xft-medical-4-65eaf46ebabd3.jpg" width="400" /> </p><p> </p><p>the training devices are designed to aid patients recovering from strokes or hand disabilities</p><p><img alt="IDC" class="lazyload" data-src="https://static.designboom.com/wp-content/dbsub/454983/2024-03-08/rehabilitation-glove-for-xft-medical-5-65eaf46ebabf9.jpg" height="225" src="https://static.designboom.com/wp-content/dbsub/454983/2024-03-08/rehabilitation-glove-for-xft-medical-5-65eaf46ebabf9.jpg" width="400" /> </p><p> </p><p>training programs promote both gross and fine motor skill improvement</p><p><img alt="IDC" class="lazyload" data-src="https://static.designboom.com/wp-content/dbsub/454983/2024-03-08/rehabilitation-glove-for-xft-medical-8-65eaf46ebac5b.jpg" height="225" src="https://static.designboom.com/wp-content/dbsub/454983/2024-03-08/rehabilitation-glove-for-xft-medical-8-65eaf46ebac5b.jpg" width="400" /> </p><p> </p><p>the armband enables synchronous movement between unaffected between affected and unaffected hands</p><p><img alt="IDC" class="lazyload" data-src="https://static.designboom.com/wp-content/dbsub/454983/2024-03-08/rehabilitation-glove-for-xft-medical-6-65eaf46ebac1b.jpg" height="225" src="https://static.designboom.com/wp-content/dbsub/454983/2024-03-08/rehabilitation-glove-for-xft-medical-6-65eaf46ebac1b.jpg" width="400" /> </p><p> </p><p>testing optimized the balance between functionality, treatment effectiveness, and user experience</p><p><img alt="pneumatic robotic glove aids training for stroke and hand disability rehabilitation" class="wp-image-1053528 size-full lazyload" data-sizes="auto" data-src="https://static.designboom.com/wp-content/uploads/2024/03/rehabilitation-glove-idc-team-designboom-13-1.jpg" data-srcset="https://static.designboom.com/wp-content/uploads/2024/03/rehabilitation-glove-idc-team-designboom-13-1.jpg 818w, https://static.designboom.com/wp-content/uploads/2024/03/rehabilitation-glove-idc-team-designboom-13-1-768x468.jpg 768w" height="244" src="https://static.designboom.com/wp-content/uploads/2024/03/rehabilitation-glove-idc-team-designboom-13-1.jpg" width="400" /> </p><p>the glove targets limb motor function and prevents muscle disuse atrophy</p><p><img alt="pneumatic robotic glove aids training for stroke and hand disability rehabilitation" class="wp-image-1053527 size-full lazyload" data-sizes="auto" data-src="https://static.designboom.com/wp-content/uploads/2024/03/rehabilitation-glove-idc-team-designboom-12-1.jpg" data-srcset="https://static.designboom.com/wp-content/uploads/2024/03/rehabilitation-glove-idc-team-designboom-12-1.jpg 818w, https://static.designboom.com/wp-content/uploads/2024/03/rehabilitation-glove-idc-team-designboom-12-1-768x468.jpg 768w" height="244" src="https://static.designboom.com/wp-content/uploads/2024/03/rehabilitation-glove-idc-team-designboom-12-1.jpg" width="400" /> </p><p> </p><p>there was a focus on clean and unobtrusive airway management to power the bellows from the control unit</p><p><img alt="pneumatic robotic glove aids training for stroke and hand disability rehabilitation" class="wp-image-1053529 size-full lazyload" data-sizes="auto" data-src="https://static.designboom.com/wp-content/uploads/2024/03/rehabilitation-glove-idc-team-designboom-15-1.jpg" data-srcset="https://static.designboom.com/wp-content/uploads/2024/03/rehabilitation-glove-idc-team-designboom-15-1.jpg 818w, https://static.designboom.com/wp-content/uploads/2024/03/rehabilitation-glove-idc-team-designboom-15-1-768x468.jpg 768w" height="244" src="https://static.designboom.com/wp-content/uploads/2024/03/rehabilitation-glove-idc-team-designboom-15-1.jpg" width="400" /> </p><p> </p><p>the neoprene glove combines EMG electromyographic feedback and flexible robotics</p><p><img alt="pneumatic robotic glove aids training for stroke and hand disability rehabilitation" class="lazyload" data-src="https://static.designboom.com/wp-content/dbsub/454983/2024-03-08/rehabilitation-glove-for-xft-medical-1-65eaf46ebab15.jpg" height="225" src="https://static.designboom.com/wp-content/dbsub/454983/2024-03-08/rehabilitation-glove-for-xft-medical-1-65eaf46ebab15.jpg" width="400" /> </p><p>design process</p><div class="fullwidth-image"> <img alt="rehabilitation-glove-idc-team-designboom-1" class="lazyload" data-src="https://static.designboom.com/wp-content/uploads/2024/03/rehabilitation-glove-idc-team-designboom-1-1.jpg" height="200" src="https://static.designboom.com/wp-content/uploads/2024/03/rehabilitation-glove-idc-team-designboom-1-1.jpg" width="400" /></div><div class="box-sidebar"><div class="page-content"><article class="post-content"><p> </p><p> </p><p><b>project info:</b></p><p> </p><p><b>name:</b> Rehabilitation Glove<br /> <b>designer:</b> <a href="https://www.idc.uk.com/" rel="noopener noreferrer" target="_blank">IDC</a></p><p> </p><p><i>designboom has received this project from our </i><a href="https://www.designboom.com/readers-submit"><i>DIY submissions</i></a><i> feature, where we welcome our readers to submit their own work for publication. see more project submissions from our readers </i><a href="https://www.designboom.com/readers/"><i>here.</i></a></p><p> </p><p><i>edited by: ravail khan | designboom</i></p></article><div class="post-author-box"><div class="post-author bck-half bck-half-yellow no-hover">IDC</div><div class="post-date exclude-small bck-half bck-half-yellow no-hover">mar 15, 2024</div></div></div></div><br /><div class="box-sidebar"><div class="page-content"><article class="post-content"></article></div></div><div class="open" id="db-cookie-notice"><div class="db-cn-hero"></div></div></div>oc1deanhttp://www.blogger.com/profile/02302555382262295577noreply@blogger.com0tag:blogger.com,1999:blog-151811238595694978.post-63345370959256010662024-03-14T23:54:00.000-04:002024-03-14T23:54:28.472-04:00Webinar: Quality Improvement in Stroke Care by Stroke Foundation, Australia<h3 style="text-align: left;">Sign up as a stroke survivor. Demand to know why 'care' is being discussed when survivors want 100% recovery!<br /></h3><h3 style="text-align: left;">Ask how to get to 100% recovery and <span style="color: red;">KEEP ASKING UNTIL IT IS ANSWERED! Do not accept ANY EXCUSES!</span> Or if you want to be politer; ask how they are going to 100% recover when they are the <b><span style="color: red;"><a href="http://oc1dean.blogspot.com/2018/12/one-in-four-people-will-have-stroke.html" target="_blank"><u>1 in 4 per WHO that has a stroke</u></a><u>.</u></span></b></h3><h3 style="text-align: left;"><b>I
totally suggest making them feel vastly uncomfortable about the lack of
recovery that the stroke world can provide! Throw some bombs, nothing
else will make the stroke world solve stroke!<u><br /></u></b></h3><h3 style="text-align: left;"></h3><h3 style="text-align: left;"><u><a href="https://strokefoundation.zoom.us/webinar/register/WN_c26xRoS1SwyHkxHWenvQMQ#/registration" target="_blank"> Webinar: Quality Improvement in Stroke Care by Stroke Foundation, Australia</a></u></h3><div class="zm-col zm-col-6" data-v-d509169a="">Date & Time</div><div class="pdl-xs zm-col zm-col-18" data-v-d509169a="">
Mar 25, 2024 11:00 PM in
</div><div class="mgb-md zm-row" data-v-d509169a=""><div class="zm-col zm-col-6" data-v-d509169a="">Description</div><div class="pdl-xs w-sp zm-col zm-col-18" data-v-d509169a="">What is Quality Improvement? How does it fit into the Learning Health System?
This webinar will explore how you can implement quality improvement, including practical tips and tools, as well as how to get buy-in from team members, managers, and executives.
Join Melita, Julie and Helen to learn more about using quality improvement in stroke <b><span style="color: #ff00fe;">care</span></b> effectively at your site.
</div></div><h3 style="text-align: left;"><br /></h3>oc1deanhttp://www.blogger.com/profile/02302555382262295577noreply@blogger.com0