Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Saturday, September 10, 2011

Restoring Capillary Blood Flow after a Stroke

Another hyperacute idea to be researched.
http://www.dana.org/news/brainwork/detail.aspx?id=23436

Clots that restrict the flow of blood to the brain cause ischemic stroke. Even after a clot is gone, about half of capillaries remain constricted—at least in mice—even though blood flow is restored in larger vessels. Researchers have found that free radicals in blood vessels lead to this constriction. That discovery may help pinpoint a new treatment target for ischemic stroke, the most common type.
“Since adequate oxygen supply is critically important to the brain tissue trying to recover from the ischemic episode, we decided to study what caused these constrictions and how it could be relieved,” says researcher Turgay Dalkara of Hacettepe University in Turkey. Their findings were published online Aug. 30 in Nature Medicine.
The investigators focused on pericytes. Located in capillary walls, these cells regulate capillary flow by contracting and relaxing. The researchers used high-powered microscopes to study mouse retinas, which have capillaries rich with pericytes. When they created ischemia-like conditions in the retinas, the pericytes remained contracted for hours after blood flow was restored in other vessels.
“Pericytes were not known to play such a negative but important role before,” says Dalkara. The researchers observed a similar effect in anesthetized mice after marking capillaries with molecules that glowed under the ultraviolet light of a fluorescence microscope.
The sustained pericyte constriction was caused by free radicals produced in blood vessel walls. “Oxygen and nitrogen radicals are very toxic,” Dalkara says. He notes that when blood flow is restored in vessels larger than capillaries, free radicals are produced in excess amounts.
The researchers addressed that problem by injecting the mice with chemicals that suppress the production of the free radicals. When they prevented that toxicity, the pericytes relaxed and allowed blood to flow through the capillaries.
After a stroke, that increased oxygen supply could be crucial for brain tissue survival. “We want to develop methods to study the problem in stroke patients with the available imaging technologies,” says Dalkara. “But it seems not an easy task.”

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