Randomized Placebo-Controlled Trial of Methylphenidate or Galantamine for Persistent Emotional and Cognitive Symptoms Associated with PTSD and/or Traumatic Brain Injury

Your doctor will need to create a followup study on this. Or a study sponsored by our fucking failures of stroke associations.

Randomized Placebo-Controlled Trial of Methylphenidate or Galantamine for Persistent Emotional and Cognitive Symptoms Associated with PTSD and/or Traumatic Brain Injury`

McAllister TW¹, Zafonte R², Jain S³, Flashman LA⁴, George MS⁵, Grant GA⁶, He F³, Lohr JB⁷, Andaluz N⁸, Summerall L⁹, Paulus MP¹⁰, Raman R³, Stein MB^11,12.

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Abstract

We report findings from a 12-week randomized double-blind placebo-controlled trial of methylphenidate or galantamine to treat emotional and cognitive complaints in individuals (N=32) with a history of PTSD, TBI, or both conditions. In this small pilot study, methylphenidate treatment was associated with clinically meaningful and statistically significant improvement compared to placebo on the primary outcome, a measure of cognitive complaints (Ruff Neurobehavioral Inventory - Postmorbid Cognitive Scale), as well as on the secondary outcomes reflecting postconcussive (Rivermead Postconcussive Symptom Questionnaire) and posttraumatic stress symptoms (Posttraumatic Stress Disorder Checklist). Treatment was well tolerated. These results suggest the need for a larger RCT to replicate and confirm these findings. Design considerations for such a trial should include the need for multiple sites to facilitate adequate recruitment and extension of the treatment and follow-up periods.Neuropsychopharmacology accepted article preview online, 11 September 2015. doi:10.1038/npp.2015.282.