Tuesday, July 30, 2024

The role of integrins in brain health and neurodegenerative diseases

 What will your competent? doctor do with this to get you recovered?

 Oh, NOTHING, LIKE USUAL?

The role of integrins in brain health and neurodege nerative diseases

https://doi.org/10.1016/j.ejcb.2024.151441
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Highlights

  • Integrins are pivotal receptors for brain development and function

  • Integrins also play a role in neurological diseases

  • Integrins are important therapeutical targets for inflammatory brain disorders

Abstract

Integrins are heterodimeric membrane proteins expressed on the surface of most cells. They mediate adhesion and signaling processes relevant for a wealth of physiological processes, including nervous system development and function. Interestingly, integrins are also recognized therapeutic targets for inflammatory diseases, such as multiple sclerosis. Here, we discuss the role of integrins in brain development and function, as well as in neurodegenerative diseases affecting the brain (Alzheimer’s disease, multiple sclerosis, stroke). Furthermore, we discuss therapeutic targeting of these adhesion receptors in inflammatory diseases of the brain.

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