Do you really think your competent? doctor can see the benefits for stroke rehab and contact stroke leadership to get human research done? NO? So you don't believe you have a functioning stroke doctor; do you? I don't care that there is NO stroke leadership anywhere! Your competent? doctor should band with other doctors to create a leadership structure. Otherwise stroke will never be solved with NO leadership or strategy! Which is why survivors should be in charge, we would get things done.
Wrapping stem cells with wireless electrical nanopatches for traumatic brain injury therapy
Nature Communications volume 15, Article number: 7223 (2024)
Abstract
Electrical stimulation holds promise for enhancing neuronal differentiation of neural stem cells to treat traumatic brain injury. However, once the stem cells leave the stimulating material and migrate post transplantation, electrical stimulation on them is diminished. Here, we wrap the stem cells with wireless electrical nanopatches, the conductive graphene nanosheets. Under electromagnetic induction, electrical stimulation can thus be applied in-situ to individual nanopatch-wrapped stem cells on demand, stimulating their neuronal differentiation through a MAPK/ERK signaling pathway. Consequently, 41% of the nanopatch-wrapped stem cells differentiate into functional neurons in 5 days, as opposed to only 16.3% of the unwrapped ones. The brain injury male mice implanted with the nanopatch-wrapped stem cells and exposed to a rotating magnetic field 30 min/day exhibit significant recovery of brain tissues, behaviors, and cognitions, within 28 days. This study opens up an avenue to individualized electrical stimulation of transplanted stem cells for treating neurodegenerative diseases.
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