Cerebrospinal fluid control of neurogenesis induced by retinoic acid during early brain development

More proof of the usefulness of CSF, I know it talks about early brain development but that just means someone has to research how to recreate that in the adult brain. I talked about this in an earlier post;
http://oc1dean.blogspot.com/2011/03/role-of-cerebrospinal-fluid-in-brain.html

The new article:
http://onlinelibrary.wiley.com/doi/10.1002/dvdy.22657/full
Keywords:CSF;brain development;retinol binding protein;neural precursors;neural tube;neurogenesis
Abstract
Embryonic-cerebrospinal fluid (E-CSF) plays crucial roles in early brain development including the control of neurogenesis. Although FGF2 and lipoproteins present in the E-CSF have previously been shown to be involved in neurogenesis, the main factor triggering this process remains unknown. E-CSF contains all-trans-retinol and retinol-binding protein involved in the synthesis of retinoic acid (RA), a neurogenesis inducer. In early chick embryo brain, only the mesencephalic-rombencephalic isthmus (IsO) is able to synthesize RA. Here we show that in chick embryo brain development: (1) E-CSF helps to control RA synthesis in the IsO by means of the RBP and all-trans-retinol it contains; (2) E-CSF has retinoic acid activity, which suggests it may act as a diffusion pathway for RA; and (3) the influence of E-CSF on embryonic brain neurogenesis is to a large extent due to its involvement in RA synthesis. These data help to understand neurogenesis from neural progenitor cells. Developmental Dynamics, 2011. © 2011 Wiley-Liss, Inc