Tell your researchers that this functionality should be able to map neurons as they try to connect to each other. Watching it in real time would be useful in telling what some of the neuroplasticity and neurogenesis therapies are doing. And once we know that we should be able to come up with specific therapies that work. Heck, we should be able to do this in the next 30 years.
http://nextbigfuture.com/2011/07/researchers-at-brigham-and-womens.html
The ability to explore cell signalling and cell-to-cell communication is essential for understanding cell biology and developing effective therapeutics. However, it is not yet possible to monitor the interaction of cells with their environments in real time. Here, we show that a fluorescent sensor attached to a cell membrane can detect signalling molecules in the cellular environment. The sensor is an aptamer (a short length of single-stranded DNA) that binds to platelet-derived growth factor (PDGF) and contains a pair of fluorescent dyes. When bound to PDGF, the aptamer changes conformation and the dyes come closer to each other, producing a signal. The sensor, which is covalently attached to the membranes of mesenchymal stem cells, can quantitatively detect with high spatial and temporal resolution PDGF that is added in cell culture medium or secreted by neighbouring cells. The engineered stem cells retain their ability to find their way to the bone marrow and can be monitored in vivo at the single-cell level using intravital microscopy.
13 more pages of detail here:
http://www.nature.com/nnano/journal/vaop/ncurrent/extref/nnano.2011.101-s1.pdf
Someone has to push this kind of stuff so contact your researcher and your stroke association and ask them what they are going to do with this information.
No comments:
Post a Comment