Monday, October 10, 2011

Wnt/ beta-catenin Signaling Is Active Post-stroke and Wnt-3a Liposomes Promote Neurogenesis and Functional Recovery Post-MCAO

More hyperacute possibilities, I did talk about liposomes earlier.
http://w3.cns.org/dp/2011CNS/1091.pdf
Wnt-3a liposomes, made and in vitro
t e s t e d i n t h e l a b , w e r e i n j e c t e d intraparenchymally at 2, 4 and 6 days post-
MCAO. Results (4)
-functional recovery was significantly
improved following repetitive Wnt-3a
liposomal administration post-stroke, as
determined by the horizontal ladder
behavior test at 4 weeks post-MCAO
(p<0.010, t-test, **). There was also a
trend of smaller infarct sizes in the Wnt-3a
injected cohort (data not shown)

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