Membrane Trafficking and Endothelial-Cell Dynamics During Angiogenesis

Only 28 pages and I learned something new, vasculogenesis vs angiogenesis, I wonder which is more applicable for us survivors that have lots of dead area. Cool diagrams in the pdf, sections listed, details at the link.
http://cdn.intechweb.org/pdfs/31164.pdf
1. Introduction
The formation of new blood vessels, or neovascularization, involves multiple processes,
including cell proliferation and migration, cell-cell and cell-matrix adhesion, and tube
morphogenesis. Neovascularization can occur through one of two events: vasculogenesis,
the de novo formation of blood vessels from angioblasts; or angiogenesis, the extension of
new vessels from a pre-existing vasculature. Among these, angiogenesis in particular is
relevant throughout life; its dysregulation has been causally related to several disorders that
involve malignancy, inflammation, and ischemia. Angiogenesis is thought to depend on a
set of signaling proteins – including certain kinases, integrins and vascular endothelial
growth factor receptor-2 (VEGFR2) – that are enriched in specific plasma membrane
domains. Both physiological and pathological angiogenesis rely on intracellular trafficking,
a process that governs signaling by such proteins, as well as cell motility.
In this chapter, we discuss our current understanding of angiogenesis from the perspective
of trafficking of the membrane components that are responsible for endothelial-cell (EC) dynamics.
2. Angiogenesis: Mechanism and importance

Fig. 1. Schematic representation of a mature blood vessel. Endothelial cells at the luminal
side line tubular blood vessel. The smooth muscle cells and the pericytes that remain in
contact with the endothelial cell lining through the basement membrane strengthen this
tubular structure.
2.1 Vasculogenesis
2.2 Angiogenesis
2.3 Pathological angiogenesis
3. Ligands and receptors in angiogenesis
3.1 The VEGF-VEGFR system coordinates the process of angiogenesis
3.1.1 VEGF
3.2 VEGF receptors
3.2.1 VEGFR1
3.2.2 VEGFR2
3.2.3 VEGFR3
3.2.4 Neuropilins (NRP)
3.3 Role of the extracellular matrix (ECM) in endothelial-cell interactions during angiogenesis
3.4 Role of Integrin in endothelial-cell dynamics during angiogenesis
4. Membrane trafficking
4.1 Biosynthetic/secretory pathway
4.2 Endocytic and exocytic pathways
4.3 Endocytic trafficking of VEGFR2
4.4 Secretory transport of VEGFR2
4.5 VEGFR2 trafficking and angiogenesis