Magnetically drivable, something I've been suggesting for years. Put tPA into nanoparticles and direct them to the clot, using much less drug with fewer side effects. The rest of the abstract is incomprehensible.
http://www.dovepress.com/articles.php?article_id=9806
Abstract: Novel superparamagnetic
surface-active maghemite nanoparticles (SAMNs) characterized by a
diameter of 10 ± 2 nm were modified with bovine serum amine oxidase,
which used rhodamine B isothiocyanate (RITC) adduct as a fluorescent
spacer-arm. A fluorescent and magnetically drivable adduct comprised of
bovine serum copper-containing amine oxidase (SAMN–RITC–BSAO) that
immobilized on the surface of specifically functionalized magnetic
nanoparticles was developed. The multifunctional nanomaterial was
characterized using transmission electron microscopy, infrared
spectroscopy, mass spectrometry, and activity measurements. The results
of this study demonstrated that bare magnetic nanoparticles form stable
colloidal suspensions in aqueous solutions. The maximum binding capacity
of bovine serum amine oxidase was approximately 6.4 mg g-1
nanoparticles. The immobilization procedure reduced the catalytic
activity of the native enzyme to 30% ± 10% and the Michaelis constant
was increased by a factor of 2. We suggest that the SAMN–RITC–BSAO
complex, characterized by a specific activity of 0.81 IU g-1, could be used in the presence of polyamines to create a fluorescent magnetically drivable H2O2 and aldehydes-producing system. Selective tumor cell destruction is suggested as a potential future application of this system.
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