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http://www.compmed.umm.edu/cochrane-reviews/cochrane-rev-stroke.asp
What the synthesised research says
One trial, which was well conducted to limit external influences on the results (biases), measured neurological deficit and did not show a clear benefit with Ginkgo biloba compared with non-active treatment (placebo). This places doubt on how beneficial Ginkgo biloba is.An improvement in neurological impairment was reported with Ginkgo biloba in nine
trials that had important methodological limitations. The review authors conclude that there is no clear evidence to support the routine use of Ginkgo biloba extract to promote recovery after stroke. High-quality and large-scale randomised controlled trials are needed to test its efficacy.
How it was tested
The researchers made a thorough search of the medical literature and found 10 controlled trials. The 792 participants in these trials received either Ginkgo biloba extract (injection or tablet), placebo, or no additional treatment with their normal supportive care. Treatment began within the first two days to some time later, or was not stated, after onset of stroke. Ginkgo biloba was given as tablets in six trials, at 120 mg to 240 mg per day for 20 to 28 days and as intravenous injections or drips over 14 to 30 days in four other trials.Side effects and general cautions
No major side effects were reported in the three trials that looked for them. Nor were adverse events evident in other identified studies that did not follow the same strict methodological design.The most commonly reported side effects with Ginkgo biloba are mild stomach and intestinal problems such as constipation, indigestion and diarrhoea, and headaches. Serious side effects are rare but include excessive bleeding problems. This means that people who are already taking blood thinners (anti-clotting or anticoagulant and antiplatelet medications) to prevent strokes and heart attacks should consult a doctor before taking Gingko biloba. People who have seizures are also advised to seek medical advice about using this herb.
It is likely that only people with mild strokes were included in these trials and functional ability was not measured. Ability to carry our daily activities of living are important to people as well as neurological impairments.
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