Someone should make a hypothesis of what sensory stimulation on humans would be equivalent(face, hands,genitals?) to a whisker on a rat. This would be so easy to implement and run research on.
Despite progress in reducing ischemic stroke damage, complete protection
remains elusive. Here we demonstrate that, after permanent occlusion of
a major cortical artery (middle cerebral artery; MCA), single whisker
stimulation can induce complete protection of the adult rat cortex, but
only if administered within a critical time window. Animals that receive
early treatment are histologically and behaviorally equivalent to
healthy controls and have normal neuronal function. Protection of the
cortex clearly requires reperfusion to the ischemic area despite
permanent occlusion. Using blood flow imaging and other techniques we
found evidence of reversed blood flow into MCA branches from an
alternate arterial source via collateral vessels (inter-arterial
connections), a potential mechanism for reperfusion. These findings
suggest that the cortex is capable of extensive blood flow
reorganization and more importantly that mild sensory stimulation can
provide complete protection from impending stroke given early
intervention. Such non-invasive, non-pharmacological intervention has
clear translational potential.
Question; Does the infarct location also include motor cortex? white matter? pre-motor cortex? Just trying to see how massive a stroke was generated. They should have cubic volumes listed someplace.
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