So have they thought that maybe pericytes haven't opened up yet?
http://oc1dean.blogspot.com/2011/09/restoring-capillary-blood-flow-after.html
You can easily verify if this hypothesis is correct or not by checking if these problems occur by ischemic vs. hemorrhagic stroke.
http://brainslab.wordpress.com/2012/07/13/38975849/
In everyday life, your muscles, metabolism, and nervous system work
together to ensure that your cerebral blood flow meets the metabolic
needs of your various brain regions. So if you are trying to scrutinize
an impressionist painting, your body will likely relocate more blood flow to your visual cortex.
Following a stroke, this cerebral blood flow regulation is impaired.
But, the degree and spread of the impairment is unknown. To investigate
this, Hu et al. measured systemic blood pressure (BP) and used a transcranial doppler to measure cerebral blood flow velocity (BFV) at the same time.
In their model, better regulation of cerebral blood flow corresponds
to a sharper phase shift between blood pressure (BP) and cerebral blood
flow velocity (BFV). Individuals with the highest score of a 9 on their
autoregulation index (ARI) have more regulation than those with the
lowest score of 0, which corresponds to no phase shift.
When they compared patients who had experienced MCA infarcts (a
common type of stroke) and healthy controls, they found that stroke
patients had significantly less phase coupling between blood pressure
and cerebral blood flow. This effect was pronounced over a wide range of
blood pressure oscillation frequencies.
Given enough time and the right conditions, can the body repair its
ability to regulate cerebral blood flow following a stroke? When the
researchers examined this, they found no statistically significant
difference between the BFV-BP phase difference and time since stroke.
But, that doesn’t mean that there’s a statistically significant lack
of difference. So, further longitudinal studies will be needed to help
clarify whether, in certain people in certain environments, the brain
improves its cerebral regulation following stroke.
Reference
Hu K, Lo M-T, Peng C-K, Liu Y, Novak V (2012) A Nonlinear Dynamic
Approach Reveals a Long-Term Stroke Effect on Cerebral Blood Flow
Regulation at Multiple Time Scales. PLoS Comput Biol 8(7): e1002601.
doi:10.1371/journal.pcbi.1002601
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