Neocortical neurogenesis and neuronal migration

This is way over my head so ask your researcher to dumb it down to a stroke protocol.
http://onlinelibrary.wiley.com/doi/10.1002/wdev.88/full

INTRODUCTION

A prominent trait of the neocortex is its complex yet well-organized cellular architecture, the formation of which relies on the production and positioning of its diverse neuronal populations. There are two major groups of neurons in the neocortex—glutamatergic excitatory neurons and γ-aminobutyric acid (GABA)-ergic inhibitory interneurons, which are responsible for generating excitation and inhibition, respectively. Excitatory neurons constitute the vast majority (∼70–80%) of neocortical circuit neurons and are responsible for generating the output. On the other hand, inhibitory interneurons provide a rich variety of inhibitions that shape the output of functional circuits. Proper neocortex function critically depends on the production and positioning of a correct number of excitatory and inhibitory neurons, which largely occur during the embryonic stages.

With the advent of improved fate-mapping tools, including genetically engineered mice, excitatory and inhibitory neurons in the neocortex were found to arise from different developmental lineages. In rodents, the progenitor cells of these two neuronal populations are fully segregated in space (Figure 1). Excitatory neurons are generated in the proliferative zone of the dorsal telencephalon and then migrate radially to constitute the future neocortex. In contrast, inhibitory interneurons are produced in the proliferative zone of the ventral telencephalon and migrate tangentially to reach the neocortex, where they coassemble with excitatory neurons into functional circuits. This spatial segregation in the excitatory and inhibitory neuron progenitors no doubt further complicates the coordinated production and positioning of these neurons.