Addition of intra-articular hyaluronate injection to physical therapy program produces no extra benefits in patients with adhesive capsulitis of the shoulder: A randomized controlled trial.

A negative result that was published.
http://www.naric.com/research/rehab/record.cfm?search=2&type=all&criteria=J64042&phrase=no&rec=119122
Abstract: Study compared the efficacy of intra-articular hyaluronic acid (HA) injections plus physical therapy (PT) with that of PT alone for the treatment of adhesive capsulitis (AC) of the shoulder. Seventy patients with AC of the shoulder were randomly placed into 1 of two treatment groups. One group received intra-articular glenohumeral joint injections of HA, once per week for 3 consecutive weeks and also participated in a PT program for 3 months. The other group received PT alone. Active and passive range of motion (ROM) of the affected shoulder, pain, disability, and quality of life were assessed before treatment and at 6 and 13 weeks after the beginning of treatment. Both groups experienced improvements in terms of pain, disability, and quality of life after the treatments; furthermore, the active and passive ROM improved linearly with increasing treatment duration. When the groups were compared, no significant group effect was found for any of the outcome measurements. Results suggest that intra-articular HA injections did not produce added benefits for patients with AC of the shoulder who were already receiving PT. Thus, the use of intra-articular HA injections for patients with AC of the shoulder should be carefully assessed to reduce unnecessary medical expenditures.