Saturday, October 20, 2012

Halting Brain Injury

A fascinating idea, lets get clinical trials started.
http://www.medpagetoday.com/Nephrology/KidneyTransplantation/35451?utm_content=&utm_medium=email&utm_campaign=DailyHeadlines&utm_source=WC&xid=NL_DHE_2012-10-20&eun=g424561d0r&userid=424561&email=oc1dean@yahoo.com&mu_id=5523591
The administration of nontoxic carbon particles stabilized the cerebral neurovasculature in a rodent model of traumatic brain injury, restoring critical blood flow and preventing the secondary damage caused by hypotension and free radical release, researchers reported.
Damage to the neurovascular unit is a major predictor of outcome after brain injury, even in mild concussions, when release of reactive oxygen species such as superoxide interferes with resuscitative efforts. Previous efforts to counteract this damaging process using antioxidants have been unsuccessful for reasons including the need for the presence of additional molecules that contribute detoxification.
But carbon particles have no need for these other detoxifying factors, so researchers led by Thomas A. Kent, MD, from Baylor University in Houston tested antioxidant carbon particles in rats following controlled cortical impact and induced hypotension.
"Remarkably," they wrote in ACS Nano, the particle treatment not only restored cerebral blood flow, but also normalized the free radical profile in the animals, suggesting that this approach could provide a novel means of interrupting the cascade of events following brain injury and improving the neurologic outcome for patients.

No comments:

Post a Comment