Warfarin and purple toe syndrome

Beware and see your doctor immediately.
Only 8890 hits from Google scholar for 'purple toe syndrome'
https://www.jstage.jst.go.jp/article/internalmedicine/51/6/51_6_601/_article
Warfarin is widely prescribed for patients with atrial fibrillation. In addition to unexpected bleeding, allergic skin reaction is one of its uncommon adverse effects. We herein report an 89-year-old man who, after taking warfarin for 4 years, suffered extensive skin eruptions. The skin biopsy disclosed leukocytoclastic vasculitis. The causal relationship between skin lesions and warfarin was confirmed after re-challenge of warfarin. A literature review revealed only 13 such cases reported from 1980 to 2011. Clinicians should be aware of this potential adverse effect of warfarin.