Depressed mice getting neurogenesis, Get some human clinical trials going.
Abstract
The present study examined the
effects of enzymatically hydrolyzed collagen peptides on the level of
hippocampal neurogenesis and emotional behavior in adult mice. For this
purpose, two kinds of enzymatically hydrolyzed collagen peptides, the
lower or higher molecular weight peptides (LP: below 2,000, HP: about
30,000) were administered orally to C57BL/6 mice for 4 weeks. As a
result, the density of proliferating cells in subgranular zone of
hippocampus showed a 1.2-fold increase in LP mice as compared with HP
mice. Additionally, LP mice spent less time in closed arms than HP mice
in elevated plus maze test to examine anxiety-related behavior. These
results suggest that oral administration of the lower molecular weight
peptides derived from collagen enhanced the hippocampal neurogenesis and
exerted emotional behavior in adult mice.
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