Epigenetics and stroke risk - beyond the static DNA code

I'm sure your doctor can explain exactly how your DNA is influenced by epigenetics and that correlation with stroke risk.

Reference Type: Journal Article
Record Number: 1
Author: Matouk CC, Turgeon PJ, Marsden PA
Year: 2012
Title: Epigenetics and stroke risk – beyond the static DNA code
Journal: Advances in Genomics and Genetics
Volume: 2
Issue: 1
Pages: 67-84
Date: 16 October 2012
Short Title: Epigenetics and stroke risk  beyond the static DNA code
DOI: http://dx.doi.org/10.2147/AGGS18697
Abstract: Abstract:
Advances in high-throughput genome sequencing and genome-wide association studies indicate that only a fraction of estimated variability in stroke risk can be explained by genetic variation in protein-coding genes alone. Epigenetics is defined as chromatin-based mechanisms important in the regulation of gene expression that do not involve changes in the DNA sequence per se. Epigenetics represents an alternative explanation for how traditional risk factors confer increased stroke risk, provide a newer paradigm to explain heritability not explained by genetic variation, and provide insight into the link between how the environment of a cell can interact with the static DNA code. The nuclear-based mechanisms that contribute to epigenetic gene regulation can be separated into three distinct but highly interrelated processes: DNA methylation and hydroxymethylation; histone density and posttranslational modifications; and RNA-based mechanisms. Together, they offer a newer perspective on transcriptional control paradigms in blood vessels and provide a molecular basis for understanding how the environment impacts the genome to modify stroke susceptibility. This alternative view for transcriptional regulation allows a reassessment of the cis/trans model and even helps explain some of the limitations of current approaches to genetic-based screens. For instance, how does the environment exert chronic effects on gene expression in blood vessels after weeks or years? When a vascular cell divides, how is this information transmitted to daughter cells? This review provides an introduction to epigenetic concepts and a conceptual framework for understanding the
URL: http://www.dovepress.com/epigenetics-and-stroke-risk-ndash-beyond-the-static-dna-code-peer-reviewed-article-AGG