Friday, December 14, 2012

Nerve Growth Factor-Potentiating Benzofuran Derivatives from the Medicinal Fungus Phellinus ribis

You'll need to pass this off to your doctors so they can ask their researchers to create a stroke protocol from this. Neurite outgrowth is something we need.
http://pubs.acs.org/doi/abs/10.1021/np300566y

Abstract

Abstract Image
Four new benzofuran derivatives, ribisin A (1), ribisin B (2), ribisin C (3), and ribisin D (4), were isolated from the MeOH extract of the fruiting bodies of Phellinus ribis. Their structures including their absolute configurations were determined by NMR and CD exciton chirality methods. Compounds 14 were found to promote neurite outgrowth in NGF-mediated PC12 cells at concentrations ranging from 1 to 30 μM. The structure–activity relationships of these compounds are also discussed.

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