Why drug discovery is so hard

A couple of interesting writeups on this. I wish I could be confident that drugs to stop the neuronal cascade of death will be found but as Dr. Michael Tymianski, of the Toronto Western Hospital Research Institute in Canada mentions 1000 drugs that showed promise in animal models failed in human trials. I have yet to find out why they failed and what has been learned from those failures.

I could care less about it being hard. A Great stroke association would gladly tackle this issue. But alas we  have non-functional ones like the ASA, NSA and WSO. Please respond with your excuses, I will print them.

This is way too important to leave it to drug companies to figure out. We as survivors need to push researchers to explain what they have already done and ruled out and what their plans  look like to successfully come up with a neuroprotective drug.

1.A Broadside Against The Way We Do Things Now 
---------------------------------------------------------------------------------------------

2. Traditional drug-discovery model ripe for reform

--------------------------------------------------------------------------------------------

 

3.What are the main discovery issues facing drug discovery companies right now? 

----------------------------------------------------------------------------------------------------

4.  Drug discovery in jeopardy

-----------------------------------------------------------------------------------------------------

5.  Drug Discovery  The Pending Crisis

------------------------------------------------------------------------------------------------------

6.  Future Directions in Drug Design & Discovery

-----------------------------------------------------------------------------------------

7. Major Issues and Trends in Drug Discovery and Development: India’s Emerging Role

--------------------------------------------------------------------------------------------

8.  The end of drug discovery?

-------------------------------------------------------------------------------------------------------

9.   CNS Drug Discovery & Development 2012: Problems, Promises and Solutions

-----------------------------------------------------------------------------------------------------------