Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,42 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke. DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Sunday, January 6, 2013
Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis
Liver X receptors (Lxrα and Lxrβ) are ligand-dependent nuclear receptors critical for ventral midbrain neurogenesis in vivo. However, no endogenous midbrain Lxr ligand has so far been identified. Here we used LC/MS and functional assays to identify cholic acid as a new Lxr ligand. Moreover, 24(S),25-epoxycholesterol (24,25-EC)
was found to be the most potent and abundant Lxr ligand in the
developing mouse midbrain. Both Lxr ligands promoted neural development
in an Lxr-dependent manner in zebrafish in vivo. Notably, each ligand selectively regulated the development of distinct midbrain neuronal populations. Whereas cholic acid increased survival and neurogenesis of Brn3a-positive red nucleus neurons, 24,25-EC
promoted dopaminergic neurogenesis. These results identify an entirely
new class of highly selective and cell type–specific regulators of
neurogenesis and neuronal survival. Moreover, 24,25-EC
promoted dopaminergic differentiation of embryonic stem cells,
suggesting that Lxr ligands may thus contribute to the development of
cell replacement and regenerative therapies for Parkinson's disease.
No comments:
Post a Comment