Monday, February 18, 2013

Role of NMDA receptors in adult neurogenesis: an ontogenetic (re)view on activity-dependent development

Your neurologist will be able to summarize all these v207 posts on neurogenesis and be able to tell you exactly how to use them to recover. I know, fantasyland, but if you don't demand an answer now we won't have that answer in  30 years when your children will need it.
http://www.ncbi.nlm.nih.gov/pubmed/23397131

Abstract

It is now widely accepted that neurogenesis continues throughout life. Accumulating evidence suggests that neurotransmitters are essential signaling molecules that control the different steps of neurogenesis. Nevertheless, we are only beginning to understand the precise role of neurotransmitter receptors and in particular excitatory glutamatergic transmission in the differentiation of adult-born neurons. Recent technical advances allow single-cell gene deletion to study cell-autonomous effects during the maturation of adult-born neurons. Single-cell gene deletion overcomes some of the difficulties in interpreting global gene deletion effects on entire brain areas or systemic pharmacological approaches that might result in compensatory circuit effects. The aim of this review is to summarize recent advances in the understanding of the role of NMDA receptors (NMDARs) during the differentiation of adult-born neurons and put them in perspective with previous findings on cortical development.

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