AN INFLAMMATORY FINDING Mice Aren’t Men

This is probably why the 1000 studies that worked in rodents but failed in humans, as Dr. Tymianski noted years ago. Inflammation is extremely important to figure out in the stroke aftermath.

AN INFLAMMATORY FINDING Mice Aren’t Men

A recent paper coauthored by associate professor of pediatrics H. Shaw Warren does just that. In a study that involved collaboration among more than a dozen institutions, Warren, an expert in sepsis (see below), asked whether the bodies of mice react to burns, blunt trauma, and infection the same way that human bodies do. Examining the genetic signatures of response to such assaults, the scientists found very little similarity between the two species.
The finding is stunning because mice have long been considered a model organism for researching drugs for use in people. The study authors estimate that 150 potential treatments for severe inflammation have been tested in people after being found to work in mice—and in the human trials, not a single one worked.

Full article at the link.