Friday, May 17, 2013

Systematic review of the effectiveness of pharmacological interventions in the treatment of spasticity of the hemiparetic lower extremity more than six months post stroke

Demand your doctor get this and let you read it. I bet nothing has worked for your spasticity yet so you better find out if anything works. The abstract looks pretty hopeless.
http://search.naric.com/research/rehab/redesign_record.cfm?search=2&type=all&criteria=J65519&phrase=no&rec=120915
NARIC Accession Number: J65519.  What's this?
ISSN: 1074-9357.
Author(s): McIntyre, Amanda; Lee, Taeweon; Janzen, Shannon; Mays, Rachel; Mehta, Swati; Teasell, Robert.
Publication Year: 2012.
Number of Pages: 12.
Abstract: Study examined the effectiveness of pharmacological interventions in reducing spasticity of the lower limb in chronic stroke survivors. PubMed, CINAHL, and EMBASE were searched for randomized controlled trials (RCTs) in which patients who were at least 6 months post stroke received a pharmacological intervention aimed at treating lower-limb spasticity. Methodological quality of each study was assessed using the Physiotherapy Evidence Database (PEDro) tool. Nine RCTs (PEDro scores, 4 to 9) met the inclusion criteria and included a pooled sample size of 605 individuals with a mean age of 54.8 years. Four RCTs provided evidence that botulinum toxin type A was effective in reducing spasticity compared to participants receiving placebo or a phenol neurolytic. One study provided evidence that both alcohol and phenol neurolytics were effective in reducing spasticity. Finally, 4 studies provided evidence that oral and intrathecal medications were effective in reducing lower-limb spasticity compared to placebo. Findings indicated that pharmacological treatment initiated 6 months post stroke reduced lower-limb spasticity. Relevant areas of exploration for future research could include the period of effectiveness, long-term complications, and a cost-benefit analysis of such treatments.

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