CEACAM1: An Adhesion Molecule That Limits Blood–Brain Barrier Damage by Neutrophils After Stroke

More unavailability of research. It sounds like something our doctors should be doing immediately post-stroke.  Have your doctor get it and tell you what changes will be made for your next stroke.
http://circres.ahajournals.org/content/113/8/952.full.pdf+html

This item requires a subscription to Circulation Research.

PDF

CEACAM1: An Adhesion Molecule That Limits Blood–Brain Barrier Damage by Neutrophils After Stroke Circulation Research. 2013;113:952-953,

To view this item, select one of the options below:

Sign In

User Name Password Remember my user name & password.

Forgot your user name or password?

• Can't get past this page?
• Help with Cookies.
• Need to Activate?

Purchase Short-Term Access

• Pay per Article - You may access this article (from the computer you are currently using) for 1 day for US$20.00.
• Pay for Admission - You may access all content in Circulation Research (from the computer you are currently using) for 1 day for US$40.00.
• Regain Access - You can regain access to a recent Pay per Article or Pay for Admission purchase if your access period has not yet expired.

Sign Up

• Become a Member - Join the American Heart Association.
• Subscribe to the Journal - Subscribe to the print and/or online journal. 

---------------------------------------------------------------------------------------------------------
Ok, I found the abstract;

Carcinoembryonic Antigen–Related Cell Adhesion Molecule 1 Inhibits MMP-9–Mediated Blood–Brain–Barrier Breakdown in a Mouse Model for Ischemic Stroke

Abstract 

Rationale: Blood–brain–barrier (BBB) breakdown and cerebral edema result from postischemic inflammation and contribute to mortality and morbidity after ischemic stroke. A functional role for the carcinoembryonic antigen–related cell adhesion molecule 1 (CEACAM1) in the regulation of reperfusion injury has not yet been demonstrated.

Objective: We sought to identify and characterize the relevance of CEACAM1-expressing inflammatory cells in BBB breakdown and outcome after ischemic stroke in Ceacam1^−/− and wild-type mice.

Methods and Results: Focal ischemia was induced by temporary occlusion of the middle cerebral artery with a microfilament. metalloproteinase-9⁺ neutrophils in the ischemic hemispheres.

Conclusions: CEACAM1 controls matrix metalloproteinase-9 secretion by neutrophils in postischemic inflammation at the BBB after stroke. We propose CEACAM1 as an important inhibitory regulator of neutrophil-mediated tissue damage and BBB breakdown in focal cerebral ischemia.

Key Words: