http://informahealthcare.com/doi/abs/10.3109/01913123.2013.846449
December 2013, Vol. 37, No. 6
,
Pages 425-432
(doi:10.3109/01913123.2013.846449)
Viorel Pais, PhD1, Leon Danaila, MD, PhD1, and Emil Pais, DDS, MS2
1Department of Neurosurgery, National Institute of Neurology and Neurovascular Diseases,
Bucharest
, Romania and
2Spectral Molecular Imaging,
Los Angeles, CA
, USAAbstract
This
study is based on data analysis by light and transmission electron
microscopy of the surgical cases in cerebral tumors, cerebrovascular
malformations, thromboses in the carotid system, and other injuries such
as perivascular hemorrhage. We examined cortical arteries and veins,
perivascular areas with old hematic masses, vasculogenic foci, and
broken large vessels. We identified, characterized, and compared both
undifferentiated cells and well-differentiated cordocytes within
periadventitial areas where these cells cooperate very well with
precursor/stem cells to perform vital functions for cerebral vasculature
with immediate effect on brain parenchyma. This useful cellular
cooperation was observed by serial sections pointing out the main role
of cordocytes during the entire process of collateral vessel formation
after thrombosis and, respectively, in vascular wall repair after
ruptures. This is the first cytohistopathological study which
illustrates and explains some facets of cordocytes-stem cells
cooperation around the vessels of human brain with emphasis on the
fundamental role of cordocytes in response to vascular injuries. Our
pioneering study will be completed for both basic science and modern
medical care by further studies.
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