Thursday, November 14, 2013

Oligodendrogenesis after cerebral ischemia

What is your doctor doing to make sure this happens? And if your doctor doesn't know what oligodendrocytes do then you have an idiot for a doctor?

Oligodendrogenesis after cerebral ischemia



Ruilan Zhang1, Michael Chopp1,2 and Zheng Gang Zhang1*

  • 1Department of Neurology, Henry Ford Hospital, Detroit, MI, USA
  • 2Department of Physics, Oakland University, Rochester, MI, USA
Neural stem cells in the subventricular zone (SVZ) of the lateral ventricle of adult rodent brain generate oligodendrocyte progenitor cells (OPCs) that disperse throughout the corpus callosum and striatum where some of OPCs differentiate into mature oligodendrocytes. Studies in animal models of stroke demonstrate that cerebral ischemia induces oligodendrogenesis during brain repair processes. This article will review evidence of stroke-induced proliferation and differentiation of OPCs that are either resident in white matter or are derived from SVZ neural progenitor cells and of therapies that amplify endogenous oligodendrogenesis in ischemic brain.

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