Monday, November 25, 2013

Omega-3 fatty acids and traumatic neurological injury: from neuroprotection to neuroplasticity?

I know this says this needs review before clinical translation but I'm going to insist on this because of these already; Ask your doctor, whats the downside?
Fish oil.
     either by injection
http://oc1dean.blogspot.com/2013/03/fish-oil-may-help-stroke-patients.html
     or a feeding tube
http://oc1dean.blogspot.com/2012/10/fish-oil-for-brain-injuries-tbi.html

 http://www.sciencedirect.com/science/article/pii/S0166223613001987
  • Centre for Neuroscience and Trauma, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK

Highlights

Evidence for positive effects of omega-3 polyunsaturated fatty acids (PUFA) in CNS.
Omega-3 PUFAs potential treatment for spinal cord or traumatic brain injury.
Omega-3 PUFA delivery after or dietary exposure prior to injury improves outcomes.
Neuroprotective effects of omega-3 PUFAs likely mediated via multiple pathways.
Understanding role of omega-3 PUFAs in neuroplasticity critical next step.

Omega-3 polyunsaturated fatty acids (PUFAs) are compounds that have a structural role in the nervous system and are essential for neurodevelopment. Results obtained with docosahexaenoic acid and eicosapentaenoic acid show therapeutic potential in neurotrauma. Traumatic brain injury (TBI) and spinal cord injury (SCI) can lead to major disability and have a significant socioeconomic cost. Thus, there is an unmet need for acute neuroprotection and for treatments that promote neuroregeneration. Acute administration of omega-3 PUFAs after injury and dietary exposure before or after injury improve neurological outcomes in experimental SCI and TBI. The mechanisms involved include decreased neuroinflammation and oxidative stress, neurotrophic support, and activation of cell survival pathways. This review raises questions that must be addressed before successful clinical translation.

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