Is stroke rehabilitation a metabolic problem?

Well I don't know so ask your doctor that question. And an email is provided for your doctors ease in contacting the researcher.

Is stroke rehabilitation a metabolic problem?

2014, Vol. 28, No. 2 , Pages 161-173 (doi:10.3109/02699052.2013.860470)

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Roberto Aquilani¹, Mirella Boselli², Baiardi Paola³, Evasio Pasini⁴, Paolo Iadarola⁵, Manuela Verri⁶, Simona Viglio⁷, Annamaria Condino⁸, & Federica Boschi⁸

¹Servizio di Fisiopatologia Metabolico-Nutrizionale e Nutrizione Clinica,

²Unità di Riabilitazione Neuromotoria, Unità Gravi Cerebrolesioni Acquisite, Fondazione S. Maugeri, IRCCS, Istituto Scientifico di Montescano,

Montescano, Pavia

, Italy,

³Consorzio Valutazioni Biologiche e Farmacologiche, Fondazione S. Maugeri e Università degli Studi di Pavia,

Pavia

, Italy,

⁴Fondazione S. Maugeri, IRCCS, Istituto Scientifico di Lumezzane,

Lumezzane, Brescia

, Italy,

⁵Dipartimento di Biologia e Biotecnologie, Università degli Studi di Pavia,

Pavia

, Italy,

⁶Dipartimento di Medicina Legale, Scienze Forensi e Farmaco-Tossicologiche ‘A. Fornari’, Sezione di Scienze Farmacologiche e Tossicologiche, Università degli Studi di Pavia,

Pavia

, Italy,

⁷Dipartimento di Medicina Molecolare, and

⁸Dipartimento di Scienze del Farmaco, Università degli Studi di Pavia,

Viale Taramelli, Pavia

, Italy

Correspondence:

Dr Federica Boschi

, Dipartimento di Scienze del Farmaco, Università degli Studi di Pavia,

Viale Taramelli, 12, 27100 Pavia

, Italy. Tel: 39-0382-987398. Fax: 39-0382-987405. Email: federica.boschi@unipv.it

Abstract

Background: This study looks at the impact of inflammation during the rehabilitation stage of strokes and its effect on neuro-functional recovery.
Methods: This study investigated 94 patients suffering from strokes and admitted to rehabilitation. Anthropometric characteristics, serum proteins and inflammatory markers, plasma amino acids and neurofunction were all assessed.
Results: 55.3% patients had an inflammatory status (Interleukin-6 = 19.24 ± 23.01 pg ml⁻¹ vs. 4.1 ± 1.6 pg ml⁻¹ for non-inflamed subjects (p < 0.001). Inflammation was positively linked to positive proteins (alpha-1 globulin, p < 0.02) and negatively linked to negative proteins (albumin, p < 0.02; prealbumin, p < 0.01; transferrin, p  < 0.05) of the acute-phase response. Inflammation was associated with low plasma concentrations of total amino acids. For the multiple logistic regression analysis, albumin (p < 0.001) and body weight maintenance (p  < 0.001) were independent predictors of patient functional independence. Inflammation in dysphagic stroke (31.9%) patients was associated with more accentuated disability compared to non-inflamed dysphagics. The serum positive reactant alpha 1 globulin was the most powerful predictor of dysphagia severity (p < 0.001). At discharge, dysphagia improvement was associated with improved acute-phase negative proteins.

Conclusions: An inflammatory status may persist for most patients with strokes during the rehabiliation stage of the disease, its prevalence being higher in dysphagic compared to non-dysphagic subjects. The improvement in circulating albumin(how is that done?) and body weight maintenance are predictors of neuro-function, even in dysphagic subjects.

Read More: http://informahealthcare.com/doi/abs/10.3109/02699052.2013.860470