Thursday, February 13, 2014

Gout Culprit Promising as Acute Stroke Tx - Uric acid

Will this be enough proof to have this as a standard stroke protocol? Who is going to roll this out?
http://www.medpagetoday.com/MeetingCoverage/ISCNeuroEdition/44276?
Uric acid given along with thrombolytics in the first hours after an ischemic stroke showed a signal for improved recovery, a Spanish proof-of-concept trial showed.
The rate of near full recovery at 90 days was 39.3% with the powerful antioxidant compared with 33% on placebo instead, Angel Chamorro, MD, PhD, of the Hospital Clinic in Barcelona, Spain, and colleagues reported here at the International Stroke Conference.
That 23% relative reduction in risk of a modified Rankin score greater than 1, reflecting poor functional outcome, at 90 days didn't reach statistical significance in the 421-patient URICO-ICTUS Study (P=0.099).
But the magnitude of reduction in median modified Rankin score -- 3 points on uric acid versus 2 on placebo (P=0.045) -- was on par with recombinant tissue plasminogen activator (rtPA) in the pivotal trial, Chamorro argued.

More at link.

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