Monday, March 24, 2014

Traffic lights for axon growth: proteoglycans and their neuronal receptors

You'll have to ask your neurologist which is more important; axon pathfinding or neurite outgrowth? And what the difference in stroke protocols is for each one. Your doctor had better know all this stuff.
You do expect 100% recovery using their knowledge, Don't you?
http://scholar.google.com/scholar_url?hl=en&q=http://www.sjzsyj.org/CN/article/downloadArticleFile.do%3FattachType%3DPDF%26id%3D877&sa=X&scisig=AAGBfm30FvKanYgSdCrIp26fg0A2dvV2qQ&oi=scholaralrt


Yingjie Shen

Department of Neuroscience and Center for Brain and Spinal Cord Repair, Wexner Medical Center, The Ohio State University, 460 w 12th Ave,

Columbus, OH 43210, USA

Abstract

Axon growth is a central event in the development and post-injury plasticity of the nervous
system. Growing axons encounter a wide variety of environmental instructions. Much like traffic
lights in controlling the migrating axons, chondroitin sulfate proteoglycans (CSPGs) and heparan
sulfate proteoglycans (HSPGs) often lead to “stop” and “go” growth responses in the axons,
respectively. Recently, the LAR family and NgR family molecules were identified as neuronal
receptors for CSPGs and HSPGs. These discoveries provided molecular tools for further study of
mechanisms underlying axon growth regulation. More importantly, the identification of these
proteoglycan receptors offered potential therapeutic targets for promoting post-injury axon regeneration.

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