Wednesday, April 9, 2014

Cough reflex induced by capsaicin inhalation in patients with dysphagia

I'm quite positive you will never get this test. Inhaling the hotness of peppers seems unlikely to be aproved by your hospital.
http://informahealthcare.com/doi/abs/10.3109/00016489.2010.516013
January 2011, Vol. 131, No. 1 , Pages 96-100 (doi:10.3109/00016489.2010.516013)
1Division of Otorhinolaryngology Head & Neck Surgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Science, University of Fukui, Fukui
2Department of Otorhinolaryngology, Tannan Regional Medical Center, Fukui
3Department of Otorhinolaryngology, Maizuru Kyosai Hospital, Kyoto, Japan
Correspondence: Shigeharu Fujieda MD, Chairman of Otorhinolaryngology Head & Neck Surgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Science, University of Fukui, 23 Shimoaizuki, Matsuoka, Yoshida, Eiheiji, Fukui, 910-1193, Japan. +81 776 61 8407. +81 776 61 8118.

Abstract

Conclusions: We conclude that the capsaicin inhalation test is useful to directly assess cough reflex and sensation around the larynx, while it indirectly reflects central nervous system function. Objectives: To understand the state of the cough reflex before patients with dysphagia start eating. Methods: We studied the cough reflex by the capsaicin inhalation test in 21 patients with dysphagia and 12 healthy persons without dysphagia. Results: The control group showed a cough reflex at a capsaicin concentration of 2.61 μM (0.98–7.80), while patients with mild dysphagia did so at 7.28 μM (1.95–15.6), those with moderate dysphagia at 22.07 μM (15.6–62.5), and those with severe dysphagia at 71.75 μM (31.2–250). Control vs mild p < 0.01, control vs moderate p < 0.01, control vs severe p < 0.01, mild vs moderate p < 0.01, mild vs severe p < 0.01, moderate vs severe p < 0.05. There was a significant correlation between the grade of dysphagia and the threshold capsaicin concentration that provoked a cough reflex (ρ = –0.796, p < 0.001).



Read More: http://informahealthcare.com/doi/abs/10.3109/00016489.2010.516013

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