Melatonin plus treadmill exercise synergistically promotes neurogenesis and reduce apoptosis in focal cerebral ischemic rats (877.17)

This would be so simple to construct a human clinical trial on this. Why hasn't your doctor started it up yet? Melatonin is easily available. However, don't do this, you know how dangerous doing anything without your doctors ok is. Side effects here:
And treadmills are dammed dangerous.
http://www.fasebj.org/content/28/1_Supplement/877.17.short

1. Minkyung Lee2,
2. Seunghoon Lee2 and
3. Yonggeun Hong2,1

+ Author Affiliations

1. ¹Cardiovascular & Metabolic Disease Center, College of Biomedical Science & Engineering, Inje University Gimhae Korea, Republic of
2. ²Department of Rehabilitation Science in Interdisciplinary PhD Program Graduate School of Inje University Gimhae Korea, Republic of

Abstract

Ischemic stroke results from sudden decrease or loss of blood flow to the brain, resulting in damage to neurological function and neuronal networks, cognition. The purpose of this study, we determined whether melatonin and/or treadmill exercise could induce neurogenesis, thereby promoting functional recovery in ischemic brain. Following the MCAo, Sprague-Dawley (SD) rats were randomly divided into control (Con), MCAo, MCAo+Exercise (MCAo+Ex), MCAo+Melatonin (MCAo+MT), Melatonin combined Exercise in MCAo (MCAo+MT+Ex). The 8 week old SD rats were treated twice daily with melatonin (10 mg/kg) at 17:00 and 19:00, and trained twice daily with treadmill exercise (20 m/min, 6 days/week) at 17:00 and 22:00. At the Golgi-cox staining, dendrite density in the MCAo+MT+Ex group was higher than in MCAo group. We confirmed that MCAo+MT+ME group was significantly recovered the neurological symptom in behavioral assessment (p<.01). Moreover, MCAo+MT and MCAo+MT+Ex were significantly increased both DCx and GFAP mRNA expression. In conclusion, we suggest that melatonin with and without treadmill exercise intervention enhanced neurogenesis and neuronal cell reconstruction in damaged brain lesions, thereby induced improvement of neurological dysfunction in animal model. Key words: Melatonin, Treadmill exercise, Neurogenesis, Apoptosis, Focal cerebral ischemia