This was written up a year ago here:
http://oc1dean.blogspot.com/2013/05/factor-that-reverses-aging-of-heart.html
Why haven't we seen any human trials? I'm sure we could get grandchildren to donate blood. And if it works this would be so damned simple to implement. All the more reason to cultivate young friends. Well this is in mice but would you attempt this anyway?
http://www.nature.com/nm/journal/vaop/ncurrent/abs/nm.3569.html
As human lifespan increases, a greater fraction of the population is
suffering from age-related cognitive impairments, making it important to
elucidate a means to combat the effects of aging1, 2.
Here we report that exposure of an aged animal to young blood can
counteract and reverse pre-existing effects of brain aging at the
molecular, structural, functional and cognitive level. Genome-wide
microarray analysis of heterochronic parabionts—in which circulatory
systems of young and aged animals are connected—identified synaptic
plasticity–related transcriptional changes in the hippocampus of aged
mice. Dendritic spine density of mature neurons increased and synaptic
plasticity improved in the hippocampus of aged heterochronic parabionts.
At the cognitive level, systemic administration of young blood plasma
into aged mice improved age-related cognitive impairments in both
contextual fear conditioning and spatial learning and memory. Structural
and cognitive enhancements elicited by exposure to young blood are
mediated, in part, by activation of the cyclic AMP response element
binding protein (Creb) in the aged hippocampus. Our data indicate that
exposure of aged mice to young blood late in life is capable of
rejuvenating synaptic plasticity and improving cognitive function.
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