http://link.springer.com/article/10.1007/s12975-014-0357-7
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Abstract
Aerobic exercise may be
a catalyst to promote neuroplasticity and recovery following stroke;
however, the optimal methods to measure neuroplasticity and the effects
of training parameters have not been fully elucidated. We conducted a
systematic review and synthesis of clinical trials and studies in animal
models to determine (1) the extent to which aerobic exercise influences
poststroke markers of neuroplasticity, (2) the optimal parameters of
exercise required to induce beneficial effects, and (3) consistent
outcomes in animal models that could help inform the design of future
trials. Synthesized findings show that forced exercise at moderate to
high intensity increases brain-derived neurotrophic factor (BDNF),
insulin-like growth factor-I (IGF-I), nerve growth factor (NGF), and
synaptogenesis in multiple brain regions. Dendritic branching was most
responsive to moderate rather than intense training. Disparity between
clinical stroke and stroke models (timing of initiation of exercise,
age, gender) and clinically viable methods to measure neuroplasticity
are some of the areas that should be addressed in future research.
Within this Article
- Introduction
- Methods
- Results
- Discussion
- Summary of Recommendations
- Conclusion
- References
- References
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