Clinical Significance in Dementia Research A Review of the Literature

And if there were any f*cking brains at all in the stroke world an article like this on stroke would be written each year. Or maybe we should have this as an assignment for grad students at all the top neurology programs because it won't get done otherwise.
http://aja.sagepub.com/content/29/6/492?etoc

1. Syed H. Shabbir, BSc1
2. Amy E. Sanders, MD, MS1⇑

1. ¹Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA

1. Amy E. Sanders, MD, MS, Albert Einstein College of Medicine, Louis and Dora Rousso Building, 1165 Morris Park Avenue, Room 311, Bronx, NY 10461, USA. Email: amy.sanders@einstein.yu.edu

Abstract

Clinical research traditionally relies on measures of statistical significance to assess the strength of evidence while less attention is paid to the practical import of the results. The objective of this study was to provide a critical overview of the current approaches to measuring clinical significance in dementia research and to provide suggestions for future research. A systematic search was conducted of Medline and Embase for original, English-language, peer-reviewed articles published before July 2012. A total of 18 articles met the inclusion criteria, of which 13 used multiple approaches to measure clinical significance. In all, 5 articles used expert opinion as anchors; 4 also used distribution-based approaches. In all, 8 articles used Goal Attainment Scaling; 7 of these also relied on clinician-based impressions of change. Another 3 articles used only clinical global impressions of change, 1 article used changes in symptomatology, and another used the value from literature.