Impairment of paravascular clearance pathways in the aging brain

Another possible reason for your cognitive decline. Has your doctor ruled out the more obscure ones or just used Occams razor to point to your stroke as the cause.?
http://onlinelibrary.wiley.com/doi/10.1002/ana.24271/abstract

1. Benjamin T. Kress^1,†,
2. Jeffrey J. Iliff^1,2,3,†,*,
3. Maosheng Xia^1,4,
4. Minghuan Wang¹,
5. Helen Wei¹,
6. Douglas Zeppenfeld²,
7. Lulu Xie¹,
8. Hongyi Kang¹,
9. Qiwu Xu¹,
10. Jason Liew¹,
11. Benjamin A. Plog¹,
12. Fengfei Ding^1,2,
13. Rashid Deane¹ and
14. Maiken Nedergaard^1,*

DOI: 10.1002/ana.24271

Abstract

Objective: In the brain, protein waste removal is partly performed by paravascular pathways that facilitate convective exchange of water and soluble contents between cerebrospinal and interstitial fluids. Several lines of evidence suggest that bulk flow drainage via the glymphatic system is driven by cerebrovascular pulsation, and is dependent on astroglial water channels that line paravascular cerebrospinal fluid (CSF) pathways. The Objective of this study was to evaluate whether the efficiency of CSF-ISF exchange and interstitial solute clearance is impaired in the aging brain.

Methods: CSF-ISF exchange was evaluated by in vivo and ex vivo fluorescence microscopy while interstitial solute clearance was evaluated by radio-tracer clearance assays in young (2-3 month), middle age (10-12 month) and old (18-20 month) wild type mice. The relationship between age-related changes in the expression of the astrocytic water channel aquaporin-4 (AQP4) and changes in glymphatic pathway function were evaluated by immunofluorescence.

Results: Advancing age was associated with a dramatic decline in the efficiency of exchange between the subarachnoid CSF and the brain parenchyma. Relative to the young, clearance of intraparechamally injected amyloid β was impaired by 40% in the old mice. A 27% reduction in the vessel wall pulsatility of intracortical arterioles and widespread loss of perivascular AQP4 polarization along the penetrating arteries accompanied the decline in CSF-ISF exchange.

Interpretation: We propose that impaired glymphatic clearance contributes to cognitive decline among the elderly and may represent a novel therapeutic target for the treatment of neurodegenerative diseases associated with accumulation of mis-folded protein aggregates.
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