Wednesday, October 15, 2014

Breakthrough Replicates Human Brain Cells for Use in Alzheimer’s Research

Our stroke associations should be able to copy this work and support scientists that can create 'Stroke in a dish'. With that they could see what works to save neurons from the neuronal cascade of death. And listen to signals between neurons so we can find out exactly how damaged neurons can be repaired. Yet I doubt any one will look at this and see how it can be reused for stroke.  We must have complete idiots in charge of stroke strategy. Or worse yet, no strategy at all.
http://www.nytimes.com/2014/10/13/science/researchers-replicate-alzheimers-brain-cells-in-a-petri-dish.html?
For the first time, and to the astonishment of many of their colleagues, researchers created what they call Alzheimer’s in a Dish — a petri dish with human brain cells that develop the telltale structures of Alzheimer’s disease. In doing so, they resolved a longstanding problem of how to study Alzheimer’s and search for drugs to treat it; the best they had until now were mice that developed an imperfect form of the disease.
The key to their success, said the lead researcher, Rudolph E. Tanzi of Massachusetts General Hospital in Boston, was a suggestion by his colleague Doo Yeon Kim to grow human brain cells in a gel, where they formed networks as in an actual brain. They gave the neurons genes for Alzheimer’s disease. Within weeks they saw the hard Brillo-like clumps known as plaques and then the twisted spaghetti-like coils known as tangles — the defining features of Alzheimer’s disease.
The work, which also offers strong support for an old idea about how the disease progresses, was published in Nature on Sunday. Leading researchers said it should have a big effect.

More at link.

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