Wednesday, November 5, 2014

Inhibitory Neurons: Keeping the Brain’s Traffic in Check

Your doctor and our stroke associations should be researching into how to inhibit these Inhibitory Neurons post-stroke in order not to have to need quite so strong a signal to send messages. Ask when they are going to have an answer, this century or next century?
http://knowingneurons.com/2014/11/05/inhibitory-neurons-keeping-the-brains-traffic-in-check/
Imagine that you’re driving down a road undeterred, no red lights or stop signs to slow you down. While that may seem like a very exciting idea, it is obviously very dangerous, since our roads are not all parallel, but interconnected in a number of different ways. For traffic to go smoothly in all directions, we have stop signs, red lights, speed bumps and police cars to make sure no accidents occur. In much the same way, our brain has a mechanism to keep the excitation in check. Information in the brain flows via excitatory neurons that have properties depending on their anatomical location. For example, a neuron in the visual cortex will respond to visual stimuli, and a neuron in the auditory cortex will respond to auditory stimuli. Since excitation cannot go on forever, we have to make sure it slows down or stops whenever required. This is known as inhibition. Inhibition is as important as excitation, if not more so. The neurons that perform this function are known as inhibitory neurons, and they have the special property of making sure our brain functions smoothly and is accident-free.
When activated, GABAergic neurons release the neurotransmitter GABA, which is known to hyperpolarize the postsynaptic neurons, i.e. it makes the membrane potential more negative, making it harder for the neuron to reach the threshold to fire an action potential, thereby causing ‘inhibition’. Most often, inhibitory neurons are also called GABAergic neurons for that reason. Although they constitute only 20-25% of all neurons in the cortex, they are strikingly diverse, with different morphologies, sizes, intrinsic properties, connectivity patterns, and protein expression. Based on their molecular properties, a significant effort has been made in recent years to classify them into subgroups [1]. Let’s explore a few of the major inhibitory neuron subtypes:

Pictures and more at link that I'm positive your doctor will not be able to describe. 


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