If the conclusions from this are truly proven out, then marijuana may be an essential protocol for stroke rehab and heart rehab. Do not self-prescribe.
My 13 reasons to use it post-stroke.
Cannabis smoking and serum C-reactive protein: A quantile regressions approach based on NHANES 2005–2010
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Highlights
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- We present estimates on cannabis smoking-attributable immunomodulation as manifest in serum CRP levels.
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- Evidence suggesting cannabis-antiinflammatory effects emerges at CRP levels below the median.
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- Stratification by BMI disclosed no appreciable variation of the cannabis–CRP relationship.
Abstract
Background
Pre-clinical
studies link cannabinoid-1 receptor activation to inflammation and
atherosclerotic effects; anti-inflammation and immunosuppression seem to
be mediated by cannabinoid-2 receptor activation. In this
epidemiological study, we aim to present estimates on suspected
cannabis-attributable immunomodulation as manifest in serum C-reactive
protein (CRP) levels as non-specific inflammatory markers with
interpretable clinical values. With strength of data from recent large
nationally representative community sample surveys, the research
approach illustrates value of a quantile regressions approach in lieu of
the commonly used but relatively arbitrary cutpoints for CRP values.
Methods
The
study population encompasses 20–59 year old participants from the
National Health and Nutrition Examination Surveys, 2005–2010 (n = 1115
recently active cannabis smokers and 8041 non-smokers, identified via
confidential Audio Computer Assisted Self-Interviews). Age, sex, race,
education, income–poverty ratio, alcohol consumption, and tobacco
smoking also were measured, together with body mass index (BMI), which
actually might be on a mediational path. Quantile regressions, with
bootstrapping for variance estimation, made it possible to hold these
covariates constant while estimating cannabis-CRP associations.
Results
Evidence suggesting possible cannabis-attributable immunomodulation emerges at CRP levels below the median (p < 0.05).
Whereas BMI might help explain a cannabis link with serum CRP, but
BMI-stratified analyses disclosed no appreciable variation of the
cannabis–CRP relationship across BMI subgroups.
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