http://www.ncbi.nlm.nih.gov/pubmed/25420446
Abstract
Fixed-dose dextromethorphan/quinidine capsules (Nuedexta®)
utilize quinidine to inhibit the metabolism of dextromethorphan,
enabling high plasma dextromethorphan concentrations to be reached
without using a larger dose of the drug. The drug combination is the
first treatment to be approved for pseudobulbar affect (PBA), a
condition of contextually inappropriate/exaggerated emotional expression
that often occurs in adults with neurological damage conditions, such
as amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), stroke,
traumatic brain injury, Alzheimer's disease or Parkinson's disease.
Dextromethorphan/quinidine at the recommended dosages of 20/10 or
30/10 mg twice daily reduced the rate of PBA episodes and improved PBA
severity in a 12-week, double-blind, placebo-controlled trial in adults
with ALS or MS (STAR), with further improvements in the severity of the
condition observed in a 12-week open-label extension phase.
Dextromethorphan/quinidine 20/10 mg twice daily also improved PBA
secondary to dementia in a cohort of a 12-week noncomparative trial
(PRISM II). The drug combination was generally well tolerated in these
studies, with no particular safety or tolerability concerns. Although
longer-term efficacy and tolerability data for
dextromethorphan/quinidine 20/10 or 30/10 mg twice daily would be
beneficial, current evidence indicates that it is a useful option in the
treatment of adults with PBA.
Well I just wanted to add that in an anoxic brain injury(whole brain stroke if we`re not getting technical) regular OTC DM had the best effect I`ve seen since ambien worked backwards and woke him up and freed up his movements. Sadly the DM wow effect has dwindled too, but was so good to see. I`ve been reading all kinds of stuff on it since and yes it all started with an article for neudexta in a magazine called quest. It had the study and how some ALS patients reported better speech and swallowing. A few other anoxic peps have tried it and had some results too. All so interesting and I`m hooked on finding out why. Wish I was a lot smarter though reading all the technical stuff :) Ruth
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