Does oral Coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in Chronic Fatigue Syndrome?

Is CFS close enough to stroke fatigue to possibly be able to use the same interventions? Tell your doctor to find out. Do not self-prescribe.
http://online.liebertpub.com/doi/abs/10.1089/ars.2014.6181

Dr. JESUS CASTRO-MARRERO, Ph.D.

Vall de Hebron Univ Hospital Research Institute, CFS Research Unit,

PASSEIG DE VALL DE HEBRON, 119-129

,

PASSEIG DE VALL DE HEBRON, 119-129

, BARCELONA, Barcelona, Spain,

08035

, 934893000 (EXT. 4927), 932746708; jesus.castro@vhir.org

Prof. Mario D. Cordero

Research Laboratory, Dental School, Universidad de Sevilla, Sevilla, Spain,

C/Avicena s/n

, Sevilla, Spain,

41009

, +34 954 481120, +34 954 486784; mdcormor@us.es

Dr. Maria Jose jesus.castro@vhir.org Segundo

Vitae Natural Nutrition, SL, Research and Development (R&D), BARCELONA, Sant Cugat del Vallès, Spain; msegundo@vitae.es

Naia Saez-Francas

Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Departamento de Psiquiatría y Medicina Legal, BARCELONA, BARCELONA, Spain; nasaez2@gmail.com

Dr. Natalia Calvo

Vall d'Hebron University Hospital, Departamento de Psiquiatría y Medicina Legal, BARCELONA, BARCELONA, Spain; nacalvo@vhebron.net

Dr. Lourdes Román-Malo

Dental School University of Sevilla, Research Laboratory, SEVILLA, SEVILLA, Spain; lvrmalo@gmail.com

Luisa Aliste

Vall d'Hebron University Hospital, CFS Clinical Unit, BARCELONA, BARCELONA, Spain; luisa_a_s@yahoo.es

Prof. Tomas Fernandez de Sevilla

Vall d'Hebron University Hospital, CFS Clinical Unit, BARCELONA, BARCELONA, Spain; 10653tfd@comb.cat

Dr. Jose Alegre-Martin

Vall d'Hebron University Hospital, CFS Clinical Unit, BARCELONA, BARCELONA, Spain; jalegre@vhebron.net

Accepted: November 03 2014
Received: November 03 2014

ABSTRACT

Chronic Fatigue Syndrome (CFS) is a chronic and extremely debilitating illness characterized by prolonged fatigue and multiple symptoms with unknown cause, diagnostic test, or universally effective treatment. Inflammation, oxidative stress, mitochondrial dysfunction, and CoQ10 deficiency have been well documented in CFS. We conducted an 8-weeks randomized, double-blind, placebo-controlled trial to evaluate the benefits of oral CoQ10 (200 mg/day) plus NADH (20 mg/day) supplementation on fatigue and biochemical parameters in 73 Spanish CFS patients. This study was registered in ClinicalTrials.gov (NCT02063126). A significant improvement of fatigue showing a reduction in FIS total score (p< 0.05) was reported in treated group vs. placebo. In addition, a recovery of the biochemical parameters was also reported. NAD+/NADH (p< 0.001), CoQ10 (p< 0.05), ATP (p< 0.05) and citrate synthase (p< 0.05) were significantly higher and lipoperoxides (p< 0.05) were significantly lower in blood mononuclear cells (BMCs) of the treated group. These observations lead to the hypothesis that the oral CoQ10 plus NADH supplementation could confers potential therapeutic benefits on fatigue and biochemical parameters in CFS. Larger sample trials are warranted to confirm these findings.