NeuroGrid: recording action potentials from the surface of the brain

And with this our doctors could determine what problems exist and match stroke protocols to correct those problems.
http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.3905.html

• Dion Khodagholy,
• Jennifer N Gelinas,
• Thomas Thesen,
• Werner Doyle,
• Orrin Devinsky,
• George G Malliaras
• & György Buzsáki

• Affiliations
• Contributions
• Corresponding author

Nature Neuroscience

(2014)

doi:10.1038/nn.3905

Received

14 July 2014

Accepted

21 November 2014

Published online

22 December 2014

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Abstract

Recording from neural networks at the resolution of action potentials is critical for understanding how information is processed in the brain. Here, we address this challenge by developing an organic material–based, ultraconformable, biocompatible and scalable neural interface array (the ‘NeuroGrid’) that can record both local field potentials(LFPs) and action potentials from superficial cortical neurons without penetrating the brain surface. Spikes with features of interneurons and pyramidal cells were simultaneously acquired by multiple neighboring electrodes of the NeuroGrid, allowing for the isolation of putative single neurons in rats. Spiking activity demonstrated consistent phase modulation by ongoing brain oscillations and was stable in recordings exceeding 1 week's duration. We also recorded LFP-modulated spiking activity intraoperatively in patients undergoing epilepsy surgery. The NeuroGrid constitutes an effective method for large-scale, stable recording of neuronal spikes in concert with local population synaptic activity, enhancing comprehension of neural processes across spatiotemporal scales and potentially facilitating diagnosis and therapy for brain disorders.