Cumulative Use of Strong Anticholinergics and Incident Dementia

You probably have to consult with your doctor to make sure you aren't increasing your dementia risk.

Abstract here:

Cumulative Use of Strong Anticholinergics and Incident Dementia

Readable PSYblog here:

4 Very Common Medicines Newly Linked to Irreversible Dementia Risk

Four commonly used drugs which have strong anticholinergic effects are:

1. Doxepin (Sinequan) – an older antidepressant.
2. Chlorpheniramine (Chlor-Trimeton) – an antihistamine used to treat hayfever.
3. Diphenhydramine (Benadryl) – another antihistamine often used to treat hayfever and sometimes used to aid sleep.
4. Oxybutynin (Ditropan) – for bladder control.

The study, which is published in JAMA Internal Medicine, tracked 3,434 people over the age of 65 who had no signs of dementia (Gray et al., 2015).
They were followed up over 7 years, during which time 797 developed dementia.