The Antioxidant Effect of Magnesium and Its Protective Role for Blood-Brain Barrier in Acute Stroke - Model and Clinical

And maybe you should be talking to your doctor to find out how they are applying this to stroke patients. It seems it might be useful; I would want something like this for my next stroke but unless YOU start screaming to your doctor and hospital this won't be available anytime soon. Inaction is pretty much the order of the decade for any stroke intervention.


http://scholar.google.com/scholar_url?url=http://www.researchgate.net/profile/Natallia_Shcharbina/publication/263215418_The_Antioxidant_Effect_of_Magnesium_and_Its_Protective_Role_for_Blood-Brain_Barrier_in_Acute_Stroke_-_Model_and_Clinical_Studies/links/02e7e53a2caab9e9fc000000.pdf&hl=en&sa=X&scisig=AAGBfm0rNYbXz7ThRzFLQIwjY6x6fftqEg&nossl=1&oi=scholaralrt

 

Abstract

Objective: to elucidate the antioxidant effect of intravenous magnesium sulfate in stroke. Background: Magnesium (Mg) is a single clinically approved antagonist of NMDA receptors used in stroke treatment. Methods: Experimental investigation: 36 adult rabbits were studied at modeling of brain ischemia in acute and chronic experiments. The parameters of lipid peroxidation (LPO) processes, the activity of glutathione peroxidase (GPx), the number of erythrocytes were determined in rabbit blood. Clinical study: The parameters of LPO processes, the activity of GPx, the state of blood-brain barrier were studied in 54 patients with acute ischemic stroke. 29 patients with stroke received a standard treatment, while 25 patients -intravenous MgSO4 in addition to standard therapy. Results: Experimental investigation: In acute experiment the treatment of rabbits with Mg led to the normalization of LPO parameters and the activation of GPx in blood after 3 hours of ischemia and 2 hours of reperfusion. The increased activity of GPx in blood of rabbits treated with Mg was also observed in chronic experiment on the fifth day after ischemia. Clinical study: Intravenous Mg in patients with stroke led to normalization of LPO processes and increase of GPx activity in blood on days 12-15 after stroke onset in comparison with patients treated without Mg. Intravenous Mg also decreased two times the number of patients with blood-brain barrier dysfunction. Conclusions: Mg has an antioxidant effect in acute ischemic stroke. It can be used both for primary and for secondary neuroprotection - the correction of oxidative stress and dysfunction of blood- brain barrier in acute stroke.

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