Middle cerebral artery remodeling following transient brain ischemia is linked to early postischemic hyperemia: a target of uric acid treatment

Sounds like a good way to reduce reperfusion damage. What does your doctor think of this? Does your doctor ever think at all? Mine didn't. I don't give a shit that this was in rats your doctor needs to start up a clinical trial. How many clinical trials are in your neurologists goals for the year? If none, you need to fire that neurologist.
http://ajpheart.physiology.org/content/early/2015/01/26/ajpheart.00001.2015

Yara Onetti , Ana P. Dantas , Belén Pérez , Roger Cugota , Angel Chamorro , Anna M Planas , Elisabet Vila , Francesc Jiménez-Altayó

American Journal of Physiology - Heart and Circulatory PhysiologyPublished 30 January 2015Vol. no. , DOI: 10.1152/ajpheart.00001.2015

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Abstract

Ischemia impairs blood supply to the brain and reperfusion is important to restore cerebral blood flow (CBF) and rescue neurons from cell death. However, reperfusion can induce CBF values exceeding the basal values prior to ischemia. This hyperemic effect has been associated with a worse ischemic brain damage, albeit the mechanisms that contribute to infarct expansion are not clear. In this study, we investigated the influence of early postischemic hyperemia on brain damage and middle cerebral artery (MCA) properties, and the effect of treatment with the endogenous antioxidant uric acid (UA). The MCA was occluded for 90 min followed by 24 h reperfusion in adult male Sprague-Dawley rats. Cortical CBF increases at reperfusion beyond 20% of basal values were taken as indicative of hyperemia. UA (16 mg/kg) or vehicle (Locke's buffer) was administered i.v. 135 min after MCA occlusion. Hyperemic compared to non-hyperemic rats showed MCA wall thickening (sham: 22.4 ± 0.8 μm; non-hyperemic: 23.1 ± 1.2 μm; hyperemic: 27.8 ± 0.9 at 60 mmHg; P < 0.001, hyperemic vs. sham) involving adventitial cell proliferation, increased oxidative stress and interleukin-18, and more severe brain damage. Thus, MCA remodeling after ischemia/reperfusion takes place under vascular oxidative and inflammatory stress conditions linked to hyperemia. UA administration attenuated MCA wall thickening, induced passive lumen expansion, and reduced brain damage in hyperemic rats, though it did not increase brain UA concentration. We conclude that hyperemia at reperfusion following brain ischemia induces vascular damage that can be attenuated by administration of the endogenous antioxidant UA.