Saturday, March 14, 2015

Ribosomes regulate stem cell fate

There is still so much unknown about stem cells that current research seems more like a shot in the dark that any logical way to proceed. This is one of the many reasons that the miracle of stem cells contributing instantly to Godie Howes' recovery is impossible to believe.
http://www.sciencemag.org/content/347/6227/1214.4.full?utm_campaign=email-sci-ec&utm_src=email
The use of stem cells in regenerative medicine holds enormous therapeutic potential. However, scientists still need to fully understand the molecular signals that control the ability of stem cells to self-renew and differentiate. To identify genes that many regulate this, Fortier et al. screened a library of mouse embryonic stem cells (ESCs) containing chromosomal deletions. They found that the loss of a single copy of several genes encoding protein subunits of the ribosome, a large protein complex that translates mRNA into proteins, resulted in impaired ESC differentiation but did not affect self-renewal. 

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