Dose-related effects of chronic resveratrol administration on neurogenesis, angiogenesis, and corticosterone secretion are associated with improved spatial memory retention following global cerebral ischemia

You'll have to ask your doctor to figure out the resveratrol dose needed when converting from rat size to human size and then into how many glasses of wine you need each day. Type of wine would be good to know. Cabernet Sauvignon, Chianti, Malbec, Merlot, Nebbiolo, Pinot Noir, Syrah, Tempranillo, Zinfandel?
Don't do this on your own, your doctor has to prescribe the red wine for you. You do want most of it paid for from your insurance, don't you?
http://www.maneyonline.com/doi/abs/10.1179/1476830515Y.0000000020

 

Catrinel Girbovan¹; Pamela Kent¹; Zul Merali^1,2; Hélène Plamondon¹

Author Affilations

Keywords: Resveratrol, Cerebral ischemia, Neurogenesis, Angiogenesis, Spatial memory, Corticosterone, Restraint stress

DOI: http://dx.doi.org/10.1179/1476830515Y.0000000020

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Abstract

Objectives

The polyphenol resveratrol has shown regulatory effects on hippocampal neurogenesis, which according to the neurovascular niche hypothesis, likely to involve stimulation of angiogenesis. In rodents, global cerebral ischemia leads to selective CA1 neuronal damage, spatial memory impairments, lasting changes in corticosterone (CORT) secretion, and increased neurogenesis. This study examined dose-related effects of 21-day RSV treatment on markers associated with neurogenesis (DCX, PSA-NCAM) and angiogenesis (CD31) in the hippocampus at short (7-day) and long-term (85-day) intervals following global ischemia. In parallel, post-ischemic and stress-induced CORT levels and spatial memory in the Morris water maze were determined.

Methods

Five groups of male Wistar rats were included: sham/saline, ischemia/saline, ischemia/1 mg/kg RSV, ischemia/10 mg/kg RSV, and sham/10 mg/kg RSV. Changes in expression of plasticity markers were paralleled by assessment of basal- and stress-induced CORT secretions, and spatial memory performance.

Results

Our findings revealed a significant attenuation of ischemia-induced DCX/PSA-NCAM expression in RSV-treated rats, whereas RSV treatment increased angiogenesis in the injured CA1 region. RSV attenuated CORT levels 3 days post-ischemia and a trend toward attenuating CORT secretion in response to 15 minutes restraint stress. Increased swimming latencies in the target quadrant during the MWM probe trial in RSV-treated ischemic rats support beneficial effects of on spatial memory retention.

Discussion

Our findings uncover time- and dose-related effects of RSV and global ischemia on the regulation of hippocampal plasticity. Changes in neuro- and angiogenesis are consistent with RSV neuroprotective effects, but appear independent of RSV regulatory effects on corticosterone secretion.