Saturday, May 30, 2015

Coordinating neurons with blood vessels

We need this for both neurogenesis and stem cells. What is your doctor doing to follow up on this line of therapy? It may not help us in time but future survivors will need this.
http://www.sciencemag.org/content/348/6238/986.1.full?
Science
Vol. 348 no. 6238 p. 986
DOI: 10.1126/science.348.6238.986-a                        


Figure
Neurons and blood vessels in the retina
PHOTO: THOMAS DEERINCK/NCMIR/SCIENCE SOURCE

The retina develops as interleaved layers of neurons and blood vessels. Usui et al. show that in mice, the development of blood vessel layers depends on signals from amacrine cells, a type of interneuron in the retina. Too much or too little signal resulted in too many or too few blood vessels, particularly affecting the intermediate vascular plexus (a network of blood vessels) embedded within the retina. This cellular crosstalk coordinates neuronal demand for oxygen with the blood's ability to supply it. With the intermediate vascular plexus poorly formed, photoreceptors (a type of neuron) degenerate, leading to deficits in vision.
J. Clin. Invest. 10.1172/JCI80297 (2015).                                    

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